Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention 09 AM Call for Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krishnamachary, B.
Right arrow Articles by Semenza, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krishnamachary, B.
Right arrow Articles by Semenza, G. L.
[Cancer Research 63, 1138-1143, March 1, 2003]
© 2003 American Association for Cancer Research

Tumor Biology

Regulation of Colon Carcinoma Cell Invasion by Hypoxia-Inducible Factor 11

Balaji Krishnamachary, Shannon Berg-Dixon, Brian Kelly, Faton Agani, David Feldser, Gloria Ferreira, Narayan Iyer, Jessica LaRusch, Brian Pak, Panthea Taghavi and Gregg L. Semenza2

McKusick-Nathans Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914

Hypoxia-inducible factor 1 (HIF-1) transactivates genes the products of which mediate tumor angiogenesis and glycolytic metabolism. Overexpression of the HIF-1{alpha} subunit, resulting from intratumoral hypoxia and genetic alterations, has been demonstrated in common human cancers and is correlated with tumor angiogenesis and patient mortality. Here we demonstrate that hypoxia or HIF-1{alpha} overexpression stimulates Matrigel invasion by HCT116 human colon carcinoma cells, whereas this process is inhibited by a small interfering RNA directed against HIF-1{alpha}. We show that HIF-1 regulates the expression of genes encoding cathepsin D; matrix metalloproteinase 2; urokinase plasminogen activator receptor (uPAR); fibronectin 1; keratins 14, 18, and 19; vimentin; transforming growth factor {alpha}; and autocrine motility factor, which are proteins that play established roles in the pathophysiology of invasion. Neutralizing antibodies against uPAR block tumor cell invasion induced by hypoxia or HIF-1{alpha} overexpression. These results provide a molecular basis for promotion of the invasive cancer phenotype by hypoxia and/or HIF-1{alpha} overexpression.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
R. A. Whipple, E. M. Balzer, E. H. Cho, M. A. Matrone, J. R. Yoon, and S. S. Martin
Vimentin Filaments Support Extension of Tubulin-Based Microtentacles in Detached Breast Tumor Cells
Cancer Res., July 15, 2008; 68(14): 5678 - 5688.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-T. Lin, I-H. Kuo, C.-C. Chang, C.-Y. Chu, H.-Y. Chen, B.-R. Lin, M. Sureshbabu, H.-J. Shih, and M.-L. Kuo
Involvement of Hypoxia-inducing Factor-1{alpha}-dependent Plasminogen Activator Inhibitor-1 Up-regulation in Cyr61/CCN1-induced Gastric Cancer Cell Invasion
J. Biol. Chem., June 6, 2008; 283(23): 15807 - 15815.
[Abstract] [Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
G. L. Semenza
Hypoxia-inducible Factor 1 and Human Cancer
ASCO Educational Book, January 1, 2008; 2008(1): 548 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. A. Lang, C. Moser, A. Gaumann, D. Klein, G. Glockzin, F. C. Popp, M. H. Dahlke, P. Piso, H. J. Schlitt, E. K. Geissler, et al.
Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1{alpha} Autocrine Loop, and Reduces Orthotopic Tumor Growth
Clin. Cancer Res., November 1, 2007; 13(21): 6459 - 6468.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. Egger, W. Schgoer, A. G. E. Beer, J. Jeschke, J. Leierer, M. Theurl, S. Frauscher, O. M. Tepper, A. Niederwanger, A. Ritsch, et al.
Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1{alpha}- and basic FGF-dependent pathway in muscle cells
FASEB J, September 1, 2007; 21(11): 2906 - 2917.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang and R. P. Hill
Hypoxia Enhances Metastatic Efficiency in HT1080 Fibrosarcoma Cells by Increasing Cell Survival in Lungs, Not Cell Adhesion and Invasion
Cancer Res., August 15, 2007; 67(16): 7789 - 7797.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Q. Zhang, X. Tang, Z.-F. Zhang, R. Velikina, S. Shi, and A. D. Le
Nicotine Induces Hypoxia-Inducible Factor-1{alpha} Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor Mediated Signaling Pathways
Clin. Cancer Res., August 15, 2007; 13(16): 4686 - 4694.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Merighi, A. Benini, P. Mirandola, S. Gessi, K. Varani, C. Simioni, E. Leung, S. Maclennan, P. G. Baraldi, and P. A. Borea
Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1{alpha}, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells
Mol. Pharmacol., August 1, 2007; 72(2): 395 - 406.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
R. D. Lester, M. Jo, V. Montel, S. Takimoto, and S. L. Gonias
uPAR induces epithelial mesenchymal transition in hypoxic breast cancer cells
J. Cell Biol., July 24, 2007; 178(3): 425 - 436.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
X. Tang, Q. Zhang, J. Nishitani, J. Brown, S. Shi, and A. D. Le
Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1{alpha} Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells
Clin. Cancer Res., May 1, 2007; 13(9): 2568 - 2576.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
R. A. Cardone, A. Bellizzi, G. Busco, E. J. Weinman, M. E. Dell'Aquila, V. Casavola, A. Azzariti, A. Mangia, A. Paradiso, and S. J. Reshkin
The NHERF1 PDZ2 Domain Regulates PKA-RhoA-p38-mediated NHE1 Activation and Invasion in Breast Tumor Cells
Mol. Biol. Cell, May 1, 2007; 18(5): 1768 - 1780.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Spinella, L. Rosano, V. Di Castro, S. Decandia, M. R. Nicotra, P. G. Natali, and A. Bagnato
Endothelin-1 and Endothelin-3 Promote Invasive Behavior via Hypoxia-Inducible Factor-1{alpha} in Human Melanoma Cells
Cancer Res., February 15, 2007; 67(4): 1725 - 1734.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Liao, C. Corle, T. N. Seagroves, and R. S. Johnson
Hypoxia-Inducible Factor-1{alpha} Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression
Cancer Res., January 15, 2007; 67(2): 563 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Q. Ke and M. Costa
Hypoxia-Inducible Factor-1 (HIF-1)
Mol. Pharmacol., November 1, 2006; 70(5): 1469 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Heidemann, D G Binion, W Domschke, and T Kucharzik
Antiangiogenic therapy in human gastrointestinal malignancies.
Gut, October 1, 2006; 55(10): 1497 - 1511.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Oda, K. Hirota, K. Nishi, S. Takabuchi, S. Oda, H. Yamada, T. Arai, K. Fukuda, T. Kita, T. Adachi, et al.
Activation of hypoxia-inducible factor 1 during macrophage differentiation
Am J Physiol Cell Physiol, July 1, 2006; 291(1): C104 - C113.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. A. Carroll and M. Ashcroft
Role of Hypoxia-Inducible Factor (HIF)-1{alpha} versus HIF-2{alpha} in the Regulation of HIF Target Genes in Response to Hypoxia, Insulin-Like Growth Factor-I, or Loss of von Hippel-Lindau Function: Implications for Targeting the HIF Pathway.
Cancer Res., June 15, 2006; 66(12): 6264 - 6270.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. D. Unwin, D. L. Smith, D. Blinco, C. L. Wilson, C. J. Miller, C. A. Evans, E. Jaworska, S. A. Baldwin, K. Barnes, A. Pierce, et al.
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells
Blood, June 15, 2006; 107(12): 4687 - 4694.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
X. Bi, Q. Lin, T. W. Foo, S. Joshi, T. You, H.-M. Shen, C. N. Ong, P. Y. Cheah, K. W. Eu, and C.-L. Hew
Proteomic Analysis of Colorectal Cancer Reveals Alterations in Metabolic Pathways: Mechanism of Tumorigenesis
Mol. Cell. Proteomics, June 1, 2006; 5(6): 1119 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Q. Zhang, X. Tang, Q. Lu, Z. Zhang, J. Rao, and A. D. Le
Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1{alpha} protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells
Mol. Cancer Ther., May 1, 2006; 5(5): 1227 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. G. Heerdt, M. A. Houston, and L. H. Augenlicht
Growth Properties of Colonic Tumor Cells Are a Function of the Intrinsic Mitochondrial Membrane Potential
Cancer Res., February 1, 2006; 66(3): 1591 - 1596.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. T. Dang, F. Chen, L. B. Gardner, J. M. Cummins, C. Rago, F. Bunz, S. V. Kantsevoy, and L. H. Dang
Hypoxia-Inducible Factor-1{alpha} Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts
Cancer Res., February 1, 2006; 66(3): 1684 - 1693.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. O. D. Critchley, J. Osei, T. A. Henderson, L. Boswell, K. J. Sales, H. N. Jabbour, and N. Hirani
Hypoxia-Inducible Factor-1{alpha} Expression in Human Endometrium and Its Regulation by Prostaglandin E-Series Prostanoid Receptor 2 (EP2)
Endocrinology, February 1, 2006; 147(2): 744 - 753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Ben-Yosef, A. Miller, S. Shapiro, and N. Lahat
Hypoxia of endothelial cells leads to MMP-2-dependent survival and death
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1321 - C1331.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Q. Zhang, X. Tang, Q. Y. Lu, Z. F. Zhang, J. Brown, and A. D. Le
Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1{alpha} and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
Mol. Cancer Ther., October 1, 2005; 4(10): 1465 - 1474.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
T. Funasaka, T. Yanagawa, V. Hogan, and A. Raz
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
FASEB J, September 1, 2005; 19(11): 1422 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
E. W. Newcomb, M. A. Ali, T. Schnee, L. Lan, Y. Lukyanov, M. Fowkes, D. C. Miller, and D. Zagzag
Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1{alpha} expression in human glioma cells by a proteasome-independent pathway: Implications for in vivo therapy
Neuro-oncol, July 1, 2005; 7(3): 225 - 235.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Phillips, J. Mestas, M. Gharaee-Kermani, M. D. Burdick, A. Sica, J. A. Belperio, M. P. Keane, and R. M. Strieter
Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1{alpha}
J. Biol. Chem., June 10, 2005; 280(23): 22473 - 22481.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Frede, P. Freitag, T. Otto, C. Heilmaier, and J. Fandrey
The Proinflammatory Cytokine Interleukin 1{beta} and Hypoxia Cooperatively Induce the Expression of Adrenomedullin in Ovarian Carcinoma Cells through Hypoxia Inducible Factor 1 Activation
Cancer Res., June 1, 2005; 65(11): 4690 - 4697.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
R. Korn, S. Rohrig, S. Schulze-Kremer, and U. Brinkmann
Common denominator procedure: a novel approach to gene-expression data mining for identification of phenotype-specific genes
Bioinformatics, June 1, 2005; 21(11): 2766 - 2772.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
B. Kaur, F. W. Khwaja, E. A. Severson, S. L. Matheny, D. J. Brat, and E. G. Van Meir
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
Neuro-oncol, April 1, 2005; 7(2): 134 - 153.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
S.-O. Yoon, S. Shin, and A. M. Mercurio
Hypoxia Stimulates Carcinoma Invasion by Stabilizing Microtubules and Promoting the Rab11 Trafficking of the {alpha}6{beta}4 Integrin
Cancer Res., April 1, 2005; 65(7): 2761 - 2769.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Nitori, Y. Ino, Y. Nakanishi, T. Yamada, K. Honda, K. Yanagihara, T. Kosuge, Y. Kanai, M. Kitajima, and S. Hirohashi
Prognostic Significance of Tissue Factor in Pancreatic Ductal Adenocarcinoma
Clin. Cancer Res., April 1, 2005; 11(7): 2531 - 2539.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Nakanishi, S. Hiroi, S. Tominaga, S. Aida, H. Kasamatsu, S. Matsuyama, T. Matsuyama, and T. Kawai
Expression of Hypoxia-Inducible Factor-1{alpha} Protein Predicts Survival in Patients with Transitional Cell Carcinoma of the Upper Urinary Tract
Clin. Cancer Res., April 1, 2005; 11(7): 2583 - 2590.
[Abstract] [Full Text] [PDF]

Home page
 aacrmtgHome page
G. L. Semenza
Involvement of hypoxia-inductible factor 1 in preinvasive and early-stage cancer
AACR Meeting Abstracts, April 1, 2005; 2005(1): 1459 - 1460.
[Abstract]

Home page
 Cancer Res.Home page
G. Cronwright, K. Le Blanc, C. Gotherstrom, P. Darcy, M. Ehnman, and B. Brodin
Cancer/Testis Antigen Expression in Human Mesenchymal Stem Cells: Down-regulation of SSX Impairs Cell Migration and Matrix Metalloproteinase 2 Expression
Cancer Res., March 15, 2005; 65(6): 2207 - 2215.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-P. Piret, E. Minet, J.-P. Cosse, N. Ninane, C. Debacq, M. Raes, and C. Michiels
Hypoxia-inducible Factor-1-dependent Overexpression of Myeloid Cell Factor-1 Protects Hypoxic Cells against tert-Butyl Hydroperoxide-induced Apoptosis
J. Biol. Chem., March 11, 2005; 280(10): 9336 - 9344.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E. Hervouet, J. Demont, P. Pecina, A. Vojtiskova, J. Houstek, H. Simonnet, and C. Godinot
A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis
Carcinogenesis, March 1, 2005; 26(3): 531 - 539.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. McMahon, F. Grondin, P. P. McDonald, D. E. Richard, and C. M. Dubois
Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1: IMPACT ON THE BIOACTIVATION OF PROPROTEINS
J. Biol. Chem., February 25, 2005; 280(8): 6561 - 6569.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. L. Ricker, Z. Chen, X. P. Yang, V. S. Pribluda, G. M. Swartz, and C. Van Waes
2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1{alpha}, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., December 15, 2004; 10(24): 8665 - 8673.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty
Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy
Integr Cancer Ther, December 1, 2004; 3(4): 349 - 380.
[Abstract] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Tsutsumi, T. Yanagawa, T. Shimura, H. Kuwano, and A. Raz
Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis
Clin. Cancer Res., November 15, 2004; 10(22): 7775 - 7784.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
P. Vaupel
The Role of Hypoxia-Induced Factors in Tumor Progression
Oncologist, November 1, 2004; 9(suppl_5): 10 - 17.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Robertson, C. Potter, and A. L. Harris
Role of Carbonic Anhydrase IX in Human Tumor Cell Growth, Survival, and Invasion
Cancer Res., September 1, 2004; 64(17): 6160 - 6165.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Lin, S.-C. Tsai, C.-C. Lee, B.-W. Wang, J.-Y. Liou, and K.-G. Shyu
Berberine Inhibits HIF-1{alpha} Expression via Enhanced Proteolysis
Mol. Pharmacol., September 1, 2004; 66(3): 612 - 619.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
T. Acker and H. Acker
Cellular oxygen sensing need in CNS function: physiological and pathological implications
J. Exp. Biol., August 15, 2004; 207(18): 3171 - 3188.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Giatromanolaki, M. I. Koukourakis, H. M. Sowter, E. Sivridis, S. Gibson, K. C. Gatter, and A. L. Harris
BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non-Small Cell Lung Cancer
Clin. Cancer Res., August 15, 2004; 10(16): 5566 - 5571.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Okami, D. M. Simeone, and C. D. Logsdon
Silencing of the Hypoxia-Inducible Cell Death Protein BNIP3 in Pancreatic Cancer
Cancer Res., August 1, 2004; 64(15): 5338 - 5346.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
O. Stoeltzing, M. F. McCarty, J. S. Wey, F. Fan, W. Liu, A. Belcheva, C. D. Bucana, G. L. Semenza, and L. M. Ellis
Role of Hypoxia-Inducible Factor 1{alpha} in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation
J Natl Cancer Inst, June 16, 2004; 96(12): 946 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Wakisaka, S. Kondo, T. Yoshizaki, S. Murono, M. Furukawa, and J. S. Pagano
Epstein-Barr Virus Latent Membrane Protein 1 Induces Synthesis of Hypoxia-Inducible Factor 1{alpha}
Mol. Cell. Biol., June 15, 2004; 24(12): 5223 - 5234.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. R. Laderoute, J. M. Calaoagan, M. Knapp, and R. S. Johnson
Glucose Utilization Is Essential for Hypoxia-Inducible Factor 1{alpha}-Dependent Phosphorylation of c-Jun
Mol. Cell. Biol., May 15, 2004; 24(10): 4128 - 4137.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Zelzer, R. Mamluk, N. Ferrara, R. S. Johnson, E. Schipani, and B. R. Olsen
VEGFA is necessary for chondrocyte survival during bone development
Development, May 1, 2004; 131(9): 2161 - 2171.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Hopfl, O. Ogunshola, and M. Gassmann
HIFs and tumors--causes and consequences
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R608 - R623.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Mizukami, J. Li, X. Zhang, M. A. Zimmer, O. Iliopoulos, and D. C. Chung
Hypoxia-Inducible Factor-1-Independent Regulation of Vascular Endothelial Growth Factor by Hypoxia in Colon Cancer
Cancer Res., March 1, 2004; 64(5): 1765 - 1772.
[Abstract] [Full Text] [PDF]

Home page
 aacrmtgHome page
G. L. Semenza
Overexpression of hypoxia-inducible factor 1 in human cancers: Mechanisms and consequences.
AACR Meeting Abstracts, March 1, 2004; 2004(1): 1312 - 1313.
[Abstract]

Home page
 Cancer Res.Home page
A. Rapisarda, B. Uranchimeg, O. Sordet, Y. Pommier, R. H. Shoemaker, and G. Melillo
Topoisomerase I-Mediated Inhibition of Hypoxia-Inducible Factor 1: Mechanism and Therapeutic Implications
Cancer Res., February 15, 2004; 64(4): 1475 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. J. Brat, A. A. Castellano-Sanchez, S. B. Hunter, M. Pecot, C. Cohen, E. H. Hammond, S. N. Devi, B. Kaur, and E. G. Van Meir
Pseudopalisades in Glioblastoma Are Hypoxic, Express Extracellular Matrix Proteases, and Are Formed by an Actively Migrating Cell Population
Cancer Res., February 1, 2004; 64(3): 920 - 927.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Lastraioli, L. Guasti, O. Crociani, S. Polvani, G. Hofmann, H. Witchel, L. Bencini, M. Calistri, L. Messerini, M. Scatizzi, et al.
herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor Cells
Cancer Res., January 15, 2004; 64(2): 606 - 611.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. S Cherniack
Oxygen sensing: applications in humans
J Appl Physiol, January 1, 2004; 96(1): 352 - 358.
[Abstract] [Full Text] [PDF]

Home page