Cancer Research Cancer Research Funding Available Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Qin, C.
Right arrow Articles by Safe, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Qin, C.
Right arrow Articles by Safe, S.
[Cancer Research 63, 958-964, March 1, 2003]
© 2003 American Association for Cancer Research

Endocrinology

Peroxisome Proliferator-activated Receptor {gamma} Agonists Induce Proteasome-dependent Degradation of Cyclin D1 and Estrogen Receptor {alpha} in MCF-7 Breast Cancer Cells1

Chunhua Qin, Robert Burghardt, Roger Smith, Mark Wormke, Jessica Stewart and Stephen Safe2

Departments of Veterinary Physiology and Pharmacology [C. Q., M. W., J. S., S. S.], Veterinary Anatomy and Public Health [R. B.], and Veterinary Pathobiology [R. S.], Texas A&M University, College Station, Texas, and Institute of Biosciences and Technology, The Texas A&M University System Health Science Center, Houston, Texas 77843-4466 [S. S.]

Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) {gamma} agonists ciglitazone or 15-deoxy-{Delta}12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) {alpha} proteins, and this was accompanied by decreased cell proliferation and G1-G0->S-phase progression. Down-regulation of cyclin D1 and ER{alpha} by PPAR{gamma} agonists was inhibited in cells cotreated with the proteasome inhibitors MG132 and PSII, but not in cells cotreated with the protease inhibitors calpain II and calpeptin. Moreover, after treatment of MCF-7 cells with 15-deoxy-{Delta}12,14-prostaglandin J2 and immunoprecipitation with cyclin D1 or ER{alpha} antibodies, there was enhanced formation of ubiquitinated cyclin D1 and ER{alpha} bands. Thus, PPAR{gamma}-induced inhibition of breast cancer cell growth is due, in part, to proteasome-dependent degradation of cyclin D1 (and ER{alpha}), and this pathway may be important for other cancer cell lines.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
Y. Yin, H. Yuan, X. Zeng, L. Kopelovich, and R. I. Glazer
Inhibition of Peroxisome Proliferator-Activated Receptor {gamma} Increases Estrogen Receptor-Dependent Tumor Specification
Cancer Res., January 15, 2009; 69(2): 687 - 694.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wei, H.-C. Yang, H.-C. Chuang, J. Yang, S. K. Kulp, P.-J. Lu, M.-D. Lai, and C.-S. Chen
A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells
J. Biol. Chem., September 26, 2008; 283(39): 26759 - 26770.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. U. Mertens-Talcott, S. Chintharlapalli, X. Li, and S. Safe
The Oncogenic microRNA-27a Targets Genes That Regulate Specificity Protein Transcription Factors and the G2-M Checkpoint in MDA-MB-231 Breast Cancer Cells
Cancer Res., November 15, 2007; 67(22): 11001 - 11011.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. York, M. Abdelrahim, S. Chintharlapalli, S. D. Lucero, and S. Safe
1,1-Bis(3'-Indolyl)-1-(p-Substitutedphenyl)methanes Induce Apoptosis and Inhibit Renal Cell Carcinoma Growth
Clin. Cancer Res., November 15, 2007; 13(22): 6743 - 6752.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Wei, L.-F. Lin, C.-C. Yang, Y.-C. Wang, G.-D. Chang, H. Chen, and C.-S. Chen
Thiazolidinediones Modulate the Expression of beta-Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of Skp1-Cul1-F-box Protein E3 Ubiquitin Ligase Independently of Peroxisome Proliferator-Activated Receptor {gamma}
Mol. Pharmacol., September 1, 2007; 72(3): 725 - 733.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
F.-S. Chou, P.-S. Wang, S. Kulp, and J. J. Pinzone
Effects of Thiazolidinediones on Differentiation, Proliferation, and Apoptosis
Mol. Cancer Res., June 1, 2007; 5(6): 523 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H.-J. Kim, J.-Y. Kim, Z. Meng, L. H. Wang, F. Liu, T. P. Conrads, T. R. Burke, T. D. Veenstra, and W. L. Farrar
15-Deoxy-{Delta}12,14-Prostaglandin J2 Inhibits Transcriptional Activity of Estrogen Receptor-{alpha} via Covalent Modification of DNA-Binding Domain
Cancer Res., March 15, 2007; 67(6): 2595 - 2602.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Chintharlapalli, S. Papineni, and S. Safe
1,1-Bis(3'-Indolyl)-1-(p-substitutedphenyl)methanes Inhibit Growth, Induce Apoptosis, and Decrease the Androgen Receptor in LNCaP Prostate Cancer Cells through Peroxisome Proliferator-Activated Receptor {gamma}-Independent Pathways
Mol. Pharmacol., February 1, 2007; 71(2): 558 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Ciucci, P. Gianferretti, R. Piva, T. Guyot, T. J. Snape, S. M. Roberts, and M. G. Santoro
Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the I{kappa}B Kinase/Nuclear Factor-{kappa}B Pathway
Mol. Pharmacol., November 1, 2006; 70(5): 1812 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Aiello, G. Pandini, F. Frasca, E. Conte, A. Murabito, A. Sacco, M. Genua, R. Vigneri, and A. Belfiore
Peroxisomal Proliferator-Activated Receptor-{gamma} Agonists Induce Partial Reversion of Epithelial-Mesenchymal Transition in Anaplastic Thyroid Cancer Cells
Endocrinology, September 1, 2006; 147(9): 4463 - 4475.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. Lei, M. Abdelrahim, and S. Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways.
Mol. Cancer Ther., September 1, 2006; 5(9): 2324 - 2336.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. Tosca, P. Solnais, P. Ferre, F. Foufelle, and J. Dupont
Metformin-Induced Stimulation of Adenosine 5' Monophosphate-Activated Protein Kinase (PRKA) Impairs Progesterone Secretion in Rat Granulosa Cells
Biol Reprod, September 1, 2006; 75(3): 342 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
J-R Weng, C-Y Chen, J J Pinzone, M D Ringel, and C-S Chen
Beyond peroxisome proliferator-activated receptor {gamma} signaling: the multi-facets of the antitumor effect of thiazolidinediones.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 401 - 413.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Chintharlapalli, S. Papineni, and S. Safe
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPAR{gamma}-dependent and PPAR{gamma}-independent pathways
Mol. Cancer Ther., May 1, 2006; 5(5): 1362 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Katzenellenbogen, O. Pappo, H. Barash, N. Klopstock, L. Mizrahi, D. Olam, J. Jacob-Hirsch, N. Amariglio, G. Rechavi, L. A. Mitchell, et al.
Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the mdr2-knockout mice.
Cancer Res., April 15, 2006; 66(8): 4001 - 4010.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. M. Banwell, D. P. MacCartney, M. Guy, A. E. Miles, M. R. Uskokovic, J. Mansi, P. M. Stewart, L. P. O'Neill, B. M. Turner, K. W. Colston, et al.
Altered nuclear receptor corepressor expression attenuates vitamin d receptor signaling in breast cancer cells.
Clin. Cancer Res., April 1, 2006; 12(7): 2004 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
T Suzuki, S Hayashi, Y Miki, Y Nakamura, T Moriya, A Sugawara, T Ishida, N Ohuchi, and H Sasano
Peroxisome proliferator-activated receptor {gamma} in human breast carcinoma: a modulator of estrogenic actions.
Endocr. Relat. Cancer, March 1, 2006; 13(1): 233 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Konopleva, W. Zhang, Y.-X. Shi, T. McQueen, T. Tsao, M. Abdelrahim, M. F. Munsell, M. Johansen, D. Yu, T. Madden, et al.
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.
Mol. Cancer Ther., February 1, 2006; 5(2): 317 - 328.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Kassouf, S. Chintharlapalli, M. Abdelrahim, G. Nelkin, S. Safe, and A. M. Kamat
Inhibition of Bladder Tumor Growth by 1,1-Bis(3'-Indolyl)-1-(p-Substitutedphenyl)Methanes: A New Class of Peroxisome Proliferator-Activated Receptor {gamma} Agonists
Cancer Res., January 1, 2006; 66(1): 412 - 418.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Chintharlapalli, S. Papineni, S. J. Baek, S. Liu, and S. Safe
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes Are Peroxisome Proliferator-Activated Receptor {gamma} Agonists but Decrease HCT-116 Colon Cancer Cell Survival through Receptor-Independent Activation of Early Growth Response-1 and Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1
Mol. Pharmacol., December 1, 2005; 68(6): 1782 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C.J. Loy, S. Evelyn, F.K. Lim, M.H. Liu, and E.L. Yong
Growth dynamics of human leiomyoma cells and inhibitory effects of the peroxisome proliferator-activated receptor-{gamma} ligand, pioglitazone
Mol. Hum. Reprod., August 1, 2005; 11(8): 561 - 566.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Chintharlapalli, S. Papineni, M. Konopleva, M. Andreef, I. Samudio, and S. Safe
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Activated Receptor {gamma}-Dependent and -Independent Pathways
Mol. Pharmacol., July 1, 2005; 68(1): 119 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J.-W. Huang, C.-W. Shiau, Y.-T. Yang, S. K. Kulp, K.-F. Chen, R. W. Brueggemeier, C. L. Shapiro, and C.-S. Chen
Peroxisome Proliferator-Activated Receptor {gamma}-Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells
Mol. Pharmacol., April 1, 2005; 67(4): 1342 - 1348.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Fu, C. Wang, Z. Li, T. Sakamaki, and R. G. Pestell
Minireview: Cyclin D1: Normal and Abnormal Functions
Endocrinology, December 1, 2004; 145(12): 5439 - 5447.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Hong, I. Samudio, S. Liu, M. Abdelrahim, and S. Safe
Peroxisome Proliferator-Activated Receptor {gamma}-Dependent Activation of p21 in Panc-28 Pancreatic Cancer Cells Involves Sp1 and Sp4 Proteins
Endocrinology, December 1, 2004; 145(12): 5774 - 5785.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Zhang, M. C. Rodriguez-Galan, J. J. Subleski, J. R. Ortaldo, D. L. Hodge, J.-M. Wang, O. Shimozato, D. A. Reynolds, and H. A. Young
Peroxisome proliferator-activated receptor-{gamma} and its ligands attenuate biologic functions of human natural killer cells
Blood, November 15, 2004; 104(10): 3276 - 3284.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Chintharlapalli, R. Smith III, I. Samudio, W. Zhang, and S. Safe
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes Induce Peroxisome Proliferator-Activated Receptor {gamma}-Mediated Growth Inhibition, Transactivation, and Differentiation Markers in Colon Cancer Cells
Cancer Res., September 1, 2004; 64(17): 5994 - 6001.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. J. Schlezinger, G. J. Howard, C. H. Hurst, J. K. Emberley, D. J. Waxman, T. Webster, and D. H. Sherr
Environmental and Endogenous Peroxisome Proliferator-Activated Receptor {gamma} Agonists Induce Bone Marrow B Cell Growth Arrest and Apoptosis: Interactions between Mono(2-ethylhexyl)phthalate, 9-cis-Retinoic Acid, and 15-Deoxy-{Delta}12,14-prostaglandin J2
J. Immunol., September 1, 2004; 173(5): 3165 - 3177.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. J. Nicol, M. Yoon, J. M. Ward, M. Yamashita, K. Fukamachi, J. M. Peters, and F. J. Gonzalez
PPAR{gamma} influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis
Carcinogenesis, September 1, 2004; 25(9): 1747 - 1755.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Sharma, A. Pradeep, L. Wong, A. Rana, and B. Rana
Peroxisome Proliferator-activated Receptor {gamma} Activation Can Regulate {beta}-Catenin Levels via a Proteasome-mediated and Adenomatous Polyposis Coli-independent Pathway
J. Biol. Chem., August 20, 2004; 279(34): 35583 - 35594.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Yang, C. J. Barnes, and R. Kumar
Human Epidermal Growth Factor Receptor 2 Status Modulates Subcellular Localization of and Interaction with Estrogen Receptor {alpha} in Breast Cancer Cells
Clin. Cancer Res., June 1, 2004; 10(11): 3621 - 3628.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. J. Kim, T. E. Akiyama, F. S. Harman, A. M. Burns, W. Shan, J. M. Ward, M. J. Kennett, F. J. Gonzalez, and J. M. Peters
Peroxisome Proliferator-activated Receptor {beta} ({delta})-dependent Regulation of Ubiquitin C Expression Contributes to Attenuation of Skin Carcinogenesis
J. Biol. Chem., May 28, 2004; 279(22): 23719 - 23727.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Sharma, A. Pradeep, R. G. Pestell, and B. Rana
Peroxisome Proliferator-activated Receptor {gamma} Activation Modulates Cyclin D1 Transcription via {beta}-Catenin-independent and cAMP-response Element-binding Protein-dependent Pathways in Mouse Hepatocytes
J. Biol. Chem., April 23, 2004; 279(17): 16927 - 16938.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. Qin, D. Morrow, J. Stewart, K. Spencer, W. Porter, R. Smith III, T. Phillips, M. Abdelrahim, I. Samudio, and S. Safe
A new class of peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes
Mol. Cancer Ther., March 1, 2004; 3(3): 247 - 260.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
P. Tanmahasamut, J. Liu, L. B. Hendry, and N. Sidell
Conjugated Linoleic Acid Blocks Estrogen Signaling in Human Breast Cancer Cells
J. Nutr., March 1, 2004; 134(3): 674 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Lapillonne, M. Konopleva, T. Tsao, D. Gold, T. McQueen, R. L. Sutherland, T. Madden, and M. Andreeff
Activation of Peroxisome Proliferator-activated Receptor {gamma} by a Novel Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Growth Arrest and Apoptosis in Breast Cancer Cells
Cancer Res., September 15, 2003; 63(18): 5926 - 5939.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.