Cancer Research Meeting Calendar Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bandyopadhyay, S.
Right arrow Articles by Watabe, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bandyopadhyay, S.
Right arrow Articles by Watabe, K.
[Cancer Research 63, 1731-1736, April 15, 2003]
© 2003 American Association for Cancer Research

Advances in Brief

The Drg-1 Gene Suppresses Tumor Metastasis in Prostate Cancer

Sucharita Bandyopadhyay, Sudha K. Pai, Steven C. Gross, Shigeru Hirota, Sadahiro Hosobe, Kunio Miura, Ken Saito, Therese Commes, Sunao Hayashi, Misako Watabe and Kounosuke Watabe1

Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, Illinois 62702 [S. B., S. K. P., S. C. G., M. W., K. W.]; Department of Pathology, Akita Red Cross Hospital, Akita City, Japan 010-1495 [S. Hi., S. Ho., K. M., K. S.]; Universite Montepillar II, Montepillar, France 34095 [T. C.]; and Department of Global Agricultural Science, University of Tokyo, Tokyo, Japan 113-8657 [S. Ha.]

Drg-1 was previously identified (N. van Belzen et al., Lab. Investig., 77: 85–92, 1997) as a gene that was up-regulated by the induction of differentiation in a colon carcinoma cell line in vitro. Subsequently, this gene was found to be regulated by several factors including hypoxia, androgen, p53, and N-myc. Recently, Drg-1 has also been shown to be involved in tumor progression in animals, although the clinical significance of its involvement remains to be investigated. To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry. We found that the expression of Drg-1 had a significant inverse correlation with the Gleason grading and the overall survival rate of patients. In particular, the gene expression in patients with lymph node or bone metastasis was significantly reduced as compared with those with localized prostate cancer, suggesting that the function of Drg-1 is negatively involved in metastatic progression of the disease. To further clarify the function of this gene in the advancement of prostate cancer, a spontaneous metastasis assay was performed in a severe combined immunodeficient (SCID) mouse model. We found that Drg-1 almost completely inhibited lung colonization of highly metastatic prostate cancer cells without affecting the growth of the primary tumors. These results strongly suggest that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may serve as a useful prognostic marker.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. H. Schilling, A. B. Hjelmeland, D. R. Radiloff, I. M. Liu, T. P. Wakeman, J. R. Fielhauer, E. H. Foster, J. D. Lathia, J. N. Rich, X.-F. Wang, et al.
NDRG4 Is Required for Cell Cycle Progression and Survival in Glioblastoma Cells
J. Biol. Chem., September 11, 2009; 284(37): 25160 - 25169.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Ambrosini, S. L. Seelman, and G. K. Schwartz
Differentiation-Related Gene-1 Decreases Bim Stability by Proteasome-Mediated Degradation
Cancer Res., August 1, 2009; 69(15): 6115 - 6121.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Genomics ProteomicsHome page
F. A. MALIK, A. J. SANDERS, M. A. KAYANI, and W. G. JIANG
Effect of Expressional Alteration of KAI1 on Breast Cancer Cell Growth, Adhesion, Migration and Invasion
Cancer Genomics Proteomics, July 1, 2009; 6(4): 205 - 213.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
V. Melotte, M. H. F. M. Lentjes, S. M. van den Bosch, D. M. E. I. Hellebrekers, J. P. J. de Hoon, K. A. D. Wouters, K. L. J. Daenen, I. E. J. M. Partouns-Hendriks, F. Stessels, J. Louwagie, et al.
N-Myc Downstream-Regulated Gene 4 (NDRG4): A Candidate Tumor Suppressor Gene and Potential Biomarker for Colorectal Cancer
J Natl Cancer Inst, July 1, 2009; 101(13): 916 - 927.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Hosoi, H. Izumi, A. Kawahara, Y. Murakami, H. Kinoshita, M. Kage, K. Nishio, K. Kohno, M. Kuwano, and M. Ono
N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of {kappa}B Kinase {beta} Expression
Cancer Res., June 15, 2009; 69(12): 4983 - 4991.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
H. Z. Li, Y. Gao, X. L. Zhao, Y. X. Liu, B. C. Sun, J. Yang, and Z. Yao
Effects of Raf Kinase Inhibitor Protein Expression on Metastasis and Progression of Human Breast Cancer
Mol. Cancer Res., June 1, 2009; 7(6): 832 - 840.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Q. Zhou, B. Yan, X. Hu, X.-B. Li, J. Zhang, and J. Fang
Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
Mol. Cancer Ther., June 1, 2009; 8(6): 1684 - 1691.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
M. SOHDA, Y. MOCHIDA, H. KATO, T. MIYAZAKI, M. NAKAJIMA, M. FUKUCHI, R. MANDA, Y. FUKAI, N. MASUDA, M. ONO, et al.
Overexpression of Cap43 is Associated with Malignant Status of Esophageal Cancer
Anticancer Res, April 1, 2009; 29(4): 965 - 970.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Scortegagna, R. J. Martin, R. D. Kladney, R. G. Neumann, and J. M. Arbeit
Hypoxia-Inducible Factor-1{alpha} Suppresses Squamous Carcinogenic Progression and Epithelial-Mesenchymal Transition
Cancer Res., March 15, 2009; 69(6): 2638 - 2646.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. J. Assinder, Q. Dong, H. Mangs, and D. R. Richardson
Pharmacological Targeting of the Integrated Protein Kinase B, Phosphatase and Tensin Homolog Deleted on Chromosome 10, and Transforming Growth Factor-{beta} Pathways in Prostate Cancer
Mol. Pharmacol., March 1, 2009; 75(3): 429 - 436.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Iiizumi, S. Bandyopadhyay, S. K. Pai, M. Watabe, S. Hirota, S. Hosobe, T. Tsukada, K. Miura, K. Saito, E. Furuta, et al.
RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer
Cancer Res., September 15, 2008; 68(18): 7613 - 7620.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
N. Liu, L. Wang, X. Li, Q. Yang, X. Liu, J. Zhang, J. Zhang, Y. Wu, S. Ji, Y. Zhang, et al.
N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis
Nucleic Acids Res., September 1, 2008; 36(16): 5335 - 5349.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. C. Lee, Y. K. Kang, W. H. Kim, Y. J. Jang, D. J. Kim, I. Y. Park, B. H. Sohn, H. A. Sohn, H. G. Lee, J. S. Lim, et al.
Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis
Cancer Res., June 1, 2008; 68(11): 4210 - 4220.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
T. Okuda, K. Kokame, and T. Miyata
Differential Expression Patterns of NDRG Family Proteins in the Central Nervous System
J. Histochem. Cytochem., February 1, 2008; 56(2): 175 - 182.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
T. P. Ellen, Q. Ke, P. Zhang, and M. Costa
NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states
Carcinogenesis, January 1, 2008; 29(1): 2 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Zhang, K.-M. Tchou-Wong, and M. Costa
Egr-1 Mediates Hypoxia-Inducible Transcription of the NDRG1 Gene through an Overlapping Egr-1/Sp1 Binding Site in the Promoter
Cancer Res., October 1, 2007; 67(19): 9125 - 9133.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Taketomi, K. Sunaga, S. Tanaka, M. Nakamura, S. Arata, T. Okuda, T.-C. Moon, H.-W. Chang, Y. Sugimoto, K. Kokame, et al.
Impaired Mast Cell Maturation and Degranulation and Attenuated Allergic Responses in Ndrg1-Deficient Mice
J. Immunol., June 1, 2007; 178(11): 7042 - 7053.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. M.R. Bhat and V. Setaluri
Microtubule-Associated Proteins as Targets in Cancer Chemotherapy
Clin. Cancer Res., May 15, 2007; 13(10): 2849 - 2854.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
L. C. Tu, X. Yan, L. Hood, and B. Lin
Proteomics Analysis of the Interactome of N-myc Downstream Regulated Gene 1 and Its Interactions with the Androgen Response Program in Prostate Cancer Cells
Mol. Cell. Proteomics, April 1, 2007; 6(4): 575 - 588.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Zhang, F. Li, X. Liu, L. Shen, J. Liu, J. Su, W. Zhang, Y. Deng, L. Wang, N. Liu, et al.
The Repression of Human Differentiation-related Gene NDRG2 Expression by Myc via Miz-1-dependent Interaction with the NDRG2 Core Promoter
J. Biol. Chem., December 22, 2006; 281(51): 39159 - 39168.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Bandyopadhyay, Y. Wang, R. Zhan, S. K. Pai, M. Watabe, M. Iiizumi, E. Furuta, S. Mohinta, W. Liu, S. Hirota, et al.
The Tumor Metastasis Suppressor Gene Drg-1 Down-regulates the Expression of Activating Transcription Factor 3 in Prostate Cancer
Cancer Res., December 15, 2006; 66(24): 11983 - 11990.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Z. Kovacevic and D. R. Richardson
The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer
Carcinogenesis, December 1, 2006; 27(12): 2355 - 2366.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Whitnall, J. Howard, P. Ponka, and D. R. Richardson
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
PNAS, October 3, 2006; 103(40): 14901 - 14906.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Maruyama, M. Ono, A. Kawahara, T. Yokoyama, Y. Basaki, M. Kage, S. Aoyagi, H. Kinoshita, and M. Kuwano
Tumor Growth Suppression in Pancreatic Cancer by a Putative Metastasis Suppressor Gene Cap43/NDRG1/Drg-1 through Modulation of Angiogenesis.
Cancer Res., June 15, 2006; 66(12): 6233 - 6242.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Fotovati, T. Fujii, M. Yamaguchi, M. Kage, K. Shirouzu, S. Oie, Y. Basaki, M. Ono, H. Yamana, and M. Kuwano
17{beta}-Estradiol Induces Down-Regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-Related and Metastasis Suppressor Gene, in Human Breast Cancer Cells.
Clin. Cancer Res., May 15, 2006; 12(10): 3010 - 3018.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Chen, D. M. Nelson, and Y. Sadovsky
N-Myc Down-regulated Gene 1 Modulates the Response of Term Human Trophoblasts to Hypoxic Injury
J. Biol. Chem., February 3, 2006; 281(5): 2764 - 2772.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
D. S. Kalinowski and D. R. Richardson
The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer
Pharmacol. Rev., December 1, 2005; 57(4): 547 - 583.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. J. Vander Griend, M. Kocherginsky, J. A. Hickson, W. M. Stadler, A. Lin, and C. W. Rinker-Schaeffer
Suppression of Metastatic Colonization by the Context-Dependent Activation of the c-Jun NH2-Terminal Kinase Kinases JNKK1/MKK4 and MKK7
Cancer Res., December 1, 2005; 65(23): 10984 - 10991.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
Z. Dong, R. J. Arnold, Y. Yang, M. H. Park, P. Hrncirova, Y. Mechref, M. V. Novotny, and J.-T. Zhang
Modulation of Differentiation-related Gene 1 Expression by Cell Cycle Blocker Mimosine, Revealed by Proteomic Analysis
Mol. Cell. Proteomics, July 1, 2005; 4(7): 993 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. A. Shah, J. Kortmansky, M. Motwani, M. Drobnjak, M. Gonen, S. Yi, A. Weyerbacher, C. Cordon-Cardo, R. Lefkowitz, B. Brenner, et al.
A Phase I Clinical Trial of the Sequential Combination of Irinotecan Followed by Flavopiridol
Clin. Cancer Res., May 15, 2005; 11(10): 3836 - 3845.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. A. Shah, N. Kemeny, A. Hummer, M. Drobnjak, M. Motwani, C. Cordon-Cardo, M. Gonen, and G. K. Schwartz
Drg1 Expression in 131 Colorectal Liver Metastases: Correlation with Clinical Variables and Patient Outcomes
Clin. Cancer Res., May 1, 2005; 11(9): 3296 - 3302.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
N Nathoo, A Chahlavi, G H Barnett, and S A Toms
Pathobiology of brain metastases
J. Clin. Pathol., March 1, 2005; 58(3): 237 - 242.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Stein, E. K. Thomas, B. Herzog, M. D. Westfall, J. V. Rocheleau, R. S. Jackson II, M. Wang, and P. Liang
NDRG1 Is Necessary for p53-dependent Apoptosis
J. Biol. Chem., November 19, 2004; 279(47): 48930 - 48940.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. Ang, M. Lijovic, L. K. Ashman, K. Kan, and A. G. Frauman
CD151 Protein Expression Predicts the Clinical Outcome of Low-Grade Primary Prostate Cancer Better than Histologic Grading: A New Prognostic Indicator?
Cancer Epidemiol. Biomarkers Prev., November 1, 2004; 13(11): 1717 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Bandyopadhyay, S. K. Pai, S. Hirota, S. Hosobe, T. Tsukada, K. Miura, Y. Takano, K. Saito, T. Commes, D. Piquemal, et al.
PTEN Up-Regulates the Tumor Metastasis Suppressor Gene Drg-1 in Prostate and Breast Cancer
Cancer Res., November 1, 2004; 64(21): 7655 - 7660.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. T.V. Le and D. R. Richardson
Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation
Blood, November 1, 2004; 104(9): 2967 - 2975.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-t. Kim, P. P. Ongusaha, Y.-K. Hong, S. K. Kurdistani, M. Nakamura, K. P. Lu, and S. W. Lee
Function of Drg1/Rit42 in p53-dependent Mitotic Spindle Checkpoint
J. Biol. Chem., September 10, 2004; 279(37): 38597 - 38602.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Okuda, Y. Higashi, K. Kokame, C. Tanaka, H. Kondoh, and T. Miyata
Ndrg1-Deficient Mice Exhibit a Progressive Demyelinating Disorder of Peripheral Nerves
Mol. Cell. Biol., May 1, 2004; 24(9): 3949 - 3956.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
P. S. Steeg
PERSPECTIVES ON CLASSIC ARTICLES: Metastasis Suppressor Genes
J Natl Cancer Inst, March 17, 2004; 96(6): E4 - E4.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.