Cancer Research Meeting Calendar Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mai, V.
Right arrow Articles by Hursting, S. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mai, V.
Right arrow Articles by Hursting, S. D.
[Cancer Research 63, 1752-1755, April 15, 2003]
© 2003 American Association for Cancer Research

Advances in Brief

Calorie Restriction and Diet Composition Modulate Spontaneous Intestinal Tumorigenesis in ApcMin Mice through Different Mechanisms1

Volker Mai, Lisa H. Colbert, David Berrigan, Susan N. Perkins, Ruth Pfeiffer, Jackie A. Lavigne, Elaine Lanza, Diana C. Haines, Arthur Schatzkin and Stephen D. Hursting2

Cancer Prevention Fellowship Program, Division of Cancer Prevention [V. M., D. B., S. N. P., J. A. L., S. D. H.], Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics [V. M., R. P., A. S.], Laboratory of Biosystems and Cancer, Center for Cancer Research [V. M., L. H. C., D. B., S. N. P., J. A. L., S. D. H.], and Applied Research Branch, Division of Cancer Control and Population Sciences [D. B.], National Cancer Institute, Bethesda, Maryland 20892; Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892 [L. H. C.]; Cancer Prevention Studies Branch, Center for Cancer Research, Bethesda, Maryland 20892 [E. L.]; and Pathology/Histotechnology Laboratory, Science Applications International Corporation–Frederick, Frederick, Maryland 21702 [D. C. H.]

We evaluated the effects of diet on intestinal tumorigenesis in male ApcMin mice by comparing AIN-76A diet fed ad libitum (CON); calorie intake restricted by 40% of the CON (CR); diet high in olive oil and supplemented with freeze-dried fruit and vegetable extracts (OFV); and diet high in total fat (HF). Compared with CON, the frequency of intestinal polyps was reduced by 57% by CR (P < 0.001) and by 33% OFV diet (P = 0.04). Both effective interventions reduced total body weight, lean mass, and fat mass and increased daily urinary corticosterone output, but only CR reduced serum insulin-like growth factor I and leptin. We conclude that dietary interventions can partially offset genetic susceptibility to intestinal carcinogenesis.




This article has been cited by other articles:


Home page
 Cancer Prevention ResearchHome page
K. A. Baltgalvis, F. G. Berger, M. M. O. Pena, J. M. Davis, and J. A. Carson
The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice
Cancer Prevention Research, July 1, 2009; 2(7): 641 - 649.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. Staiger, M. J. Lueben, D. Berrigan, R. Malik, S. N. Perkins, S. D. Hursting, and P. F. Johnson
C/EBP{beta} regulates body composition, energy balance-related hormones and tumor growth
Carcinogenesis, May 1, 2009; 30(5): 832 - 840.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. M. Birmingham, J. V. Busik, F. M. Hansen-Smith, and J. I. Fenton
Novel mechanism for obesity-induced colon cancer progression
Carcinogenesis, April 1, 2009; 30(4): 690 - 697.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. A. Varady, D. J. Roohk, B. K. McEvoy-Hein, B. D. Gaylinn, M. O. Thorner, and M. K. Hellerstein
Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice
FASEB J, June 1, 2008; 22(6): 2090 - 2096.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. J. Rogers, D. Berrigan, D. A. Zaharoff, K. W. Hance, A. C. Patel, S. N. Perkins, J. Schlom, J. W. Greiner, and S. D. Hursting
Energy Restriction and Exercise Differentially Enhance Components of Systemic and Mucosal Immunity in Mice
J. Nutr., January 1, 2008; 138(1): 115 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Zhu, W. Jiang, J. N. McGinley, J. M. Price, B. Gao, and H. J. Thompson
Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells
Cancer Res., December 15, 2007; 67(24): 12018 - 12025.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Xie, Y. Jiang, P. Ouyang, J. Chen, H. Doan, B. Herndon, J. E. Sylvester, K. Zhang, A. Molteni, M. Reichle, et al.
Effects of Dietary Calorie Restriction or Exercise on the PI3K and Ras Signaling Pathways in the Skin of Mice
J. Biol. Chem., September 21, 2007; 282(38): 28025 - 28035.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. A. Baran, K. A. Silverman, J. Zeskand, R. Koratkar, A. Palmer, K. McCullen, W. J. Curran Jr, T. B. Edmonston, L. D. Siracusa, and A. M. Buchberg
The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression
Genome Res., May 1, 2007; 17(5): 566 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. D. Hursting, N. P. Nunez, L. Varticovski, and C. Vinson
The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse
Cancer Res., March 15, 2007; 67(6): 2391 - 2393.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. H. Colbert, V. Mai, J. A. Tooze, S. N. Perkins, D. Berrigan, and S. D. Hursting
Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice
Carcinogenesis, October 1, 2006; 27(10): 2103 - 2107.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. I. Fenton, S. D. Hursting, S. N. Perkins, and N. G. Hord
Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line
Carcinogenesis, July 1, 2006; 27(7): 1507 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. Basterfield, J. M.H.M. Reul, and J. C. Mathers
Impact of Physical Activity on Intestinal Cancer Development in Mice
J. Nutr., December 1, 2005; 135(12): 3002S - 3008S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Zhu, W. Jiang, J. N. McGinley, and H. J. Thompson
2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on Mammary Carcinogenesis and on Mammary Tumor Cell Growth In vitro
Cancer Res., August 1, 2005; 65(15): 7023 - 7030.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Gu, C. J. Villegas, and J. X. Jiang
Differential Regulation of Amino Acid Transporter SNAT3 by Insulin in Hepatocytes
J. Biol. Chem., July 15, 2005; 280(28): 26055 - 26062.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Mehl, J. M. Davis, J. M. Clements, F. G. Berger, M. M. Pena, and J. A. Carson
Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice
J Appl Physiol, June 1, 2005; 98(6): 2219 - 2225.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. C. Patel, N. P. Nunez, S. N. Perkins, J. C. Barrett, and S. D. Hursting
Effects of Energy Balance on Cancer in Genetically Altered Mice
J. Nutr., December 1, 2004; 134(12): 3394S - 3398S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. D. Hursting, J. A. Lavigne, D. Berrigan, L. A. Donehower, B. J. Davis, J. M. Phang, J. C. Barrett, and S. N. Perkins
Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target
J. Nutr., September 1, 2004; 134(9): 2482S - 2486S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. J. Thompson, J. N. McGinley, N. S. Spoelstra, W. Jiang, Z. Zhu, and P. Wolfe
Effect of Dietary Energy Restriction on Vascular Density during Mammary Carcinogenesis
Cancer Res., August 15, 2004; 64(16): 5643 - 5650.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. P. Nunez, D. Jelovac, L. Macedo, D. Berrigan, S. N. Perkins, S. D. Hursting, J. C. Barrett, and A. Brodie
Effects of the Antiestrogen Tamoxifen and the Aromatase Inhibitor Letrozole on Serum Hormones and Bone Characteristics in a Preclinical Tumor Model for Breast Cancer
Clin. Cancer Res., August 15, 2004; 10(16): 5375 - 5380.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. M. Ward and D. E. Devor-Henneman
Mouse Models of Human Familial Cancer Syndromes
Toxicol Pathol, January 1, 2004; 32(1_suppl): 90 - 98.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.