Cancer Research Versailles No Abst Frontiers in Basic Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Su, Z.
Right arrow Articles by Vieweg, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Su, Z.
Right arrow Articles by Vieweg, J.
[Cancer Research 63, 2127-2133, May 1, 2003]
© 2003 American Association for Cancer Research

Experimental Therapeutics

Immunological and Clinical Responses in Metastatic Renal Cancer Patients Vaccinated with Tumor RNA-transfected Dendritic Cells1

Zhen Su2, Jens Dannull2, Axel Heiser, Donna Yancey, Scott Pruitt, John Madden, Doris Coleman, Donna Niedzwiecki, Eli Gilboa and Johannes Vieweg3

Cancer Immunotherapy Program, Division of Urology, Department of Surgery [Z. S., J. D., A. H., D. Y., D. C., J. V.], Center for Cellular and Genetic Therapies, Department of Surgery [S. P., E. G.], Department of Pathology [J. M.], and Department of Biostatistics [D. N.], Duke University Medical Center, Durham, North Carolina 27710

Autologous dendritic cells transfected with total renal tumor RNA have been shown to be potent stimulators of CTLs and antitumor immunity in vitro. A Phase I trial was conducted to evaluate this strategy for feasibility, safety, and efficacy to induce tumor-specific T-cell responses in subjects with metastatic renal cell carcinoma. Renal tumor RNA-transfected dendritic cells were administered to 10 evaluable study patients with no evidence of dose-limiting toxicity or vaccine-related adverse effects including autoimmunity. In six of seven evaluable subjects, expansion of tumor-specific T cells was detected after immunization. The vaccine-induced T-cell reactivities were directed against a broad set of renal tumor-associated antigens, including telomerase reverse transcriptase, G250, and oncofetal antigen, but not against self-antigens expressed by normal renal tissues. Although most patients underwent secondary therapies after vaccination, tumor-related mortality of the study subjects was unexpectedly low with only 3 of 10 patients dying from disease after a mean follow-up of 19.8 months. These data provide a scientific rationale for continued clinical investigation of this polyvalent vaccine strategy in the treatment of metastatic renal cell carcinoma and, potentially, other cancers.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
G. Almanzar, P. B. Olkhanud, M. Bodogai, C. Dell'Agnola, D. Baatar, S. M. Hewitt, C. Ghimenton, M. K. Tummala, A. T. Weeraratna, K. S. Hoek, et al.
Sperm-Derived SPANX-B Is a Clinically Relevant Tumor Antigen That Is Expressed in Human Tumors and Readily Recognized by Human CD4+ and CD8+ T Cells
Clin. Cancer Res., March 15, 2009; 15(6): 1954 - 1963.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. DeBenedette, D. M. Calderhead, H. Ketteringham, A. H. Gamble, J. M. Horvatinovich, I. Y. Tcherepanova, C. A. Nicolette, and D. G. Healey
Priming of a Novel Subset of CD28+ Rapidly Expanding High-Avidity Effector Memory CTL by Post Maturation Electroporation-CD40L Dendritic Cells Is IL-12 Dependent
J. Immunol., October 15, 2008; 181(8): 5296 - 5305.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Su, C. Frye, K.-M. Bae, V. Kelley, and J. Vieweg
Differentiation of Human Embryonic Stem Cells into Immunostimulatory Dendritic Cells under Feeder-Free Culture Conditions
Clin. Cancer Res., October 1, 2008; 14(19): 6207 - 6217.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
N. M. Melhem, S. M. Gleason, X. D. Liu, and S. M. Barratt-Boyes
High-Level Antigen Expression and Sustained Antigen Presentation in Dendritic Cells Nucleofected with Wild-Type Viral mRNA but Not DNA
Clin. Vaccine Immunol., September 1, 2008; 15(9): 1337 - 1344.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. M. Hipp, N. Hilf, S. Walter, D. Werth, K. M. Brauer, M. P. Radsak, T. Weinschenk, H. Singh-Jasuja, and P. Brossart
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
Blood, June 15, 2008; 111(12): 5610 - 5620.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kreiter, A. Selmi, M. Diken, M. Sebastian, P. Osterloh, H. Schild, C. Huber, O. Tureci, and U. Sahin
Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals
J. Immunol., January 1, 2008; 180(1): 309 - 318.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Dannull, D.-T. Lesher, R. Holzknecht, W. Qi, G. Hanna, H. Seigler, D. S. Tyler, and S. K. Pruitt
Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity
Blood, December 15, 2007; 110(13): 4341 - 4350.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Cools, P. Ponsaerts, V. F. I. Van Tendeloo, and Z. N. Berneman
Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells
J. Leukoc. Biol., December 1, 2007; 82(6): 1365 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Biragyn, R. Schiavo, P. Olkhanud, K. Sumitomo, A. King, M. McCain, F. E. Indig, G. Almanzar, and D. Baatar
Tumor-Associated Embryonic Antigen-Expressing Vaccines that Target CCR6 Elicit Potent CD8+ T Cell-Mediated Protective and Therapeutic Antitumor Immunity
J. Immunol., July 15, 2007; 179(2): 1381 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
Y. Ito, A. Demachi-Okamura, R. Ohta, Y. Akatsuka, K. Nishida, K. Tsujimura, Y. Morishima, T. Takahashi, and K. Kuzushima
Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells
J. Gen. Virol., March 1, 2007; 88(3): 770 - 780.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Parmiani, A. De Filippo, L. Novellino, and C. Castelli
Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials
J. Immunol., February 15, 2007; 178(4): 1975 - 1979.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. C. Yang and R. Childs
Immunotherapy for Renal Cell Cancer
J. Clin. Oncol., December 10, 2006; 24(35): 5576 - 5583.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
X. Cortez-Gonzalez, J. Sidney, O. Adotevi, A. Sette, F. Millard, F. Lemonnier, P. Langlade-Demoyen, and M. Zanetti
Immunogenic HLA-B7-restricted peptides of hTRT
Int. Immunol., December 1, 2006; 18(12): 1707 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Sensi and A. Anichini
Unique Tumor Antigens: Evidence for Immune Control of Genome Integrity and Immunogenic Targets for T Cell-Mediated Patient-Specific Immunotherapy
Clin. Cancer Res., September 1, 2006; 12(17): 5023 - 5032.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Tassi, V. Facchinetti, S. Seresini, A. Borri, G. Dell'Antonio, C. Garavaglia, G. Casorati, and M. P. Protti
Peptidome from Renal Cell Carcinoma Contains Antigens Recognized by CD4+ T Cells and Shared among Tumors of Different Histology.
Clin. Cancer Res., August 15, 2006; 12(16): 4949 - 4957.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. H.M.G.M. den Brok, R. P.M. Sutmuller, S. Nierkens, E. J. Bennink, L. W.J. Toonen, C. G. Figdor, T. J.M. Ruers, and G. J. Adema
Synergy between In situ Cryoablation and TLR9 Stimulation Results in a Highly Effective In vivo Dendritic Cell Vaccine.
Cancer Res., July 15, 2006; 66(14): 7285 - 7292.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Wierecky, M. R. Muller, S. Wirths, E. Halder-Oehler, D. Dorfel, S. M. Schmidt, M. Hantschel, W. Brugger, S. Schroder, M. S. Horger, et al.
Immunologic and Clinical Responses after Vaccinations with Peptide-Pulsed Dendritic Cells in Metastatic Renal Cancer Patients
Cancer Res., June 1, 2006; 66(11): 5910 - 5918.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. G. Kavanagh, D. E. Kaufmann, S. Sunderji, N. Frahm, S. Le Gall, D. Boczkowski, E. S. Rosenberg, D. R. Stone, M. N. Johnston, B. S. Wagner, et al.
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef
Blood, March 1, 2006; 107(5): 1963 - 1969.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
H. T. Cohen and F. J. McGovern
Renal-Cell Carcinoma
N. Engl. J. Med., December 8, 2005; 353(23): 2477 - 2490.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. Lennerz, M. Fatho, C. Gentilini, R. A. Frye, A. Lifke, D. Ferel, C. Wolfel, C. Huber, and T. Wolfel
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
PNAS, November 1, 2005; 102(44): 16013 - 16018.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Dorfel, S. Appel, F. Grunebach, M. M. Weck, M. R. Muller, A. Heine, and P. Brossart
Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA
Blood, April 15, 2005; 105(8): 3199 - 3205.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Dannull, S. Nair, Z. Su, D. Boczkowski, C. DeBeck, B. Yang, E. Gilboa, and J. Vieweg
Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand
Blood, April 15, 2005; 105(8): 3206 - 3213.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Su, J. Dannull, B. K. Yang, P. Dahm, D. Coleman, D. Yancey, S. Sichi, D. Niedzwiecki, D. Boczkowski, E. Gilboa, et al.
Telomerase mRNA-Transfected Dendritic Cells Stimulate Antigen-Specific CD8+ and CD4+ T Cell Responses in Patients with Metastatic Prostate Cancer
J. Immunol., March 15, 2005; 174(6): 3798 - 3807.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Frankenberger, H. Pohla, E. Noessner, G. Willimsky, B. Papier, A. Pezzutto, J. Kopp, R. Oberneder, T. Blankenstein, and D. J. Schendel
Influence of CD80, Interleukin-2, and Interleukin-7 Expression in Human Renal Cell Carcinoma on the Expansion, Function, and Survival of Tumor-Specific CTLs
Clin. Cancer Res., March 1, 2005; 11(5): 1733 - 1742.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Ishikawa, S. Motohashi, E. Ishikawa, H. Fuchida, K. Higashino, M. Otsuji, T. Iizasa, T. Nakayama, M. Taniguchi, and T. Fujisawa
A Phase I Study of {alpha}-Galactosylceramide (KRN7000)-Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer
Clin. Cancer Res., March 1, 2005; 11(5): 1910 - 1917.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
S. Cloosen, M. Thio, A. Vanclee, E. B. M. van Leeuwen, B. L. M. G. Senden-Gijsbers, E. B. H. Oving, W. T. V. Germeraad, and G. M. J. Bos
Mucin-1 is expressed on dendritic cells, both in vitro and in vivo
Int. Immunol., November 1, 2004; 16(11): 1561 - 1571.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. W. O'Neill, S. Adams, and N. Bhardwaj
Manipulating dendritic cell biology for the active immunotherapy of cancer
Blood, October 15, 2004; 104(8): 2235 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Avigan
Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma
Clin. Cancer Res., September 15, 2004; 10(18): 6347S - 6352S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. H. Coggin Jr., J. W. Rohrer, A. L. Barsoum, and J. Vieweg
True Immunogenicity of Oncofetal Antigen/Immature Laminin Receptor Protein
Cancer Res., July 1, 2004; 64(13): 4685 - 4685.
[Full Text] [PDF]

Home page
 Stem CellsHome page
A. Nencioni and P. Brossart
Cellular Immunotherapy with Dendritic Cells in Cancer: Current Status
Stem Cells, July 1, 2004; 22(4): 501 - 513.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Ebstein, C. Sapede, P.-J. Royer, M. Marcq, C. Ligeza-Poisson, I. Barbieux, L. Cellerin, G. Dabouis, and M. Gregoire
Cytotoxic T Cell Responses against Mesothelioma by Apoptotic Cell-pulsed Dendritic Cells
Am. J. Respir. Crit. Care Med., June 15, 2004; 169(12): 1322 - 1330.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Paczesny, J. Banchereau, K. M. Wittkowski, G. Saracino, J. Fay, and A. K. Palucka
Expansion of Melanoma-specific Cytolytic CD8+ T Cell Precursors in Patients with Metastatic Melanoma Vaccinated with CD34+ Progenitor-derived Dendritic Cells
J. Exp. Med., June 7, 2004; 199(11): 1503 - 1511.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. R. Saff, E. S. Spanjaard, A. M. Hohlbaum, and A. Marshak-Rothstein
Activation-Induced Cell Death Limits Effector Function of CD4 Tumor-Specific T Cells
J. Immunol., June 1, 2004; 172(11): 6598 - 6606.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Stift, M. Sachet, R. Yagubian, C. Bittermann, P. Dubsky, C. Brostjan, R. Pfragner, B. Niederle, R. Jakesz, M. Gnant, et al.
Dendritic Cell Vaccination in Medullary Thyroid Carcinoma
Clin. Cancer Res., May 1, 2004; 10(9): 2944 - 2953.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. M. Coughlin, B. A. Vance, S. A. Grupp, and R. H. Vonderheide
RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy
Blood, March 15, 2004; 103(6): 2046 - 2054.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.