This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bonnotte, B. Articles by Vile, R. G. Search for Related Content PubMed PubMed Citation Articles by Bonnotte, B. Articles by Vile, R. G.

Intradermal Injection, as Opposed to Subcutaneous Injection, Enhances Immunogenicity and Suppresses Tumorigenicity of Tumor Cells¹

Molecular Medicine Program, Guggenheim 18, Mayo Clinic, Rochester, Minnesota 55905 [B. B., M. G., V. P., A. A., H. C., R. G. V.], and INSERM U517, Faculty of Medicine, 21079 Dijon Cedex, France [B. B., F. M.]

Tumor cell immunogenicity depends heavily upon the microenvironment in which the cells grow. We have compared the tumorigenicity and immunogenicity of the same tumor cells when injected either into the dermis, a tissue containing numerous dendritic cells (DCs), or s.c., at a site which contains only few DCs. After s.c. injection, progressive tumors were constantly obtained, whereas most intradermal injections did not give rise to tumor and immunized animals against additional challenge. We present evidence that the high density of DCs at dermal sites facilitates the capture of tumor antigens and that local inflammation induces maturation of the DCs and their migration into draining lymph nodes.

This article has been cited by other articles:

				T. Kottke, J. Pulido, J. Thompson, L. Sanchez-Perez, H. Chong, S. K. Calderwood, P. Selby, K. Harrington, S. E. Strome, A. Melcher, et al. Antitumor Immunity Can Be Uncoupled from Autoimmunity following Heat Shock Protein 70-Mediated Inflammatory Killing of Normal Pancreas Cancer Res., October 1, 2009; 69(19): 7767 - 7774. [Abstract] [Full Text] [PDF]

				L. Sanchez-Perez, T. Kottke, G. A. Daniels, R. M. Diaz, J. Thompson, J. Pulido, A. Melcher, and R. G. Vile Killing of Normal Melanocytes, Combined with Heat Shock Protein 70 and CD40L Expression, Cures Large Established Melanomas J. Immunol., September 15, 2006; 177(6): 4168 - 4177. [Abstract] [Full Text] [PDF]

				T. L. Mikkelsen, E. Rasmussen, A. Olsen, V. Barkholt, and H. Frokiaer Immunogenicity of kappa-casein and glycomacropeptide. J Dairy Sci, March 1, 2006; 89(3): 824 - 830. [Abstract] [Full Text] [PDF]

				L. Sanchez-Perez, T. Kottke, R. M. Diaz, A. Ahmed, J. Thompson, H. Chong, A. Melcher, S. Holmen, G. Daniels, and R. G. Vile Potent Selection of Antigen Loss Variants of B16 Melanoma following Inflammatory Killing of Melanocytes In vivo Cancer Res., March 1, 2005; 65(5): 2009 - 2017. [Abstract] [Full Text] [PDF]

				X. Preville, D. Ladant, B. Timmerman, and C. Leclerc Eradication of Established Tumors by Vaccination With Recombinant Bordetella pertussis Adenylate Cyclase Carrying the Human Papillomavirus 16 E7 Oncoprotein Cancer Res., January 15, 2005; 65(2): 641 - 649. [Abstract] [Full Text] [PDF]

				C. Massa, C. Guiducci, I. Arioli, M. Parenza, M. P. Colombo, and C. Melani Enhanced Efficacy of Tumor Cell Vaccines Transfected with Secretable hsp70 Cancer Res., February 15, 2004; 64(4): 1502 - 1508. [Abstract] [Full Text] [PDF]