Cancer Research Annual Meeting 2010 Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ray, M. E.
Right arrow Articles by Ethier, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ray, M. E.
Right arrow Articles by Ethier, S. P.
[Cancer Research 64, 40-47, January 1, 2004]
© 2004 American Association for Cancer Research

Regular Articles

Genomic and Expression Analysis of the 8p11–12 Amplicon in Human Breast Cancer Cell Lines

Michael E. Ray1, Zeng Quan Yang1, Donna Albertson4, Celina G. Kleer3, Joseph G. Washburn3, Jill A. Macoska2 and Stephen P. Ethier1

1Departments of Radiation Oncology and 2Urology, 3Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, and 4Cancer Research Institute, University of California San Francisco, San Francisco, California

Gene amplification is an important mechanism of oncogene activation in breast and other cancers. Characterization of amplified regions of the genome in breast cancer has led to the identification of important oncogenes including erbB-2/HER-2, C-MYC, and fibroblast growth factor receptor (FGFR) 2. Chromosome 8p11-p12 is amplified in 10–15% of human breast cancers. The putative oncogene FGFR1 localizes to this region; however, we show evidence that FGFR inhibition fails to slow growth of three breast cancer cell lines with 8p11-p12 amplification. We present a detailed analysis of this amplicon in three human breast cancer cell lines using comparative genomic hybridization, traditional Southern and Northern analysis, and chromosome 8 cDNA microarray expression profiling. This study has identified new candidate oncogenes within the 8p11-p12 region, supporting the hypothesis that genes other than FGFR1 may contribute to oncogenesis in breast cancers with proximal 8p amplification.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
I. Bernard-Pierrot, N. Gruel, N. Stransky, A. Vincent-Salomon, F. Reyal, V. Raynal, C. Vallot, G. Pierron, F. Radvanyi, and O. Delattre
Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Cancer Res., September 1, 2008; 68(17): 7165 - 7175.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Q. Yang, K. L. Streicher, M. E. Ray, J. Abrams, and S. P. Ethier
Multiple Interacting Oncogenes on the 8p11-p12 Amplicon in Human Breast Cancer
Cancer Res., December 15, 2006; 66(24): 11632 - 11643.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. S. Reis-Filho, P. T. Simpson, N. C. Turner, M. B. Lambros, C. Jones, A. Mackay, A. Grigoriadis, D. Sarrio, K. Savage, T. Dexter, et al.
FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas.
Clin. Cancer Res., November 15, 2006; 12(22): 6652 - 6662.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
V. Gelsi-Boyer, B. Orsetti, N. Cervera, P. Finetti, F. Sircoulomb, C. Rouge, L. Lasorsa, A. Letessier, C. Ginestier, F. Monville, et al.
Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Mol. Cancer Res., December 1, 2005; 3(12): 655 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Tonon, K.-K. Wong, G. Maulik, C. Brennan, B. Feng, Y. Zhang, D. B. Khatry, A. Protopopov, M. J. You, A. J. Aguirre, et al.
High-resolution genomic profiles of human lung cancer
PNAS, July 5, 2005; 102(27): 9625 - 9630.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Reyal, N. Stransky, I. Bernard-Pierrot, A. Vincent-Salomon, Y. de Rycke, P. Elvin, A. Cassidy, A. Graham, C. Spraggon, Y. Desille, et al.
Visualizing Chromosomes as Transcriptome Correlation Maps: Evidence of Chromosomal Domains Containing Co-expressed Genes--A Study of 130 Invasive Ductal Breast Carcinomas
Cancer Res., February 15, 2005; 65(4): 1376 - 1383.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
G. TONON, C. BRENNAN, A. PROTOPOPOV, G. MAULIK, B. FENG, Y. ZHANG, D.B. KHATRY, M.J. YOU, A.J. AGUIRRE, E.S. MARTIN, et al.
Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes
Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 11 - 24.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
H. Tagawa, S. Tsuzuki, R. Suzuki, S. Karnan, A. Ota, Y. Kameoka, M. Suguro, K. Matsuo, M. Yamaguchi, M. Okamoto, et al.
Genome-Wide Array-Based Comparative Genomic Hybridization of Diffuse Large B-Cell Lymphoma: Comparison between CD5-Positive and CD5-Negative Cases
Cancer Res., September 1, 2004; 64(17): 5948 - 5955.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.