Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takei, Y.
Right arrow Articles by Muramatsu, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takei, Y.
Right arrow Articles by Muramatsu, T.
[Cancer Research 64, 3365-3370, May 15, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics

Yoshifumi Takei1, Kenji Kadomatsu1, Yukio Yuzawa2, Seiichi Matsuo2 and Takashi Muramatsu1

Departments of 1 Biochemistry and 2 Clinical Immunology of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan

Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. We developed a novel VEGF blockade system using RNA interference. The small interfering RNA (siRNA) targeting human VEGF almost completely inhibited the secretion of VEGF in a human prostate cancer cell line, PC-3, whereas the control scramble siRNA showed no effects. The VEGF siRNA with atelocollagen dramatically suppressed tumor angiogenesis and tumor growth in a PC-3 s.c. xenograft model. Atelocollagen provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved.




This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
E. Kawata, E. Ashihara, S. Kimura, K. Takenaka, K. Sato, R. Tanaka, A. Yokota, Y. Kamitsuji, M. Takeuchi, J. Kuroda, et al.
Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer
Mol. Cancer Ther., September 1, 2008; 7(9): 2904 - 2912.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Koldehoff, D. W. Beelen, and A. H. Elmaagacli
Small-molecule inhibition of proteasome and silencing by vascular endothelial cell growth factor-specific siRNA induce additive antitumor activity in multiple myeloma
J. Leukoc. Biol., August 1, 2008; 84(2): 561 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. de Martimprey, J.-R. Bertrand, A. Fusco, M. Santoro, P. Couvreur, C. Vauthier, and C. Malvy
siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
Nucleic Acids Res., January 17, 2008; 36(1): e2 - e2.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Y. Takei, T. Nemoto, P. Mu, T. Fujishima, T. Ishimoto, Y. Hayakawa, Y. Yuzawa, S. Matsuo, T. Muramatsu, and K. Kadomatsu
In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency
Mol. Cancer Ther., January 1, 2008; 7(1): 211 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Kokuryo, T. Senga, Y. Yokoyama, M. Nagino, Y. Nimura, and M. Hamaguchi
Nek2 as an Effective Target for Inhibition of Tumorigenic Growth and Peritoneal Dissemination of Cholangiocarcinoma
Cancer Res., October 15, 2007; 67(20): 9637 - 9642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Bhindi, R. G. Fahmy, H. C. Lowe, C. N. Chesterman, C. R. Dass, M. J. Cairns, E. G. Saravolac, L.-Q. Sun, and L. M. Khachigian
Brothers in Arms: DNA Enzymes, Short Interfering RNA, and the Emerging Wave of Small-Molecule Nucleic Acid-Based Gene-Silencing Strategies
Am. J. Pathol., October 1, 2007; 171(4): 1079 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Tazawa, N. Tsuchiya, M. Izumiya, and H. Nakagama
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
PNAS, September 25, 2007; 104(39): 15472 - 15477.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. K. Pulukuri and J. S. Rao
Small Interfering RNA Directed Reversal of Urokinase Plasminogen Activator Demethylation Inhibits Prostate Tumor Growth and Metastasis
Cancer Res., July 15, 2007; 67(14): 6637 - 6646.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Funasaka, H. Hu, T. Yanagawa, V. Hogan, and A. Raz
Down-Regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Results in Mesenchymal-to-Epithelial Transition of Human Lung Fibrosarcoma Cells
Cancer Res., May 1, 2007; 67(9): 4236 - 4243.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Tanaka, Y. Hashimoto, T. Ito, K. Kondo, M. Higashiyama, S. Tsunoda, C. Ortiz, Y. Sakai, J. Inazawa, and Y. Shimada
The Suppression of Aurora-A/STK15/BTAK Expression Enhances Chemosensitivity to Docetaxel in Human Esophageal Squamous Cell Carcinoma
Clin. Cancer Res., February 15, 2007; 13(4): 1331 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Li, Z. Gang, H. Yuling, X. Luokun, X. Jie, L. Hao, W. Li, H. Chunsong, L. Junyan, J. Mingshen, et al.
Different Neurotropic Pathogens Elicit Neurotoxic CCR9- or Neurosupportive CXCR3-Expressing Microglia
J. Immunol., September 15, 2006; 177(6): 3644 - 3656.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Shi, M. Zou, K. Collison, E. Y. Baitei, Z. Al-Makhalafi, N. R. Farid, and F. A. Al-Mohanna
Ribonucleic Acid Interference Targeting S100A4 (Mts1) Suppresses Tumor Growth and Metastasis of Anaplastic Thyroid Carcinoma in a Mouse Model
J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2373 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. J. Garton, A. P.A. Crew, M. Franklin, A. R. Cooke, G. M. Wynne, L. Castaldo, J. Kahler, S. L. Winski, A. Franks, E. N. Brown, et al.
OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Cancer Res., January 15, 2006; 66(2): 1015 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Hu-Lieskovan, J. D. Heidel, D. W. Bartlett, M. E. Davis, and T. J. Triche
Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma
Cancer Res., October 1, 2005; 65(19): 8984 - 8992.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Takeshita, Y. Minakuchi, S. Nagahara, K. Honma, H. Sasaki, K. Hirai, T. Teratani, N. Namatame, Y. Yamamoto, K. Hanai, et al.
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
PNAS, August 23, 2005; 102(34): 12177 - 12182.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Hata, T. Furukawa, M. Sunamura, S. Egawa, F. Motoi, N. Ohmura, T. Marumoto, H. Saya, and A. Horii
RNA Interference Targeting Aurora Kinase A Suppresses Tumor Growth and Enhances the Taxane Chemosensitivity in Human Pancreatic Cancer Cells
Cancer Res., April 1, 2005; 65(7): 2899 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Liang, Y. Yoon, J. Votaw, M. M. Goodman, L. Williams, and H. Shim
Silencing of CXCR4 Blocks Breast Cancer Metastasis
Cancer Res., February 1, 2005; 65(3): 967 - 971.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
R. M. Schiffelers, A. Ansari, J. Xu, Q. Zhou, Q. Tang, G. Storm, G. Molema, P. Y. Lu, P. V. Scaria, and M. C. Woodle
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
Nucleic Acids Res., November 1, 2004; 32(19): e149 - e149.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Minakuchi, F. Takeshita, N. Kosaka, H. Sasaki, Y. Yamamoto, M. Kouno, K. Honma, S. Nagahara, K. Hanai, A. Sano, et al.
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
Nucleic Acids Res., July 22, 2004; 32(13): e109 - e109.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.