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[Cancer Research 64, 3371-3375, May 15, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

The HMG-I Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human Leukemia

Yi Xu1,2,3, Takita Felder Sumter1,2,3, Raka Bhattacharya1,2,3, Abeba Tesfaye1,2,3, Ephraim J. Fuchs3, Lisa J. Wood1,2,3, David L. Huso4 and Linda M. S. Resar1,2,3

1 Hematology Division, 2 Departments of Pediatrics, 3 Oncology, and 4 Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland

HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.




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Molecular Cancer Research Cancer Prevention Research
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Copyright © 2004 by the American Association for Cancer Research.