Cancer Research The Future of Cancer Research: Science and Patient Impact Cancer Health Disparities Conference 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tong, R. T.
Right arrow Articles by Jain, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tong, R. T.
Right arrow Articles by Jain, R. K.
[Cancer Research 64, 3731-3736, June 1, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

Ricky T. Tong1,2, Yves Boucher1, Sergey V. Kozin1, Frank Winkler1, Daniel J. Hicklin3 and Rakesh K. Jain1

1 E. L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; 2 The Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts; and 3 ImClone Systems, Incorporated, New York, New York

Elevated interstitial fluid pressure, a hallmark of solid tumors, can compromise the delivery of therapeutics to tumors. Here we show that blocking vascular endothelial growth factor (VEGF) signaling by DC101 (a VEGF-receptor-2 antibody) decreases interstitial fluid pressure, not by restoring lymphatic function, but by producing a morphologically and functionally "normalized" vascular network. We demonstrate that the normalization process prunes immature vessels and improves the integrity and function of the remaining vasculature by enhancing the perivascular cell and basement membrane coverage. We also show that DC101 induces a hydrostatic pressure gradient across the vascular wall, which leads to a deeper penetration of molecules into tumors. Thus, vascular normalization may contribute to the improved survival rates in tumor-bearing animals and in colorectal carcinoma patients treated with an anti-VEGF antibody in combination with cytotoxic therapies.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
C. R. Schnell, F. Stauffer, P. R. Allegrini, T. O'Reilly, P. M.J. McSheehy, C. Dartois, M. Stumm, R. Cozens, A. Littlewood-Evans, C. Garcia-Echeverria, et al.
Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging
Cancer Res., August 15, 2008; 68(16): 6598 - 6607.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Bhattacharya, M. Seshadri, S. D. Oven, K. Toth, M. M. Vaughan, and Y. M. Rustum
Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs
Clin. Cancer Res., June 15, 2008; 14(12): 3926 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
V. K. Puduvalli, P. Giglio, M. D. Groves, K. R. Hess, M. R. Gilbert, S. Mahankali, E. F. Jackson, V. A. Levin, C. A. Conrad, S. H. Hsu, et al.
Phase II trial of irinotecan and thalidomide in adults with recurrent glioblastoma multiforme
Neuro-oncol, April 1, 2008; 10(2): 216 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Q. Zhou, P. Guo, and J. M. Gallo
Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide
Clin. Cancer Res., March 1, 2008; 14(5): 1540 - 1549.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. M. Thomas, M. J. Ogagan, M. L. Freilino, S. Strychor, D. R. Walsh, W. E. Gooding, J. R. Grandis, and W. C. Zamboni
Antitumor Mechanisms of Systemically Administered Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck
Mol. Pharmacol., March 1, 2008; 73(3): 627 - 638.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
A. Kadenhe-Chiweshe, J. Papa, K. W. McCrudden, J. Frischer, J.-O Bae, J. Huang, J. Fisher, J. H. Lefkowitch, N. Feirt, J. Rudge, et al.
Sustained VEGF Blockade Results in Microenvironmental Sequestration of VEGF by Tumors and Persistent VEGF Receptor-2 Activation
Mol. Cancer Res., January 1, 2008; 6(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Ma and D. J. Waxman
Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib
Mol. Cancer Ther., January 1, 2008; 7(1): 79 - 89.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. J. Vredenburgh, A. Desjardins, J. E. Herndon II, J. Marcello, D. A. Reardon, J. A. Quinn, J. N. Rich, S. Sathornsumetee, S. Gururangan, J. Sampson, et al.
Bevacizumab Plus Irinotecan in Recurrent Glioblastoma Multiforme
J. Clin. Oncol., October 20, 2007; 25(30): 4722 - 4729.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. M. Fenton and S. F. Paoni
The Addition of AG-013736 to Fractionated Radiation Improves Tumor Response without Functionally Normalizing the Tumor Vasculature
Cancer Res., October 15, 2007; 67(20): 9921 - 9928.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. C. Friedland, J. N. Lakins, M. G. Kazanietz, J. Chernoff, D. Boettiger, and V. M. Weaver
{alpha}6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-{kappa}B-dependent resistance to apoptosis in 3D mammary acini
J. Cell Sci., October 15, 2007; 120(20): 3700 - 3712.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
O. Tredan, C. M. Galmarini, K. Patel, and I. F. Tannock
Drug Resistance and the Solid Tumor Microenvironment
J Natl Cancer Inst, October 3, 2007; 99(19): 1441 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. L.B. Seynhaeve, S. Hoving, D. Schipper, C. E. Vermeulen, G. aan de Wiel-Ambagtsheer, S. T. van Tiel, A. M.M. Eggermont, and T. L.M. ten Hagen
Tumor Necrosis Factor {alpha} Mediates Homogeneous Distribution of Liposomes in Murine Melanoma that Contributes to a Better Tumor Response
Cancer Res., October 1, 2007; 67(19): 9455 - 9462.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. D. Mocanu, K. W. Yip, J. Skliarenko, W. Shi, P. Busson, K.-W. Lo, C. Bastianutto, and F.-F. Liu
Imaging and Modulating Antisense Microdistribution in Solid Human Xenograft Tumor Models
Clin. Cancer Res., October 1, 2007; 13(19): 5935 - 5941.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. G. Duda, R. K. Jain, and C. G. Willett
Antiangiogenics: The Potential Role of Integrating This Novel Treatment Modality With Chemoradiation for Solid Cancers
J. Clin. Oncol., September 10, 2007; 25(26): 4033 - 4042.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
O. Riesterer, L. Milas, and K. K. Ang
Use of Molecular Biomarkers for Predicting the Response to Radiotherapy With or Without Chemotherapy
J. Clin. Oncol., September 10, 2007; 25(26): 4075 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
N. R. Smith, N. H. James, I. Oakley, A. Wainwright, C. Copley, J. Kendrew, L. M. Womersley, J. M. Jurgensmeier, S. R. Wedge, and S. T. Barry
Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts
Mol. Cancer Ther., August 1, 2007; 6(8): 2198 - 2208.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Potikyan, R. O.V. Savene, J. M. Gaulden, K. A. France, Z. Zhou, E. S. Kleinerman, S. L. Lessnick, and C. T. Denny
EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins
Cancer Res., July 15, 2007; 67(14): 6675 - 6684.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
N. Tang, G. Du, N. Wang, C. Liu, H. Hang, and W. Liang
Improving Penetration in Tumors With Nanoassemblies of Phospholipids and Doxorubicin
J Natl Cancer Inst, July 4, 2007; 99(13): 1004 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. Lu, M. G. Wientjes, Z. Lu, and J. L.-S. Au
Tumor Priming Enhances Delivery and Efficacy of Nanomedicines
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 80 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Jinushi and G. Dranoff
Triggering Tumor Immunity through Angiogenesis Targeting
Clin. Cancer Res., July 1, 2007; 13(13): 3762 - 3764.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. V. Dickson, J. B. Hamner, T. L. Sims, C. H. Fraga, C. Y.C. Ng, S. Rajasekeran, N. L. Hagedorn, M. B. McCarville, C. F. Stewart, and A. M. Davidoff
Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy
Clin. Cancer Res., July 1, 2007; 13(13): 3942 - 3950.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. A. Manning, J. G.M. Ullman, J. M. Leatherman, J. M. Asquith, T. R. Hansen, T. D. Armstrong, D. J. Hicklin, E. M. Jaffee, and L. A. Emens
A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism
Clin. Cancer Res., July 1, 2007; 13(13): 3951 - 3959.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. L. Muldoon, C. Soussain, K. Jahnke, C. Johanson, T. Siegal, Q. R. Smith, W. A. Hall, K. Hynynen, P. D. Senter, D. M. Peereboom, et al.
Chemotherapy Delivery Issues in Central Nervous System Malignancy: A Reality Check
J. Clin. Oncol., June 1, 2007; 25(16): 2295 - 2305.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. V. Kozin, F. Winkler, I. Garkavtsev, D. J. Hicklin, R. K. Jain, and Y. Boucher
Human Tumor Xenografts Recurring after Radiotherapy Are More Sensitive to Anti-Vascular Endothelial Growth Factor Receptor-2 Treatment than Treatment-Naive Tumors
Cancer Res., June 1, 2007; 67(11): 5076 - 5082.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. K. Jain, R. T. Tong, and L. L. Munn
Effect of Vascular Normalization by Antiangiogenic Therapy on Interstitial Hypertension, Peritumor Edema, and Lymphatic Metastasis: Insights from a Mathematical Model
Cancer Res., March 15, 2007; 67(6): 2729 - 2735.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Jain, G. Venkatraman, and S. K. Batra
Optimization of Radioimmunotherapy of Solid Tumors: Biological Impediments and Their Modulation
Clin. Cancer Res., March 1, 2007; 13(5): 1374 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. J. Vredenburgh, A. Desjardins, J. E. Herndon II, J. M. Dowell, D. A. Reardon, J. A. Quinn, J. N. Rich, S. Sathornsumetee, S. Gururangan, M. Wagner, et al.
Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma
Clin. Cancer Res., February 15, 2007; 13(4): 1253 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. J. Williams, B. A. Telfer, A. M. Shannon, M. Babur, I. J. Stratford, and S. R. Wedge
Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit
Mol. Cancer Ther., February 1, 2007; 6(2): 599 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. R. Horsman and D. W. Siemann
Pathophysiologic Effects of Vascular-Targeting Agents and the Implications for Combination with Conventional Therapies
Cancer Res., December 15, 2006; 66(24): 11520 - 11539.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. P. Hall
Review of the Pericyte during Angiogenesis and its Role in Cancer and Diabetic Retinopathy
Toxicol Pathol, October 1, 2006; 34(6): 763 - 775.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Ansiaux, C. Baudelet, B. F. Jordan, N. Crokart, P. Martinive, J. DeWever, V. Gregoire, O. Feron, and B. Gallez
Mechanism of Reoxygenation after Antiangiogenic Therapy Using SU5416 and Its Importance for Guiding Combined Antitumor Therapy
Cancer Res., October 1, 2006; 66(19): 9698 - 9704.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
P. J. O'Dwyer
The Present and Future of Angiogenesis-Directed Treatments of Colorectal Cancer
Oncologist, October 1, 2006; 11(9): 992 - 998.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. E. Holloway, A. W. Beck, L. Shivakumar, J. Shih, J. B. Fleming, and R. A. Brekken
Selective Blockade of Vascular Endothelial Growth Factor Receptor 2 With an Antibody Against Tumor-Derived Vascular Endothelial Growth Factor Controls the Growth of Human Pancreatic Adenocarcinoma Xenografts
Ann. Surg. Oncol., August 1, 2006; 13(8): 1145 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Muruganandham, M. Lupu, J. P. Dyke, C. Matei, M. Linn, K. Packman, K. Kolinsky, B. Higgins, and J. A. Koutcher
Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T.
Mol. Cancer Ther., August 1, 2006; 5(8): 1950 - 1957.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Dome, J. Timar, J. Dobos, L. Meszaros, E. Raso, S. Paku, I. Kenessey, G. Ostoros, M. Magyar, A. Ladanyi, et al.
Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer.
Cancer Res., July 15, 2006; 66(14): 7341 - 7347.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Jones-Bolin, H. Zhao, K. Hunter, A. Klein-Szanto, and B. Ruggeri
The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice.
Mol. Cancer Ther., July 1, 2006; 5(7): 1744 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. G. Duda
Antiangiogenesis and drug delivery to tumors: bench to bedside and back.
Cancer Res., April 15, 2006; 66(8): 3967 - 3970.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Hassid, E. Furman-Haran, R. Margalit, R. Eilam, and H. Degani
Noninvasive magnetic resonance imaging of transport and interstitial fluid pressure in ectopic human lung tumors.
Cancer Res., April 15, 2006; 66(8): 4159 - 4166.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. R. Camp, A. Yang, W. Liu, F. Fan, R. Somcio, D. J. Hicklin, and L. M. Ellis
Roles of Nitric Oxide Synthase Inhibition and Vascular Endothelial Growth Factor Receptor-2 Inhibition on Vascular Morphology and Function in an In vivo Model of Pancreatic Cancer
Clin. Cancer Res., April 15, 2006; 12(8): 2628 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Hagendoorn, R. Tong, D. Fukumura, Q. Lin, J. Lobo, T. P. Padera, L. Xu, R. Kucherlapati, and R. K. Jain
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res., April 1, 2006; 66(7): 3360 - 3364.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Nakahara, S. M. Norberg, D. R. Shalinsky, D. D. Hu-Lowe, and D. M. McDonald
Effect of Inhibition of Vascular Endothelial Growth Factor Signaling on Distribution of Extravasated Antibodies in Tumors
Cancer Res., February 1, 2006; 66(3): 1434 - 1445.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Betsholtz and A. Armulik
Homeostatic functions of vascular endothelial growth factor in adult microvasculature
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H509 - H511.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. J. Primeau, A. Rendon, D. Hedley, L. Lilge, and I. F. Tannock
The Distribution of the Anticancer Drug Doxorubicin in Relation to Blood Vessels in Solid Tumors
Clin. Cancer Res., December 15, 2005; 11(24): 8782 - 8788.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Yokoi, T. Sasaki, C. D. Bucana, D. Fan, C. H. Baker, Y. Kitadai, T. Kuwai, J. L. Abbruzzese, and I. J. Fidler
Simultaneous Inhibition of EGFR, VEGFR, and Platelet-Derived Growth Factor Receptor Signaling Combined with Gemcitabine Produces Therapy of Human Pancreatic Carcinoma and Prolongs Survival in an Orthotopic Nude Mouse Model
Cancer Res., November 15, 2005; 65(22): 10371 - 10380.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. D. Loberg, C. J. Logothetis, E. T. Keller, and K. J. Pienta
Pathogenesis and Treatment of Prostate Cancer Bone Metastases: Targeting the Lethal Phenotype
J. Clin. Oncol., November 10, 2005; 23(32): 8232 - 8241.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. G. Willett, Y. Boucher, D. G. Duda, E. di Tomaso, L. L. Munn, R. T. Tong, S. V. Kozin, L. Petit, R. K. Jain, D. C. Chung, et al.
Surrogate Markers for Antiangiogenic Therapy and Dose-Limiting Toxicities for Bevacizumab With Radiation and Chemotherapy: Continued Experience of a Phase I Trial in Rectal Cancer Patients
J. Clin. Oncol., November 1, 2005; 23(31): 8136 - 8139.
[Full Text] [PDF]

Home page
 RadiologyHome page
Z. Kan, S. Phongkitkarun, S. Kobayashi, Y. Tang, L. M. Ellis, T. Y. Lee, and C. Charnsangavej
Functional CT for Quantifying Tumor Perfusion in Antiangiogenic Therapy in a Rat Model
Radiology, October 1, 2005; 237(1): 151 - 158.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. S. Rugo, R. S. Herbst, G. Liu, J. W. Park, M. S. Kies, H. M. Steinfeldt, Y. K. Pithavala, S. D. Reich, J. L. Freddo, and G. Wilding
Phase I Trial of the Oral Antiangiogenesis Agent AG-013736 in Patients With Advanced Solid Tumors: Pharmacokinetic and Clinical Results
J. Clin. Oncol., August 20, 2005; 23(24): 5474 - 5483.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. H. Thaker, S. Yazici, M. B. Nilsson, K. Yokoi, R. Z. Tsan, J. He, S.-J. Kim, I. J. Fidler, and A. K. Sood
Antivascular Therapy for Orthotopic Human Ovarian Carcinoma through Blockade of the Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptors
Clin. Cancer Res., July 1, 2005; 11(13): 4923 - 4933.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Zips, W. Eicheler, P. Geyer, F. Hessel, A. Dorfler, H. D. Thames, M. Haberey, and M. Baumann
Enhanced Susceptibility of Irradiated Tumor Vessels to Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibition
Cancer Res., June 15, 2005; 65(12): 5374 - 5379.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. E. Huber, M. Bischof, J. Jenne, S. Heiland, P. Peschke, R. Saffrich, H.-J. Grone, J. Debus, K. E. Lipson, and A. Abdollahi
Trimodal Cancer Treatment: Beneficial Effects of Combined Antiangiogenesis, Radiation, and Chemotherapy
Cancer Res., May 1, 2005; 65(9): 3643 - 3655.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. A. Khawli, P. Hu, and A. L. Epstein
NHS76/PEP2, a Fully Human Vasopermeability-Enhancing Agent to Increase The Uptake and Efficacy of Cancer Chemotherapy
Clin. Cancer Res., April 15, 2005; 11(8): 3084 - 3093.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
L. M. Ellis
Challenges in Translating Antiangiogenic Therapy from Bench to Bedside
Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 74 - 77.
[Full Text] [PDF]

Home page
 aacredbookHome page
R. K. Jain
Interstitial Transport in Tumors: Barriers and Strategies for Improvement
Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 108 - 113.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. S. Nathan, G. R. DiResta, J. E. Casas-Ganem, B. H. Hoang, R. Sowers, R. Yang, A. G. Huvos, R. Gorlick, and J. H. Healey
Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma
Clin. Cancer Res., March 15, 2005; 11(6): 2389 - 2397.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Vosseler, N. Mirancea, P. Bohlen, M. M. Mueller, and N. E. Fusenig
Angiogenesis Inhibition by Vascular Endothelial Growth Factor Receptor-2 Blockade Reduces Stromal Matrix Metalloproteinase Expression, Normalizes Stromal Tissue, and Reverts Epithelial Tumor Phenotype in Surface Heterotransplants
Cancer Res., February 15, 2005; 65(4): 1294 - 1305.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. J. Hicklin and L. M. Ellis
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
J. Clin. Oncol., February 10, 2005; 23(5): 1011 - 1027.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H.-P. Gerber and N. Ferrara
Pharmacology and Pharmacodynamics of Bevacizumab as Monotherapy or in Combination with Cytotoxic Therapy in Preclinical Studies
Cancer Res., February 1, 2005; 65(3): 671 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Ansiaux, C. Baudelet, B. F. Jordan, N. Beghein, P. Sonveaux, J. De Wever, P. Martinive, V. Gregoire, O. Feron, and B. Gallez
Thalidomide Radiosensitizes Tumors through Early Changes in the Tumor Microenvironment
Clin. Cancer Res., January 15, 2005; 11(2): 743 - 750.
[Abstract] [Full Text] [PDF]