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[Cancer Research 64, 3753-3756, June 1, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

Junichi Takamizawa1,4, Hiroyuki Konishi1, Kiyoshi Yanagisawa1, Shuta Tomida1, Hirotaka Osada1, Hideki Endoh3, Tomoko Harano1, Yasushi Yatabe2, Masato Nagino4, Yuji Nimura4, Tetsuya Mitsudomi3 and Takashi Takahashi1

1 Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan; Departments of 2 Anatomic and Molecular Diagnostic Pathology and 3 Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan; 4 Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.




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Home page
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Home page
 J. Clin. Pathol.Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Y. Hiyoshi, H. Kamohara, R. Karashima, N. Sato, Y. Imamura, Y. Nagai, N. Yoshida, E. Toyama, N. Hayashi, M. Watanabe, et al.
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
PNAS, March 3, 2009; 106(9): 3384 - 3389.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
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MicroRNA-mediated Regulation of Ubc9 Expression in Cancer Cells
Clin. Cancer Res., March 1, 2009; 15(5): 1550 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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Regulation of Epidermal Growth Factor Receptor Signaling in Human Cancer Cells by MicroRNA-7
J. Biol. Chem., February 27, 2009; 284(9): 5731 - 5741.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
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Bioinformatics, February 15, 2009; 25(4): 430 - 434.
[Abstract] [Full Text] [PDF]

Home page
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Common Themes of Dedifferentiation in Somatic Cell Reprogramming and Cancer
Cold Spring Harb Symp Quant Biol, January 15, 2009; (2009) sqb.2008.73.041v1.
[Abstract] [PDF]

Home page
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Integrating the MicroRNome into the Study of Lung Disease
Am. J. Respir. Crit. Care Med., January 1, 2009; 179(1): 4 - 10.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
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N. Engl. J. Med., December 18, 2008; 359(25): 2720 - 2722.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
S. A. Georges, M. C. Biery, S.-y. Kim, J. M. Schelter, J. Guo, A. N. Chang, A. L. Jackson, M. O. Carleton, P. S. Linsley, M. A. Cleary, et al.
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Cancer Res., December 15, 2008; 68(24): 10105 - 10112.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Yang, S. Kaur, S. Volinia, J. Greshock, H. Lassus, K. Hasegawa, S. Liang, A. Leminen, S. Deng, L. Smith, et al.
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Home page
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Mol. Cancer Res., December 1, 2008; 6(12): 1830 - 1840.
[Abstract] [Full Text] [PDF]

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Carcinogenesis, December 1, 2008; 29(12): 2394 - 2399.
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Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., November 28, 2008; 283(48): 33394 - 33405.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. L. Yeung, J.-i. Yasunaga, Y. Bennasser, N. Dusetti, D. Harris, N. Ahmad, M. Matsuoka, and K.-T. Jeang
Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53-Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1
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[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
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MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
RNA, November 1, 2008; 14(11): 2348 - 2360.
[Abstract] [Full Text] [PDF]

Home page
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let-7 regulates Dicer expression and constitutes a negative feedback loop
Carcinogenesis, November 1, 2008; 29(11): 2073 - 2077.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. J. Chin, E. Ratner, S. Leng, R. Zhai, S. Nallur, I. Babar, R.-U. Muller, E. Straka, L. Su, E. A. Burki, et al.
A SNP in a let-7 microRNA Complementary Site in the KRAS 3' Untranslated Region Increases Non-Small Cell Lung Cancer Risk
Cancer Res., October 15, 2008; 68(20): 8535 - 8540.
[Abstract] [Full Text] [PDF]

Home page
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Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans
RNA, October 1, 2008; 14(10): 2104 - 2114.
[Abstract] [Full Text] [PDF]

Home page
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Prognostic Value of Mature MicroRNA-21 and MicroRNA-205 Overexpression in Non-Small Cell Lung Cancer by Quantitative Real-Time RT-PCR
Clin. Chem., October 1, 2008; 54(10): 1696 - 1704.
[Abstract] [Full Text] [PDF]

Home page
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miR-34a repression of SIRT1 regulates apoptosis
PNAS, September 9, 2008; 105(36): 13421 - 13426.
[Abstract] [Full Text] [PDF]

Home page
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Carcinogenesis, September 1, 2008; 29(9): 1710 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
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The Emergent Role of MicroRNAs in Molecular Diagnostics of Cancer
J. Mol. Diagn., September 1, 2008; 10(5): 411 - 414.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
Z. Yu, C. Wang, M. Wang, Z. Li, M. C. Casimiro, M. Liu, K. Wu, J. Whittle, X. Ju, T. Hyslop, et al.
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
J. Cell Biol., August 11, 2008; 182(3): 509 - 517.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28
J. Biol. Chem., August 1, 2008; 283(31): 21310 - 21314.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
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Home page
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Blood, May 15, 2008; 111(10): 5078 - 5085.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., May 9, 2008; 283(19): 13205 - 13215.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
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[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
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MicroRNA Expression Profiles in Serous Ovarian Carcinoma
Clin. Cancer Res., May 1, 2008; 14(9): 2690 - 2695.
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Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Sengupta, J. A. den Boon, I-H. Chen, M. A. Newton, S. A. Stanhope, Y.-J. Cheng, C.-J. Chen, A. Hildesheim, B. Sugden, and P. Ahlquist
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
PNAS, April 15, 2008; 105(15): 5874 - 5878.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
K. Motoyama, H. Inoue, Y. Nakamura, H. Uetake, K. Sugihara, and M. Mori
Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to let-7 MicroRNA Family
Clin. Cancer Res., April 15, 2008; 14(8): 2334 - 2340.
[Abstract] [Full Text] [PDF]

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 aacredbookHome page
G. A. Calin and C. M. Croce
MicroRNA-Cancer Connection: The Beginning of a New Tale
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 667 - 675.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
S.-M. Park, A. B. Gaur, E. Lengyel, and M. E. Peter
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
Genes & Dev., April 1, 2008; 22(7): 894 - 907.
[Abstract] [Full Text] [PDF]

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 Mol Cancer ResHome page
Y. Peng, J. Laser, G. Shi, K. Mittal, J. Melamed, P. Lee, and J.-J. Wei
Antiproliferative Effects by Let-7 Repression of High-Mobility Group A2 in Uterine Leiomyoma
Mol. Cancer Res., April 1, 2008; 6(4): 663 - 673.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. S. Kumar, S. J. Erkeland, R. E. Pester, C. Y. Chen, M. S. Ebert, P. A. Sharp, and T. Jacks
Suppression of non-small cell lung tumor development by the let-7 microRNA family
PNAS, March 11, 2008; 105(10): 3903 - 3908.
[Abstract] [Full Text] [PDF]

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 CarcinogenesisHome page
D. Landi, F. Gemignani, A. Naccarati, B. Pardini, P. Vodicka, L. Vodickova, J. Novotny, A. Forsti, K. Hemminki, F. Canzian, et al.
Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
Carcinogenesis, March 1, 2008; 29(3): 579 - 584.
[Abstract] [Full Text] [PDF]

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 Mol Cancer ResHome page
K. Huppi, N. Volfovsky, T. Runfola, T. L. Jones, M. Mackiewicz, S. E. Martin, J. F. Mushinski, R. Stephens, and N. J. Caplen
The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24
Mol. Cancer Res., February 1, 2008; 6(2): 212 - 221.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
H. Yang, W. Kong, L. He, J.-J. Zhao, J. D. O'Donnell, J. Wang, R. M. Wenham, D. Coppola, P. A. Kruk, S. V. Nicosia, et al.
MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN
Cancer Res., January 15, 2008; 68(2): 425 - 433.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
J. Jiang, Y. Gusev, I. Aderca, T. A. Mettler, D. M. Nagorney, D. J. Brackett, L. R. Roberts, and T. D. Schmittgen
Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival
Clin. Cancer Res., January 15, 2008; 14(2): 419 - 427.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
Y. Guo, Z. Chen, L. Zhang, F. Zhou, S. Shi, X. Feng, B. Li, X. Meng, X. Ma, M. Luo, et al.
Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma
Cancer Res., January 1, 2008; 68(1): 26 - 33.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
J. B. Weidhaas, I. Babar, S. M. Nallur, P. Trang, S. Roush, M. Boehm, E. Gillespie, and F. J. Slack
MicroRNAs as Potential Agents to Alter Resistance to Cytotoxic Anticancer Therapy
Cancer Res., December 1, 2007; 67(23): 11111 - 11116.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
D. Ovcharenko, K. Kelnar, C. Johnson, N. Leng, and D. Brown
Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway
Cancer Res., November 15, 2007; 67(22): 10782 - 10788.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
S. U. Mertens-Talcott, S. Chintharlapalli, X. Li, and S. Safe
The Oncogenic microRNA-27a Targets Genes That Regulate Specificity Protein Transcription Factors and the G2-M Checkpoint in MDA-MB-231 Breast Cancer Cells
Cancer Res., November 15, 2007; 67(22): 11001 - 11011.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
L. Lu, D. Katsaros, I. A. Rigault de la Longrais, O. Sochirca, and H. Yu
Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis
Cancer Res., November 1, 2007; 67(21): 10117 - 10122.
[Abstract] [Full Text] [PDF]

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 BloodHome page
J.-W. Cui, Y.-J. Li, A. Sarkar, J. Brown, Y.-H. Tan, M. Premyslova, C. Michaud, N. Iscove, G.-J. Wang, and Y. Ben-David
Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation
Blood, October 1, 2007; 110(7): 2631 - 2640.
[Abstract] [Full Text] [PDF]

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 J. Mol. Diagn.Home page
M. Kruhoffer, L. Dyrskjot, T. Voss, R. L.P. Lindberg, R. Wyrich, T. Thykjaer, and T. F. Orntoft
Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube
J. Mol. Diagn., September 1, 2007; 9(4): 452 - 458.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
W. Zhang, J. E. Dahlberg, and W. Tam
MicroRNAs in Tumorigenesis: A Primer
Am. J. Pathol., September 1, 2007; 171(3): 728 - 738.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al.
The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells
Cancer Res., August 15, 2007; 67(16): 7713 - 7722.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Galardi, N. Mercatelli, E. Giorda, S. Massalini, G. V. Frajese, S. A. Ciafre, and M. G. Farace
miR-221 and miR-222 Expression Affects the Proliferation Potential of Human Prostate Carcinoma Cell Lines by Targeting p27Kip1
J. Biol. Chem., August 10, 2007; 282(32): 23716 - 23724.
[Abstract] [Full Text] [PDF]

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 Nucleic Acids ResHome page
Z. Yu, Z. Li, N. Jolicoeur, L. Zhang, Y. Fortin, E. Wang, M. Wu, and S.-H. Shen
Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers
Nucleic Acids Res., July 26, 2007; 35(13): 4535 - 4541.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. Shell, S.-M. Park, A. R. Radjabi, R. Schickel, E. O. Kistner, D. A. Jewell, C. Feig, E. Lengyel, and M. E. Peter
Let-7 expression defines two differentiation stages of cancer
PNAS, July 3, 2007; 104(27): 11400 - 11405.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
W.-O. Lui, N. Pourmand, B. K. Patterson, and A. Fire
Patterns of Known and Novel Small RNAs in Human Cervical Cancer
Cancer Res., July 1, 2007; 67(13): 6031 - 6043.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
L. Gramantieri, M. Ferracin, F. Fornari, A. Veronese, S. Sabbioni, C.-G. Liu, G. A. Calin, C. Giovannini, E. Ferrazzi, G. L. Grazi, et al.
Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma
Cancer Res., July 1, 2007; 67(13): 6092 - 6099.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
K. P. Porkka, M. J. Pfeiffer, K. K. Waltering, R. L. Vessella, T. L.J. Tammela, and T. Visakorpi
MicroRNA Expression Profiling in Prostate Cancer
Cancer Res., July 1, 2007; 67(13): 6130 - 6135.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
S. Landais, S. Landry, P. Legault, and E. Rassart
Oncogenic Potential of the miR-106-363 Cluster and Its Implication in Human T-Cell Leukemia
Cancer Res., June 15, 2007; 67(12): 5699 - 5707.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
Y. M. Shah, K. Morimura, Q. Yang, T. Tanabe, M. Takagi, and F. J. Gonzalez
Peroxisome Proliferator-Activated Receptor {alpha} Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation
Mol. Cell. Biol., June 15, 2007; 27(12): 4238 - 4247.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
M. Negrini, M. Ferracin, S. Sabbioni, and C. M. Croce
MicroRNAs in human cancer: from research to therapy
J. Cell Sci., June 1, 2007; 120(11): 1833 - 1840.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Zhu, M.-L. Si, H. Wu, and Y.-Y. Mo
MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)
J. Biol. Chem., May 11, 2007; 282(19): 14328 - 14336.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. Sevignani, G. A. Calin, S. C. Nnadi, M. Shimizu, R. V. Davuluri, T. Hyslop, P. Demant, C. M. Croce, and L. D. Siracusa
MicroRNA genes are frequently located near mouse cancer susceptibility loci
PNAS, May 8, 2007; 104(19): 8017 - 8022.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
A. R.J. Young and M. Narita
Oncogenic HMGA2: short or small?
Genes & Dev., May 1, 2007; 21(9): 1005 - 1009.
[Full Text] [PDF]


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