Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Benzeno, S.
Right arrow Articles by Friedman, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Benzeno, S.
Right arrow Articles by Friedman, S. L.
[Cancer Research 64, 3885-3891, June 1, 2004]
© 2004 American Association for Cancer Research

Regular Articles

Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1

Sharon Benzeno1, Goutham Narla1, Jorge Allina1, George Z. Cheng1, Helen L. Reeves1, Michaela S. Banck1,2, Joseph A. Odin1, J. Alan Diehl3, Doris Germain2 and Scott L. Friedman1

Divisions of 1 Liver Diseases and 2 Hematology-Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, and 3 Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania

Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well as in astrocytic gliomas. Here, we establish that KLF6 mediates growth inhibition through an interaction with cyclin D1, leading to reduced phosphorylation of the retinoblastoma protein (Rb) at Ser795. Furthermore, introduction of KLF6 disrupts cyclin D1-cyclin-dependent kinase (cdk) 4 complexes and forces the redistribution of p21Cip/Kip onto cdk2, which promotes G1 cell cycle arrest. Our data suggest that KLF6 converges with the Rb pathway to inhibit cyclin D1/cdk4 activity, resulting in growth suppression.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
A. DiFeo, L. Feld, E. Rodriguez, C. Wang, D. G. Beer, J. A. Martignetti, and G. Narla
A Functional Role for KLF6-SV1 in Lung Adenocarcinoma Prognosis and Chemotherapy Response
Cancer Res., February 15, 2008; 68(4): 965 - 970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. H. K. Wong, Y. Zhao, N. W. Schoene, C.-T. Han, R. S. M. Shih, and K. Y. Lei
Zinc deficiency depresses p21 gene expression: inhibition of cell cycle progression is independent of the decrease in p21 protein level in HepG2 cells
Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2175 - C2184.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M.-F. Tsai, C.-C. Wang, G.-C. Chang, C.-Y. Chen, H.-Y. Chen, C.-L. Cheng, Y.-P. Yang, C.-Y. Wu, F.-Y. Shih, C.-C. Liu, et al.
A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.
J Natl Cancer Inst, June 21, 2006; 98(12): 825 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. DiFeo, G. Narla, J. Hirshfeld, O. Camacho-Vanegas, J. Narla, S. L. Rose, T. Kalir, S. Yao, A. Levine, M. J. Birrer, et al.
Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination.
Clin. Cancer Res., June 15, 2006; 12(12): 3730 - 3739.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Zhu, L. Gu, H. W. Findley, C. Chen, J.-T. Dong, L. Yang, and M. Zhou
KLF5 Interacts with p53 in Regulating Survivin Expression in Acute Lymphoblastic Leukemia
J. Biol. Chem., May 26, 2006; 281(21): 14711 - 14718.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Katzenellenbogen, O. Pappo, H. Barash, N. Klopstock, L. Mizrahi, D. Olam, J. Jacob-Hirsch, N. Amariglio, G. Rechavi, L. A. Mitchell, et al.
Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the mdr2-knockout mice.
Cancer Res., April 15, 2006; 66(8): 4001 - 4010.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Hodge, E. Coghill, J. Keys, T. Maguire, B. Hartmann, A. McDowall, M. Weiss, S. Grimmond, and A. Perkins
A global role for EKLF in definitive and primitive erythropoiesis
Blood, April 15, 2006; 107(8): 3359 - 3370.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Matsumoto, A. Kubo, H. Liu, K. Akita, F. Laub, F. Ramirez, G. Keller, and S. L. Friedman
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6
Blood, February 15, 2006; 107(4): 1357 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Li, S. Yea, G. Dolios, J. A. Martignetti, G. Narla, R. Wang, M. J. Walsh, and S. L. Friedman
Regulation of Kruppel-like Factor 6 Tumor Suppressor Activity by Acetylation
Cancer Res., October 15, 2005; 65(20): 9216 - 9225.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Li, S. Yea, S. Li, Z. Chen, G. Narla, M. Banck, J. Laborda, S. Tan, J. M. Friedman, S. L. Friedman, et al.
Kruppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1
J. Biol. Chem., July 22, 2005; 280(29): 26941 - 26952.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Narla, A. DiFeo, S. Yao, A. Banno, E. Hod, H. L. Reeves, R. F. Qiao, O. Camacho-Vanegas, A. Levine, A. Kirschenbaum, et al.
Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread
Cancer Res., July 1, 2005; 65(13): 5761 - 5768.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Suzuki, K. Aizawa, T. Matsumura, and R. Nagai
Vascular Implications of the Kruppel-Like Family of Transcription Factors
Arterioscler. Thromb. Vasc. Biol., June 1, 2005; 25(6): 1135 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Ding, J. R. Grammer, M. A. Nelson, J.-L. Guan, J. E. Stewart Jr., and C. L. Gladson
p27Kip1 and Cyclin D1 Are Necessary for Focal Adhesion Kinase Regulation of Cell Cycle Progression in Glioblastoma Cells Propagated in Vitro and in Vivo in the Scid Mouse Brain
J. Biol. Chem., February 25, 2005; 280(8): 6802 - 6815.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Narla, A. DiFeo, H. L. Reeves, D. J. Schaid, J. Hirshfeld, E. Hod, A. Katz, W. B. Isaacs, S. Hebbring, A. Komiya, et al.
A Germline DNA Polymorphism Enhances Alternative Splicing of the KLF6 Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk
Cancer Res., February 15, 2005; 65(4): 1213 - 1222.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.