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[Cancer Research 64, 4302-4308, June 15, 2004]
© 2004 American Association for Cancer Research

Regular Articles

Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4

Zhongxing Liang1, Tao Wu1, Hong Lou1, Xiwen Yu1, Russell S. Taichman4, Stephen K. Lau1, Shuming Nie2, Jay Umbreit1 and Hyunsuk Shim1,3

1 Department of Hematology/Oncology, Winship Cancer Institute, Atlanta, Georgia; Departments of 2 Biomedical Engineering and 3 Radiology, Emory University, Atlanta, Georgia; and 4 Department of Periodontics, Prevention, and Geriatrics, University of Michigan, Ann Arbor, Michigan

Metastasis shares many similarities with leukocyte trafficking. Among those chemokine receptors thought to be involved in hemopoietic cell homing, stromal cell-derived factor-1 and its receptor CXC chemokine receptor-4 (CXCR4) have received considerable attention. Like hemopoietic cell homing, levels of stromal cell-derived factor-1 are high at sites of breast cancer metastasis including lymph node, lung, liver, and the marrow. Moreover, CXCR4 expression is low in normal breast tissues and high in malignant tumors, suggesting that a blockade of CXCR4 might limit tumor metastasis. We therefore investigated the role of a synthetic antagonist 14-mer peptide (TN14003) in inhibiting metastasis in an animal model. Not only was TN14003 effective in limiting metastasis of breast cancer by inhibiting migration, but it may also prove useful as a diagnostic tool to identify CXCR4 receptor-positive tumor cells in culture and tumors in paraffin-embedded clinical samples.




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Copyright © 2004 by the American Association for Cancer Research.