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[Cancer Research 64, 6368-6371, September 15, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Human In vivo Radiation-Induced Biomarkers

Gene Expression Changes in Radiotherapy Patients

Sally A. Amundson1, Marcy B. Grace2, Christopher B. McLeland2, Michael W. Epperly3, Andrew Yeager3, Qimin Zhan3, Joel S. Greenberger3 and Albert J. Fornace, Jr.1

1 Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; 2 Biological Dosimetry Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland; and 3 University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiments. Additional studies may reveal correlations between responses and either diagnosis or prognosis, and such in vivo validation marks an important step in the development of potentially informative radiation exposure biomarkers.




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