This Article Full Text Full Text (PDF) Supplementary Data Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wiemels, J. L. Articles by Wrensch, M. Search for Related Content PubMed PubMed Citation Articles by Wiemels, J. L. Articles by Wrensch, M.

Reduced Immunoglobulin E and Allergy among Adults with Glioma Compared with Controls

¹ Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, ² Department of Neurological Surgery, and ³ Comprehensive Cancer Center, University of California San Francisco, San Francisco, California; and ⁴ Department of Neurology, Wayne State University, Detroit, Michigan

We and others have reported previously that adults with glioma are 1.5- to 4-fold less likely than controls to report a variety of allergic conditions. The consistent nature of this relationship calls for a biological explanation so that preventative or therapeutic modalities can be explored. We enrolled 403 newly diagnosed adult glioma cases in the San Francisco Bay Area over a 3-year period using a population-based cancer registry and 402 age/gender/ethnicity frequency-matched controls identified via random digit dialing. We assessed total, food-specific, and respiratory-specific IgE in available case (n = 228) and control (n = 289) serum samples. IgE levels were associated with gender, age, smoking status, and ethnicity among cases and/or controls. Among the cases, IgE levels were not associated with aspects of glioma therapy including radiation, chemotherapy, or tumor resection. Total IgE levels were lower in cases than controls: age/gender/ethnicity/education/smoking-adjusted odds ratio (OR) for elevated versus normal total IgE was 0.37 [95% confidence interval (CI), 0.22–0.64]. For the food panel, OR was 0.12 (95% CI, 0.04–0.41). For the respiratory panel, OR was 0.76 (95% CI, 0.52–1.1). Among respiratory allergies, late age of onset (>12 years) but not IgE levels defined a group with strong associations with risk (OR, 0.50; 95% CI, 0.33–0.75). These results corroborate and strengthen our findings of an inverse association between allergic reactions and glioma by showing a relationship with a biomarker for allergy and cancer for the first time. Furthermore, the results indicate a complex relationship between allergic disease and glioma risk that varies by allergen and allergic pathology.

This article has been cited by other articles:

				A. M. Ruder, T. Carreon, M. A. Butler, G. M. Calvert, K. E. Davis-King, M. A. Waters, P. A. Schulte, J. S. Mandel, R. F. Morton, D. J. Reding, et al. Exposure to Farm Crops, Livestock, and Farm Tasks and Risk of Glioma: The Upper Midwest Health Study Am. J. Epidemiol., June 15, 2009; 169(12): 1479 - 1491. [Abstract] [Full Text] [PDF]

				P. Rajaraman, A. V. Brenner, M. A. Butler, S. S. Wang, R. M. Pfeiffer, A. M. Ruder, M. S. Linet, M. Yeager, Z. Wang, N. Orr, et al. Common Variation in Genes Related to Innate Immunity and Risk of Adult Glioma Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1651 - 1658. [Abstract] [Full Text] [PDF]

				M. E. Scheurer, R. El-Zein, P. A. Thompson, K. D. Aldape, V. A. Levin, M. R. Gilbert, J. S. Weinberg, and M. L. Bondy Long-term Anti-inflammatory and Antihistamine Medication Use and Adult Glioma Risk Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1277 - 1281. [Abstract] [Full Text] [PDF]

				A.V. Brenner, M.A. Butler, S.S. Wang, A.M. Ruder, N. Rothman, P.A. Schulte, S.J. Chanock, H.A. Fine, M.S. Linet, and P.D. Inskip Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma Carcinogenesis, December 1, 2007; 28(12): 2543 - 2547. [Abstract] [Full Text] [PDF]

				A. E. Prizment, A. R. Folsom, J. R. Cerhan, A. Flood, J. A. Ross, and K. E. Anderson History of Allergy and Reduced Incidence of Colorectal Cancer, Iowa Women's Health Study Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2357 - 2362. [Abstract] [Full Text] [PDF]

				J. A. Schwartzbaum, A. Ahlbom, S. Lonn, B. Malmer, A. Wigertz, A. Auvinen, A. J. Brookes, H. Collatz Christensen, R. Henriksson, C. Johansen, et al. An International Case-Control Study of Interleukin-4R{alpha}, Interleukin-13, and Cyclooxygenase-2 Polymorphisms and Glioblastoma Risk Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2448 - 2454. [Abstract] [Full Text] [PDF]

				E. Linos, T. Raine, A. Alonso, and D. Michaud Atopy and Risk of Brain Tumors: A Meta-analysis J Natl Cancer Inst, October 17, 2007; 99(20): 1544 - 1550. [Abstract] [Full Text] [PDF]

				A. Wigertz, S. Lonn, J. Schwartzbaum, P. Hall, A. Auvinen, H. C. Christensen, C. Johansen, L. Klaeboe, T. Salminen, M. J. Schoemaker, et al. Allergic Conditions and Brain Tumor Risk Am. J. Epidemiol., October 15, 2007; 166(8): 941 - 950. [Abstract] [Full Text] [PDF]

				G. M. E. Matta, S. Battaglio, C. DiBello, P. Napoli, C. Baldi, G. Ciccone, M. Coscia, M. Boccadoro, and M. Massaia Polyclonal Immunoglobulin E Levels Are Correlated with Hemoglobin Values and Overall Survival in Patients with Multiple Myeloma Clin. Cancer Res., September 15, 2007; 13(18): 5348 - 5354. [Abstract] [Full Text] [PDF]

				S. N. Karagiannis, M. G. Bracher, J. Hunt, N. McCloskey, R. L. Beavil, A. J. Beavil, D. J. Fear, R. G. Thompson, N. East, F. Burke, et al. IgE-Antibody-Dependent Immunotherapy of Solid Tumors: Cytotoxic and Phagocytic Mechanisms of Eradication of Ovarian Cancer Cells J. Immunol., September 1, 2007; 179(5): 2832 - 2843. [Abstract] [Full Text] [PDF]

				J. L. Wiemels, J. K. Wiencke, K. T. Kelsey, M. Moghadassi, T. Rice, K. Y. Urayama, R. Miike, and M. Wrensch Allergy-Related Polymorphisms Influence Glioma Status and Serum IgE Levels Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1229 - 1235. [Abstract] [Full Text] [PDF]

				M. Wrensch, J. K. Wiencke, J. Wiemels, R. Miike, J. Patoka, M. Moghadassi, A. McMillan, K. T. Kelsey, K. Aldape, K. R. Lamborn, et al. Serum IgE, Tumor Epidermal Growth Factor Receptor Expression, and Inherited Polymorphisms Associated with Glioma Survival. Cancer Res., April 15, 2006; 66(8): 4531 - 4541. [Abstract] [Full Text] [PDF]

				J. Schwartzbaum, A. Ahlbom, B. Malmer, S. Lonn, A. J. Brookes, H. Doss, W. Debinski, R. Henriksson, and M. Feychting Polymorphisms Associated with Asthma Are Inversely Related to Glioblastoma Multiforme Cancer Res., July 15, 2005; 65(14): 6459 - 6465. [Abstract] [Full Text] [PDF]

				M. Wrensch, A. Weinberg, J. Wiencke, R. Miike, J. Sison, J. Wiemels, G. Barger, G. DeLorenze, K. Aldape, and K. Kelsey History of Chickenpox and Shingles and Prevalence of Antibodies to Varicella-Zoster Virus and Three Other Herpesviruses among Adults with Glioma and Controls Am. J. Epidemiol., May 15, 2005; 161(10): 929 - 938. [Abstract] [Full Text] [PDF]