Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eckfeld, K.
Right arrow Articles by Clark, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eckfeld, K.
Right arrow Articles by Clark, G. J.
[Cancer Research 64, 8688-8693, December 1, 2004]
© 2004 American Association for Cancer Research

Regular Articles

RASSF4/AD037 Is a Potential Ras Effector/Tumor Suppressor of the RASSF Family

Kristin Eckfeld1, Luke Hesson2, Michele D. Vos1, Ivan Bieche3, Farida Latif2 and Geoffrey J. Clark1

1 Department of Cell and Cancer Biology, National Cancer Institute, Rockville, Maryland; 2 Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham, United Kingdom; and 3 Laboratoire d’Oncogenetique-INSERM E0017, Centre Rene Huguenin, St-Cloud, France

Activated Ras proteins interact with a broad range of effector proteins to induce a diverse series of biological consequences. Although typically associated with enhanced growth and transformation, activated Ras may also induce growth antagonistic effects such as senescence or apoptosis. It is now apparent that some of the growth-inhibitory properties of Ras are mediated via the RASSF family of Ras effector/tumor suppressors. To date, four members of this family have been identified (Nore1, RASSF1, RASSF2, and RASSF3). We now identify a fifth member of this group, RASSF4 (AD037). RASSF4 shows approximately 25% identity with RASSF1A and 60% identity with RASSF2. RASSF4 binds directly to activated K-Ras in a GTP-dependent manner via the effector domain, thus exhibiting the basic properties of a Ras effector. Overexpression of RASSF4 induces Ras-dependent apoptosis in 293-T cells and inhibits the growth of human tumor cell lines. Although broadly expressed in normal tissue, RASSF4 is frequently down-regulated by promoter methylation in human tumor cells. Thus, RASSF4 appears to be a new member of the RASSF family of potential Ras effector/tumor suppressors.




This article has been cited by other articles:


Home page
 Mol. Biol. CellHome page
V. Sherwood, R. Manbodh, C. Sheppard, and A. D. Chalmers
RASSF7 Is a Member of a New Family of RAS Association Domain-containing Proteins and Is Required for Completing Mitosis
Mol. Biol. Cell, April 1, 2008; 19(4): 1772 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Hao, A. Chun, K. Cheung, B. Rashidi, and X. Yang
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
J. Biol. Chem., February 29, 2008; 283(9): 5496 - 5509.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Milstein, C. K. Mooser, H. Hu, M. Fejzo, D. Slamon, L. Goodglick, S. Dry, and J. Colicelli
RIN1 Is a Breast Tumor Suppressor Gene
Cancer Res., December 15, 2007; 67(24): 11510 - 11516.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. Donninger, M. D. Vos, and G. J. Clark
The RASSF1A tumor suppressor
J. Cell Sci., September 15, 2007; 120(18): 3163 - 3172.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Xia, L. W. Forman, and D. V. Faller
Protein Kinase C{delta} Is Required for Survival of Cells Expressing Activated p21RAS
J. Biol. Chem., May 4, 2007; 282(18): 13199 - 13210.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Moshnikova, J. Frye, J. W. Shay, J. D. Minna, and A. V. Khokhlatchev
The Growth and Tumor Suppressor NORE1A Is a Cytoskeletal Protein That Suppresses Growth by Inhibition of the ERK Pathway
J. Biol. Chem., March 24, 2006; 281(12): 8143 - 8152.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Vos, A. Dallol, K. Eckfeld, N. P. C. Allen, H. Donninger, L. B. Hesson, D. Calvisi, F. Latif, and G. J. Clark
The RASSF1A Tumor Suppressor Activates Bax via MOAP-1
J. Biol. Chem., February 24, 2006; 281(8): 4557 - 4563.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. David, S.-Y. Sun, E. K. Waller, J. Chen, F. R. Khuri, and S. Lonial
The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT
Blood, December 15, 2005; 106(13): 4322 - 4329.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Agathanggelou, W. N. Cooper, and F. Latif
Role of the Ras-Association Domain Family 1 Tumor Suppressor Gene in Human Cancers
Cancer Res., May 1, 2005; 65(9): 3497 - 3508.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2004 by the American Association for Cancer Research.