Cancer Research Annual Meeting 2010 Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hickson, I.
Right arrow Articles by Smith, G. C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hickson, I.
Right arrow Articles by Smith, G. C. M.
[Cancer Research 64, 9152-9159, December 15, 2004]
© 2004 American Association for Cancer Research

Regular Articles

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

Ian Hickson1, Yan Zhao2, Caroline J. Richardson1, Sharon J. Green1, Niall M. B. Martin1, Alisdair I. Orr1, Philip M. Reaper3, Stephen P. Jackson3, Nicola J. Curtin2 and Graeme C. M. Smith1

1 KuDOS Pharmaceuticals Ltd., Cambridge Science Park, Milton Road, Cambridge; 2 Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne; and 3 Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Zoology, Cambridge University, Cambridge, United Kingdom

The serine/threonine protein kinase ATM signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NBS1, and BRCA1. Mutation of ATM occurs in the human autosomal recessive disorder ataxia-telangiectasia, which is characterized by hypersensitivity to ionizing radiation and a failure of cells to arrest the cell cycle after the induction of DNA double-strand breaks. It has thus been proposed that ATM inhibition would cause cellular radio- and chemosensitization. Through screening a small molecule compound library developed for the phosphatidylinositol 3'-kinase–like kinase family, we identified an ATP-competitive inhibitor, 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (KU-55933), that inhibits ATM with an IC50 of 13 nmol/L and a Ki of 2.2 nmol/L. KU-55933 shows specificity with respect to inhibition of other phosphatidylinositol 3'-kinase–like kinases. Cellular inhibition of ATM by KU-55933 was demonstrated by the ablation of ionizing radiation-dependent phosphorylation of a range of ATM targets, including p53, {gamma}H2AX, NBS1, and SMC1. KU-55933 did not show inhibition of UV light DNA damage induced cellular phosphorylation events. Exposure of cells to KU-55933 resulted in a significant sensitization to the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin. Inhibition of ATM by KU-55933 also caused a loss of ionizing radiation-induced cell cycle arrest. By contrast, KU-55933 did not potentiate the cytotoxic effects of ionizing radiation on ataxia-telangiectasia cells, nor did it affect their cell cycle profile after DNA damage. We conclude that KU-55933 is a novel, specific, and potent inhibitor of the ATM kinase.




This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
C. Bauerschmidt, C. Arrichiello, S. Burdak-Rothkamm, M. Woodcock, M. A. Hill, D. L. Stevens, and K. Rothkamm
Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin
Nucleic Acids Res., November 11, 2009; (2009) gkp976v1.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. E. Bansbach, R. Betous, C. A. Lovejoy, G. G. Glick, and D. Cortez
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
Genes & Dev., October 15, 2009; 23(20): 2405 - 2414.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Bolderson, D. J. Richard, B.-B. S. Zhou, and K. K. Khanna
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
Clin. Cancer Res., October 15, 2009; 15(20): 6314 - 6320.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. Stephan, C. Concannon, E. Kremmer, M. P. Carty, and H.-P. Nasheuer
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis
Nucleic Acids Res., October 1, 2009; 37(18): 6028 - 6041.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. K. Freschauf, F. Karimi-Busheri, A. Ulaczyk-Lesanko, T. R. Mereniuk, A. Ahrens, J. M. Koshy, A. Rasouli-Nia, P. Pasarj, C. F.B. Holmes, F. Rininsland, et al.
Identification of a Small Molecule Inhibitor of the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase
Cancer Res., October 1, 2009; 69(19): 7739 - 7746.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. E. Golding, E. Rosenberg, N. Valerie, I. Hussaini, M. Frigerio, X. F. Cockcroft, W. Y. Chong, M. Hummersone, L. Rigoreau, K. A. Menear, et al.
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Mol. Cancer Ther., October 1, 2009; 8(10): 2894 - 2902.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C.-H. Lim, S.-W. Chong, and Y.-J. Jiang
Udu Deficiency Activates DNA Damage Checkpoint
Mol. Biol. Cell, October 1, 2009; 20(19): 4183 - 4193.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Sobeck, S. Stone, I. Landais, B. de Graaf, and M. E. Hoatlin
The Fanconi Anemia Protein FANCM Is Controlled by FANCD2 and the ATR/ATM Pathways
J. Biol. Chem., September 18, 2009; 284(38): 25560 - 25568.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
V. Lafarga, A. Cuadrado, I. Lopez de Silanes, R. Bengoechea, O. Fernandez-Capetillo, and A. R. Nebreda
p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint
Mol. Cell. Biol., August 15, 2009; 29(16): 4341 - 4351.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. Jiang, H. C. Reinhardt, J. Bartkova, J. Tommiska, C. Blomqvist, H. Nevanlinna, J. Bartek, M. B. Yaffe, and M. T. Hemann
The combined status of ATM and p53 link tumor development with therapeutic response
Genes & Dev., August 15, 2009; 23(16): 1895 - 1909.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-W. Zhang, T. L. Jones, S. E. Martin, N. J. Caplen, and Y. Pommier
Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response
J. Biol. Chem., July 3, 2009; 284(27): 18085 - 18095.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Kumari, V. Somma, A. J. Nakamura, W. M. Bonner, E. D'Ambrosio, and K. Usdin
The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome
Nucleic Acids Res., July 1, 2009; 37(13): 4385 - 4392.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. J. Martin, Z. Liu, J. Pipino, B. Chestnut, and M. A. Landek
Molecular Regulation of DNA Damage-Induced Apoptosis in Neurons of Cerebral Cortex
Cereb Cortex, June 1, 2009; 19(6): 1273 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C.-Y. Tsai, A. S. Ray, D. B. Tumas, M. J. Keating, H. Reiser, and W. Plunkett
Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219
Clin. Cancer Res., June 1, 2009; 15(11): 3760 - 3769.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Stuart and J. Y. J. Wang
Ionizing Radiation Induces ATM-independent Degradation of p21Cip1 in Transformed Cells
J. Biol. Chem., May 29, 2009; 284(22): 15061 - 15070.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Badie, C. Liao, M. Thanasoula, P. Barber, M. A. Hill, and M. Tarsounas
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation
J. Cell Biol., May 18, 2009; 185(4): 587 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
I. R. Powley, A. Kondrashov, L. A. Young, H. C. Dobbyn, K. Hill, I. G. Cannell, M. Stoneley, Y.-W. Kong, J. A. Cotes, G. C.M. Smith, et al.
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes
Genes & Dev., May 15, 2009; 23(10): 1207 - 1220.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. N. Ivanov, H. Zhou, M. A. Partridge, and T. K. Hei
Inhibition of Ataxia Telangiectasia Mutated Kinase Activity Enhances TRAIL-Mediated Apoptosis in Human Melanoma Cells
Cancer Res., April 15, 2009; 69(8): 3510 - 3519.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Sak, S. Grehl, M. Engelhard, A. Wierlemann, H.-P. Kaelberlah, P. Erichsen, C. Pottgen, M. Groneberg, and M. Stuschke
Long-Term In vivo Effects of Cisplatin on {gamma}-H2AX Foci Signaling in Peripheral Lymphocytes of Tumor Patients After Irradiation
Clin. Cancer Res., April 15, 2009; 15(8): 2927 - 2934.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Soriani, A. Zingoni, C. Cerboni, M. L. Iannitto, M. R. Ricciardi, V. Di Gialleonardo, M. Cippitelli, C. Fionda, M. T. Petrucci, A. Guarini, et al.
ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
Blood, April 9, 2009; 113(15): 3503 - 3511.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
A. Kotnis, L. Du, C. Liu, S. W Popov, and Q. Pan-Hammarstrom
Non-homologous end joining in class switch recombination: the beginning of the end
Phil Trans R Soc B, March 12, 2009; 364(1517): 653 - 665.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Chanoux, B. Yin, K. A. Urtishak, A. Asare, C. H. Bassing, and E. J. Brown
ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress
J. Biol. Chem., February 27, 2009; 284(9): 5994 - 6003.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Solier, O. Sordet, K. W. Kohn, and Y. Pommier
Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways
Mol. Cell. Biol., January 1, 2009; 29(1): 68 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Hingorani, C. L. White, A. Merron, I. Peerlinck, M. E. Gore, A. Slade, S. D. Scott, C. M. Nutting, H. S. Pandha, A. A. Melcher, et al.
Inhibition of Repair of Radiation-Induced DNA Damage Enhances Gene Expression from Replication-Defective Adenoviral Vectors
Cancer Res., December 1, 2008; 68(23): 9771 - 9778.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. L. Medhurst, D. O. Warmerdam, I. Akerman, E. H. Verwayen, R. Kanaar, V. A. J. Smits, and N. D. Lakin
ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage
J. Cell Sci., December 1, 2008; 121(23): 3933 - 3940.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Blickwedehl, M. Agarwal, C. Seong, R. K. Pandita, T. Melendy, P. Sung, T. K. Pandita, and N. Bangia
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability
PNAS, October 21, 2008; 105(42): 16165 - 16170.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Kinner, W. Wu, C. Staudt, and G. Iliakis
{gamma}-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
Nucleic Acids Res., October 1, 2008; 36(17): 5678 - 5694.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. D. Rainey, M. E. Charlton, R. V. Stanton, and M. B. Kastan
Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation
Cancer Res., September 15, 2008; 68(18): 7466 - 7474.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Burdak-Rothkamm, K. Rothkamm, and K. M. Prise
ATM Acts Downstream of ATR in the DNA Damage Response Signaling of Bystander Cells
Cancer Res., September 1, 2008; 68(17): 7059 - 7065.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. Valli, G. Paroni, A. M. Di Francesco, R. Riccardi, M. Tavecchio, E. Erba, A. Boldetti, M. Gianni', M. Fratelli, C. Pisano, et al.
Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity
Mol. Cancer Ther., September 1, 2008; 7(9): 2941 - 2954.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Guirouilh-Barbat, C. Redon, and Y. Pommier
Transcription-coupled DNA Double-Strand Breaks Are Mediated via the Nucleotide Excision Repair and the Mre11-Rad50-Nbs1 Complex
Mol. Biol. Cell, September 1, 2008; 19(9): 3969 - 3981.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. A. Stohr and E. H. Blackburn
ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells
Cancer Res., July 1, 2008; 68(13): 5309 - 5317.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
T. T. Koll, S. S. Feis, M. H. Wright, M. M. Teniola, M. M. Richardson, A. I. Robles, J. Bradsher, J. Capala, and L. Varticovski
HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair
Mol. Cancer Ther., July 1, 2008; 7(7): 1985 - 1992.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
E. Soutoglou and T. Misteli
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
Science, June 13, 2008; 320(5882): 1507 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
X. Zhao, R. J. Madden-Fuentes, B. X. Lou, J. M. Pipas, J. Gerhardt, C. J. Rigell, and E. Fanning
Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells
J. Virol., June 1, 2008; 82(11): 5316 - 5328.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Yamaguchi, N. Fujimori-Tonou, Y. Yoshimura, T. Kishi, H. Okamoto, and I. Masai
Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53
Development, April 1, 2008; 135(7): 1247 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Crescenzi, G. Palumbo, J. de Boer, and H. J.M. Brady
Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy
Clin. Cancer Res., March 15, 2008; 14(6): 1877 - 1887.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. El-Shemerly, D. Hess, A. K. Pyakurel, S. Moselhy, and S. Ferrari
ATR-dependent pathways control hEXO1 stability in response to stalled forks
Nucleic Acids Res., February 2, 2008; 36(2): 511 - 519.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Stagni, M. G. di Bari, S. Cursi, I. Condo, M. T. Cencioni, R. Testi, Y. Lerenthal, E. Cundari, and D. Barila
ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells
Blood, January 15, 2008; 111(2): 829 - 837.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. P. Shouse, X. Cai, and X. Liu
Serine 15 Phosphorylation of p53 Directs Its Interaction with B56{gamma} and the Tumor Suppressor Activity of B56{gamma}-Specific Protein Phosphatase 2A
Mol. Cell. Biol., January 1, 2008; 28(1): 448 - 456.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
N. K. Kolas, J. R. Chapman, S. Nakada, J. Ylanko, R. Chahwan, F. D. Sweeney, S. Panier, M. Mendez, J. Wildenhain, T. M. Thomson, et al.
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
Science, December 7, 2007; 318(5856): 1637 - 1640.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
B. A. Olofsson, C. M. Kelly, J. Kim, S. M. Hornsby, and J. Azizkhan-Clifford
Phosphorylation of Sp1 in Response to DNA Damage by Ataxia Telangiectasia-Mutated Kinase
Mol. Cancer Res., December 1, 2007; 5(12): 1319 - 1330.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. W. Verschuren, K. H. Ban, M. A. Masek, N. L. Lehman, and P. K. Jackson
Loss of Emi1-Dependent Anaphase-Promoting Complex/Cyclosome Inhibition Deregulates E2F Target Expression and Elicits DNA Damage-Induced Senescence
Mol. Cell. Biol., November 15, 2007; 27(22): 7955 - 7965.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. J. Chen and C. S. Nirodi
The Epidermal Growth Factor Receptor: A Role in Repair of Radiation-Induced DNA Damage
Clin. Cancer Res., November 15, 2007; 13(22): 6555 - 6560.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. E. Lally, G. A. Geiger, S. Kridel, A. E. Arcury-Quandt, M. E. Robbins, N. D. Kock, K. Wheeler, P. Peddi, A. Georgakilas, G. D. Kao, et al.
Identification and Biological Evaluation of a Novel and Potent Small Molecule Radiation Sensitizer via an Unbiased Screen of a Chemical Library
Cancer Res., September 15, 2007; 67(18): 8791 - 8799.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
I. M. Munoz, P. A. Jowsey, R. Toth, and J. Rouse
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage
Nucleic Acids Res., August 13, 2007; 35(16): 5312 - 5322.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. J. Cariveau, X. Tang, X.-L. Cui, and B. Xu
Characterization of an NBS1 C-Terminal Peptide That Can Inhibit Ataxia Telangiectasia Mutated (ATM)-Mediated DNA Damage Responses and Enhance Radiosensitivity
Mol. Pharmacol., August 1, 2007; 72(2): 320 - 326.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. S. Bentle, K. E. Reinicke, Y. Dong, E. A. Bey, and D. A. Boothman
Nonhomologous End Joining Is Essential for Cellular Resistance to the Novel Antitumor Agent, {beta}-Lapachone
Cancer Res., July 15, 2007; 67(14): 6936 - 6945.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Cerboni, A. Zingoni, M. Cippitelli, M. Piccoli, L. Frati, and A. Santoni
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
Blood, July 15, 2007; 110(2): 606 - 615.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-C. Tsai, H. Qi, and L. F. Liu
Protection of DNA Ends by Telomeric 3' G-Tail Sequences
J. Biol. Chem., June 29, 2007; 282(26): 18786 - 18792.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L. F. Povirk, R.-Z. Zhou, D. A. Ramsden, S. P. Lees-Miller, and K. Valerie
Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
Nucleic Acids Res., June 9, 2007; 35(12): 3869 - 3878.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
T. Kiziltepe, T. Hideshima, L. Catley, N. Raje, H. Yasui, N. Shiraishi, Y. Okawa, H. Ikeda, S. Vallet, S. Pozzi, et al.
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells
Mol. Cancer Ther., June 1, 2007; 6(6): 1718 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. D. Fernandes, Y. Sun, and B. D. Price
Activation of the Kinase Activity of ATM by Retinoic Acid Is Required for CREB-dependent Differentiation of Neuroblastoma Cells
J. Biol. Chem., June 1, 2007; 282(22): 16577 - 16584.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Difilippantonio, A. Celeste, M. J. Kruhlak, Y. Lee, M. J. Difilippantonio, L. Feigenbaum, S. P. Jackson, P. J. McKinnon, and A. Nussenzweig
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
J. Exp. Med., May 14, 2007; 204(5): 1003 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. L. Ball, M. R. Ehrhardt, D. A. Mordes, G. G. Glick, W. J. Chazin, and D. Cortez
Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins
Mol. Cell. Biol., May 1, 2007; 27(9): 3367 - 3377.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. A. MacDougall, T. S. Byun, C. Van, M.-c. Yee, and K. A. Cimprich
The structural determinants of checkpoint activation
Genes & Dev., April 15, 2007; 21(8): 898 - 903.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Bagley, G. Singh, and J. Iacomini
Regulation of Oxidative Stress Responses by Ataxia-Telangiectasia Mutated Is Required for T Cell Proliferation
J. Immunol., April 15, 2007; 178(8): 4757 - 4763.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Tomimatsu, C. G. T. Tahimic, A. Otsuki, S. Burma, A. Fukuhara, K. Sato, G. Shiota, M. Oshimura, D. J. Chen, and A. Kurimasa
Ku70/80 Modulates ATM and ATR Signaling Pathways in Response to DNA Double Strand Breaks
J. Biol. Chem., April 6, 2007; 282(14): 10138 - 10145.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Shi, G. E. Dodson, P. S. Mukhopadhyay, N. P. Shanware, A. T. Trinh, and R. S. Tibbetts
Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies
J. Biol. Chem., March 23, 2007; 282(12): 9236 - 9243.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
D. Deckbar, J. Birraux, A. Krempler, L. Tchouandong, A. Beucher, S. Walker, T. Stiff, P. Jeggo, and M. Lobrich
Chromosome breakage after G2 checkpoint release
J. Cell Biol., March 12, 2007; 176(6): 749 - 755.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Gabrielli, Y. Q. Chau, N. Giles, A. Harding, F. Stevens, and H. Beamish
Caffeine Promotes Apoptosis in Mitotic Spindle Checkpoint-arrested Cells
J. Biol. Chem., March 9, 2007; 282(10): 6954 - 6964.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. P. C. Chen, N. Uematsu, J. Kobayashi, Y. Lerenthal, A. Krempler, H. Yajima, M. Lobrich, Y. Shiloh, and D. J. Chen
Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break
J. Biol. Chem., March 2, 2007; 282(9): 6582 - 6587.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. P. Shanware, A. T. Trinh, L. M. Williams, and R. S. Tibbetts
Coregulated Ataxia Telangiectasia-mutated and Casein Kinase Sites Modulate cAMP-response Element-binding Protein-Coactivator Interactions in Response to DNA Damage
J. Biol. Chem., March 2, 2007; 282(9): 6283 - 6291.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. Valerie, A. Yacoub, M. P. Hagan, D. T. Curiel, P. B. Fisher, S. Grant, and P. Dent
Radiation-induced cell signaling: inside-out and outside-in
Mol. Cancer Ther., March 1, 2007; 6(3): 789 - 801.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
L. Carlessi, G. Buscemi, G. Larson, Z. Hong, J. Z. Wu, and D. Delia
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2
Mol. Cancer Ther., March 1, 2007; 6(3): 935 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. E. Golding, E. Rosenberg, S. Neill, P. Dent, L. F. Povirk, and K. Valerie
Extracellular Signal-Related Kinase Positively Regulates Ataxia Telangiectasia Mutated, Homologous Recombination Repair, and the DNA Damage Response
Cancer Res., February 1, 2007; 67(3): 1046 - 1053.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Pereg, S. Lam, A. Teunisse, S. Biton, E. Meulmeester, L. Mittelman, G. Buscemi, K. Okamoto, Y. Taya, Y. Shiloh, et al.
Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage.
Mol. Cell. Biol., September 1, 2006; 26(18): 6819 - 6831.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. McCabe, N. C. Turner, C. J. Lord, K. Kluzek, A. Bialkowska, S. Swift, S. Giavara, M. J. O'Connor, A. N. Tutt, M. Z. Zdzienicka, et al.
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Cancer Res., August 15, 2006; 66(16): 8109 - 8115.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. J. Deans, K. K. Khanna, C. J. McNees, C. Mercurio, J. Heierhorst, and G. A. McArthur
Cyclin-Dependent Kinase 2 Functions in Normal DNA Repair and Is a Therapeutic Target in BRCA1-Deficient Cancers
Cancer Res., August 15, 2006; 66(16): 8219 - 8226.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. J. Lord, M. D. Garrett, and A. Ashworth
Targeting the Double-Strand DNA Break Repair Pathway as a Therapeutic Strategy
Clin. Cancer Res., August 1, 2006; 12(15): 4463 - 4468.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Biton, I. Dar, L. Mittelman, Y. Pereg, A. Barzilai, and Y. Shiloh
Nuclear Ataxia-Telangiectasia Mutated (ATM) Mediates the Cellular Response to DNA Double Strand Breaks in Human Neuron-like Cells
J. Biol. Chem., June 23, 2006; 281(25): 17482 - 17491.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Zhao, H. D. Thomas, M. A. Batey, I. G. Cowell, C. J. Richardson, R. J. Griffin, A. H. Calvert, D. R. Newell, G. C.M. Smith, and N. J. Curtin
Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441.
Cancer Res., May 15, 2006; 66(10): 5354 - 5362.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. E. Bryant and T. Helleday
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
Nucleic Acids Res., March 23, 2006; 34(6): 1685 - 1691.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
N. Levy, A. Martz, A. Bresson, C. Spenlehauer, G. de Murcia, and J. Menissier-de Murcia
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage
Nucleic Acids Res., January 5, 2006; 34(1): 32 - 41.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Pereg, D. Shkedy, P. de Graaf, E. Meulmeester, M. Edelson-Averbukh, M. Salek, S. Biton, A. F. A. S. Teunisse, W. D. Lehmann, A. G. Jochemsen, et al.
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
PNAS, April 5, 2005; 102(14): 5056 - 5061.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.