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3(VI)
1 Program in Human Genetics and Molecular Biology and the Sidney Kimmel Comprehensive Cancer Center and 2 Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland; 3 Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; 4 Imgenex Corp., San Diego, California; and 5 Tumor Angiogenesis Section, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, Maryland
Tumor endothelial marker (TEM)8 was uncovered as a gene expressed predominantly in tumor endothelium, and its protein product was recently identified as the receptor for anthrax toxin. Here, we demonstrate that TEM8 protein is preferentially expressed in endothelial cells of neoplastic tissue. We used the extracellular domain of TEM8 to search for ligands and identified the 
3 subunit of collagen VI as an interacting partner. The TEM8-interacting region on collagen 3(VI) was mapped to its COOH-terminal C5 domain. Remarkably, collagen 3(VI) is also preferentially expressed in tumor endothelium in a pattern concordant with that of TEM8. These results suggest that the TEM8/C5 interaction may play an important biological role in tumor angiogenesis.
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