Cancer Research Cell Death Mechanisms and Cancer Therapy Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Szabo, C. I.
Right arrow Articles by Meijers-Heijboer, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Szabo, C. I.
Right arrow Articles by Meijers-Heijboer, H.
[Cancer Research 64, 840-843, February 1, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Are ATM Mutations 7271T->G and IVS10-6T->G Really High-Risk Breast Cancer-Susceptibility Alleles?

Csilla I. Szabo1, Mieke Schutte2, Annegien Broeks3, Jeanine J. Houwing-Duistermaat2, Yvonne R. Thorstenson4, Francine Durocher5, Rogier A. Oldenburg2,6, Marijke Wasielewski2, Fabrice Odefrey1, Deborah Thompson1, Arno N. Floore3, Jaennelle Kraan6, Jan G. M. Klijn2, Ans M. W. van den Ouweland2 the BRCA-X Consortium8 Cooperative Family Registry Breast Cancer Study8 Interdisciplinary Health Research International Team on Breast Cancer Susceptibility8, Teresa M. U. Wagner7, Peter Devilee6, Jacques Simard5, Laura J. van ‘t Veer3, David E. Goldgar1 and Hanne Meijers-Heijboer2

1 International Agency for Research on Cancer, Lyon, France; 2 Erasmus University Medical Center, Rotterdam, the Netherlands; 3 The Netherlands Cancer Institute, Amsterdam, the Netherlands; 4 Stanford Genome Technology Center, Palo Alto, California; 5 Centre Hospitalier de l’Universite de Laval-Centre Hospitalier de l’Université de Québec, Sainte-Foy, Quebec, Canada; 6 Leiden University Medical Center, Leiden, the Netherlands; and 7 University of Vienna, Vienna, Austria

Two mutations of the ATM gene were recently suggested to confer breast cancer risks similar to mutations of BRCA1 or BRCA2. Here, we set out to confirm these findings in 961 families with non-BRCA1/BRCA2 breast cancer from diverse geographical regions. We did not detect the ATM 7271T->G mutation in any family. The ATM IVS10–6T->G mutation was detected in eight families, which was similar to its frequency among population-matched control individuals (pooled Mantel-Haenszel odds ratio = 1.60; 95% confidence interval = 0.48 to 5.35; P = 0.44). Bayesian analysis of linkage in the ATM IVS10–6T->G-positive families showed an overall posterior probability of causality for this mutation of 0.008. We conclude that the ATM IVS10–6T->G mutation does not confer a significantly elevated breast cancer risk and that ATM 7271T->G is a rare event in familial breast cancer.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
S. Lu, K. Shen, Y. Wang, S. J. Santner, J. Chen, S.C. Brooks, and Y.A. Wang
Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors
Carcinogenesis, April 1, 2006; 27(4): 848 - 855.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T.J. Bowen, H. Yakushiji, C. Montagna, S. Jain, T. Ried, and A. Wynshaw-Boris
Atm Heterozygosity Cooperates with Loss of Brca1 to Increase the Severity of Mammary Gland Cancer and Reduce Ductal Branching
Cancer Res., October 1, 2005; 65(19): 8736 - 8746.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
J. Zhang and S. N. Powell
The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair
Mol. Cancer Res., October 1, 2005; 3(10): 531 - 539.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A M R Taylor and P J Byrd
Molecular pathology of ataxia telangiectasia
J. Clin. Pathol., October 1, 2005; 58(10): 1009 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. W. Butch, H. H. Chun, S. A. Nahas, and R. A. Gatti
Immunoassay to Measure Ataxia-Telangiectasia Mutated Protein in Cellular Lysates
Clin. Chem., December 1, 2004; 50(12): 2302 - 2308.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.