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[Cancer Research 64, 969-976, February 1, 2004]
© 2004 American Association for Cancer Research

Regular Articles

RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer

Chengzhen Ren1, Likun Li1, Guang Yang1, Terry L. Timme1,2, Alexei Goltsov1, Chenghui Ren1, Xiaorong Ji1, Josephine Addai1, Hongbin Luo3, Michael M. Ittmann2,3 and Timothy C. Thompson1,2,4,5

1 Scott Department of Urology, Baylor College of Medicine, Houston, Texas; 2 Houston Veterans Affairs Medical Center, Houston, Texas; and Departments of 3 Pathology, 4 Molecular and Cellular Biology, and 5 Radiology, Baylor College of Medicine, Houston, Texas

We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.




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Copyright © 2004 by the American Association for Cancer Research.