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ß-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

¹ Pathologisches Institut der Universität Erlangen-Nürnberg, Erlangen, Germany; ² Universitair Medisch Centrum Utrecht, Department of Medical Oncology, Utrecht, the Netherlands; and ³ Frauenklinik und Poliklinik der TU München, Klinikum rechts der Isar, München, Germany

Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear ß-catenin and is therefore a region expressing ß-catenin target genes at high levels. Here we show that ß-catenin contributes to the transactivation of uPA. Therefore, ß-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.

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