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[Cancer Research 64, 1229-1232, February 15, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Emmprin Promotes Anchorage-Independent Growth in Human Mammary Carcinoma Cells by Stimulating Hyaluronan Production

Erica A. Marieb1, Alexandra Zoltan-Jones1, Rongsong Li1, Suniti Misra1, Shibnath Ghatak1, Jian Cao2, Stanley Zucker2 and Bryan P. Toole1

1 Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts, and 2 Departments of Research and Medicine, Veterans Affairs Medical Center, Northport, New York

Emmprin (CD147; basigin) is a plasma membrane glycoprotein, enriched on the surface of many cancer cells, which induces matrix metalloproteinase synthesis via cell-cell interactions. Elevated emmprin production causes increased growth in vivo of human mammary carcinoma cells. In this study, we show that elevation of emmprin expression in less aggressive human carcinoma cells, which normally express low emmprin levels, induces the ability to grow under anchorage-independent conditions. We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan. Furthermore, emmprin stimulates cell survival pathway signaling in a hyaluronan-dependent manner. From these and other studies we conclude that emmprin enhances several malignant properties of cancer cells, including anchorage-independent growth, invasiveness, and chemoresistance.




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