Cancer Research Annual Meeting 2010 Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roodi, N.
Right arrow Articles by Parl, F. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roodi, N.
Right arrow Articles by Parl, F. F.
[Cancer Research 64, 1233-1236, February 15, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Association of Homozygous Wild-Type Glutathione S-Transferase M1 Genotype with Increased Breast Cancer Risk

Nady Roodi1, William D. Dupont2, Jason H. Moore3 and Fritz F. Parl1

Departments of1 Pathology, 2 Preventive Medicine and Biostatistics, and 3 Molecular Physiology and Biophysics, Program in Human Genetics and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee

More than 500 studies have examined the association of the glutathione S-transferase M1 (GSTM1) genotype with various malignancies yielding inconsistent results. The genotyping was based on a PCR assay that identified the GSTM1 null (-/-) genotype but did not distinguish homozygous wild-type (+/+) and heterozygous (+/-) individuals. We developed an assay that allowed the definition of +/+, +/-, and -/- genotypes by separate identification of wild-type and null alleles, which were found with frequencies of 0.225 and 0.775, respectively, in Caucasian women. We applied the new assay to a breast cancer case-control study and identified the +/+ genotype in 14 (6.9%) of 202 control subjects compared with 37 (18.2%) of 203 patients. Compared with women with the -/- genotype, the relative risk of breast cancer for the +/+ genotype was 2.83 (95% confidence interval, 1.45–5.59; P = 0.002), suggesting a protective effect of the GSTM1 deletion.




This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
F. Parl
A Need for True GSTM1 and GSTT1 Genotyping
Cancer Epidemiol. Biomarkers Prev., October 1, 2009; 18(10): 2793 - 2793.
[Full Text] [PDF]

Home page
 FASEB J.Home page
K.-D. Yu, G.-H. Di, L. Fan, J. Wu, Z. Hu, Z.-Z. Shen, W. Huang, and Z.-M. Shao
A functional polymorphism in the promoter region of GSTM1 implies a complex role for GSTM1 in breast cancer
FASEB J, July 1, 2009; 23(7): 2274 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
T. R. Knight, S. Choudhuri, and C. D. Klaassen
Induction of Hepatic Glutathione S-Transferases in Male Mice by Prototypes of Various Classes of Microsomal Enzyme Inducers
Toxicol. Sci., December 1, 2008; 106(2): 329 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
X. Guo, S. J. O'Brien, Y. Zeng, G. W. Nelson, and C. A. Winkler
GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese
Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1760 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S.E. Steck, M.M. Gaudet, J.A. Britton, S.L. Teitelbaum, M.B. Terry, A.I. Neugut, R.M. Santella, and M.D. Gammon
Interactions among GSTM1, GSTT1 and GSTP1 polymorphisms, cruciferous vegetable intake and breast cancer risk
Carcinogenesis, September 1, 2007; 28(9): 1954 - 1959.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. E. Steck, M. D. Gammon, J. R. Hebert, D. E. Wall, and S. H. Zeisel
GSTM1, GSTT1, GSTP1, and GSTA1 Polymorphisms and Urinary Isothiocyanate Metabolites following Broccoli Consumption in Humans
J. Nutr., April 1, 2007; 137(4): 904 - 909.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Oldenburg, S. M. Kraggerud, M. Cvancarova, R. A. Lothe, and S. D. Fossa
Cisplatin-Induced Long-Term Hearing Impairment Is Associated With Specific Glutathione S-Transferase Genotypes in Testicular Cancer Survivors
J. Clin. Oncol., February 20, 2007; 25(6): 708 - 714.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. Kirsch-Volders, R. A. Mateuca, M. Roelants, A. Tremp, E. Zeiger, S. Bonassi, N. Holland, W. P. Chang, P. V. Aka, M. DeBoeck, et al.
The Effects of GSTM1 and GSTT1 Polymorphisms on Micronucleus Frequencies in Human Lymphocytes In vivo.
Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 1038 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. A. Canter, A. R. Kallianpur, F. F. Parl, and R. C. Millikan
Mitochondrial DNA G10398A Polymorphism and Invasive Breast Cancer in African-American Women
Cancer Res., September 1, 2005; 65(17): 8028 - 8033.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2004 by the American Association for Cancer Research.