This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ngo, T. H. Articles by Aronson, W. J. Search for Related Content PubMed PubMed Citation Articles by Ngo, T. H. Articles by Aronson, W. J.

Effect of Isocaloric Low-Fat Diet on Prostate Cancer Xenograft Progression to Androgen Independence

¹ Departments of Physiological Science, ² Medicine, ³ Biostatistics, and ⁴ Urology, University of California, Los Angeles, Los Angeles, California

An isocaloric low-fat diet has been shown to slow androgen-sensitive Los Angeles Prostate Cancer-4 (LAPC-4) tumor growth in a mouse xenograft model. LAPC-4 cells were injected into male severe combined immunodeficient mice. After palpable tumors developed, the mice were divided into three groups, high-fat intact, high-fat castration, and low-fat castration. Tumor latency (18 versus 9 weeks; P < 0.001) and mouse survival (20.8 ± 1.3 versus 13 ± 0.7 weeks; P < 0.01) were significantly longer in the low-fat castration versus high-fat castration group. Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts.

This article has been cited by other articles:

				C. H. Brown, S. M. Baidas, J. J. Hajdenberg, O. R. Kayaleh, G. K. Pennock, N. C. Shah, and J. E. Tseng Lifestyle Interventions in the Prevention and Treatment of Cancer American Journal of Lifestyle Medicine, September 1, 2009; 3(5): 337 - 348. [Abstract] [PDF]

				J. C. Mavropoulos, W. C. Buschemeyer III, A. K. Tewari, D. Rokhfeld, M. Pollak, Y. Zhao, P. G. Febbo, P. Cohen, D. Hwang, G. Devi, et al. The Effects of Varying Dietary Carbohydrate and Fat Content on Survival in a Murine LNCaP Prostate Cancer Xenograft Model Cancer Prevention Research, June 1, 2009; 2(6): 557 - 565. [Abstract] [Full Text] [PDF]

				M. B. Rettig, D. Heber, J. An, N. P. Seeram, J. Y. Rao, H. Liu, T. Klatte, A. Belldegrun, A. Moro, S. M. Henning, et al. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-{kappa}B-dependent mechanism Mol. Cancer Ther., September 1, 2008; 7(9): 2662 - 2671. [Abstract] [Full Text] [PDF]

				M. F. McEntee, C. Ziegler, D. Reel, K. Tomer, A. Shoieb, M. Ray, X. Li, N. Neilsen, F. B. Lih, D. O'Rourke, et al. Dietary n-3 Polyunsaturated Fatty Acids Enhance Hormone Ablation Therapy in Androgen-Dependent Prostate Cancer Am. J. Pathol., July 1, 2008; 173(1): 229 - 241. [Abstract] [Full Text] [PDF]

				D. W. Lin, M. L. Neuhouser, J. M. Schenk, I. M. Coleman, S. Hawley, D. Gifford, H. Hung, B. S. Knudsen, P. S. Nelson, and A. R. Kristal Low-Fat, Low-Glycemic Load Diet and Gene Expression in Human Prostate Epithelium: A Feasibility Study of Using cDNA Microarrays to Assess the Response to Dietary Intervention in Target Tissues Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2150 - 2154. [Abstract] [Full Text] [PDF]

				S. J. Freedland Obesity and Prostate Cancer: A Growing Problem Clin. Cancer Res., October 1, 2005; 11(19): 6763 - 6766. [Full Text] [PDF]