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[Cancer Research 64, 1589-1594, March 1, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

PrLZ, a Novel Prostate-Specific and Androgen-Responsive Gene of the TPD52 Family, Amplified in Chromosome 8q21.1 and Overexpressed in Human Prostate Cancer

Ruoxiang Wang1, Jianchun Xu1, Outi Saramäki4, Tapio Visakorpi4, William M. Sutherland5, Jianguang Zhou1, Buer Sen1, So Dug Lim2, Nicola Mabjeesh3, Mahul Amin2, Jin-Tang Dong3, John A. Petros1, Peter S. Nelson6, Fray F. Marshall1, Haiyen E. Zhau1 and Leland W. K. Chung1

1 Molecular Urology and Therapeutics, Department of Urology, 2 Department of Pathology, and 3 Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia; 4 Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland; 5 Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia; and 6 Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington

We report a previously unrecognized prostate-specific protein, PrLZ (prostate leucine zipper), a new member of the Tumor Protein D52 (TPD52) family. The gene for PrLZ was localized at chromosome 8q21.1, a locus most frequently amplified in human prostate cancer. Multiple tissue analyses demonstrated PrLZ predominantly in the prostate gland. Although its expression was enhanced by androgens in androgen receptor-expressing cells, PrLZ was detected in all of the human prostate cancer cell lines, regardless of androgen receptor status. Monoclonal anti-PrLZ antibodies were produced and intense immunohistochemical staining of PrLZ was observed in prostate epithelial cells in intraepithelial neoplasia and prostate cancer, whereas lower-level staining was detected in normal and benign epithelial components of the prostate gland. As the only prostate-specific gene identified in the most frequently amplified genomic region in prostate cancer, PrLZ may be the link between chromosome 8q amplification and malignant transformation of the prostate epithelia.




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Copyright © 2004 by the American Association for Cancer Research.