This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Diehl, D. Articles by Lahm, H. Search for Related Content PubMed PubMed Citation Articles by Diehl, D. Articles by Lahm, H.

Insulin-like Growth Factor (IGF)-binding Protein-4 Inhibits Colony Formation of Colorectal Cancer Cells by IGF-independent Mechanisms

Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University of Munich, Munich, Germany

Effects of insulin-like growth factor-binding protein-4 (IGFBP-4) on proliferation, colony formation, and cell migration were assessed in IGF-sensitive and -insensitive colorectal cancer cell lines. In IGF-insensitive Isreco-1 cells, overexpression of IGFBP-4 reduced colony formation but not cell proliferation and migration, whereas exogenous IGF-II had no effect. In IGF-dependent LS1034 cells, IGFBP-4 inhibited all parameters of growth tested, whereas IGF-II partially restored reduced proliferation and cell migration only. In Isreco-2 cells, which lack endogenous IGF expression but are IGF sensitive, colony formation was also reduced by IGFBP-4. Therefore, specific parameters of malignant progression of colon carcinoma cells are distinctly affected by IGF-dependent and IGF-independent effects of IGFBP-4.

This article has been cited by other articles:

				F. A. Simmen, R. Xiao, M. C. Velarde, R. D. Nicholson, M. T. Bowman, Y. Fujii-Kuriyama, S. P. Oh, and R. C. M. Simmen Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9 Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1757 - G1769. [Abstract] [Full Text] [PDF]