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Recent Advances in Stress Signaling in Cancer

Centre de recherche en cancérologie de l’Université Laval, Québec, Canada

ABSTRACT

This meeting brought together some of the world’s leading scientists in the field of stress signaling, apoptosis, and cancer. This resulted in a productive interaction that updated our current knowledge on "Stress Signaling in Cancer." It comes out that subtle disturbances in cell signaling can be associated with and even lead to cancer. As a corollary, it appears that correcting the signaling defects associated with cancer constitutes a new approach to the treatment and control of neoplastic diseases. The meeting also raised several questions that should be addressed. In particular, it is of the utmost importance to better understand the mechanisms that underlie the specificity of the cellular response with regard to different ligands. For example, why does Gadd45b prevent apoptotic cell death in response to tumor necrosis factor , whereas it favors apoptosis after transforming growth factor ß (E. De Smaele et al., Nature (Lond.), 414: 308–313, 2001; J. Yoo et al., J. Biol. Chem., 278: 43001–43007, 2003). Other questions concern the understanding of the cross-talk mechanisms between different stress and apoptotic pathways and how the strength and the position and timing of a signal may affect different pathways. The next few years of research in this field should be enlightening and fruitful.

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