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[Cancer Research 64, 1902-1905, March 15, 2004]
© 2004 American Association for Cancer Research

Review

Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-{kappa}B (NF-{kappa}B) and c-Jun NH2-terminal Kinase (JNK)

Yadong Zhang1 and Fei Chen1,2

1 Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, P. R. China; and 2 The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia

Nuclear factor-{kappa}B (NF-{kappa}B) and c-Jun NH2-terminal kinase (JNK) are activated simultaneously under a variety of stress conditions. They also share several common signaling pathways for their activation in response to cytokines or growth factors. Recent studies, however, demonstrated a new form of interplay between these two allies. Inhibition of NF-{kappa}B by ikkß or rela gene deficiency sensitizes stress responses through enhanced or prolonged activation of JNK. Conversely, sustained activation of NF-{kappa}B inhibits cytokine-induced JNK activation. The mechanisms of how NF-{kappa}B and JNK become rivals for each other are under extensive debate.




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