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Accelerated Induction of Bladder Cancer in Patched Heterozygous Mutant Mice

¹ Laval University Cancer Research Centre, and ² Department of Pathology, Centre Hospitalier Universitaire de Québec-L’Hôtel-Dieu de Québec, Quebec, Quebec, Canada

The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc^+/- heterozygous mutant mice and their wild-type littermates to chemical carcinogenesis by adding N-butyl-N-(4-hydroxybutyl) nitrosamine to their drinking water. Preneoplastic and neoplastic changes were observed significantly earlier in the Ptc^+/- than in the wild-type mice. Our data support the hypothesis of Ptc acting as a tumor suppressor gene in bladder cancer.

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