| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
1 Cancer Research Institute, 2 National Laboratory of Medical Genetics, and 3 The Third Xiangya Hospital, Central South University, ChangSha, Hunan; 4 Shanghai Mental Health Center and 5 Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai; and 6 Shanghai Institute for Biological Science, Chinese Academy of Science, Shanghai, China
Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed.
This article has been cited by other articles:
|
|
 |
|
  M.-C. Chen, I.-J. Feng, C.-H. Lu, C.-C. Chen, J.-T. Lin, S.-H. Huang, and K.-D. Lee The incidence and risk of second primary cancers in patients with nasopharyngeal carcinoma: a population-based study in Taiwan over a 25-year period (1979-2003) Ann. Onc., June 1, 2008; 19(6): 1180 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-L. Cheng, W.-G. Huang, Z.-C. Chen, F. Peng, P.-F. Zhang, M.-Y. Li, F. Li, J.-L. Li, C. Li, H. Yi, et al. Identification of Novel Nasopharyngeal Carcinoma Biomarkers by Laser Capture Microdissection and Proteomic Analysis Clin. Cancer Res., January 15, 2008; 14(2): 435 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zhou, Y. Zhai, Y. Cui, X. Zhang, X. Dong, H. Yang, Y. He, K. Yao, H. Zhang, L. Zhi, et al. MDM2 Promoter SNP309 Is Associated with Risk of Occurrence and Advanced Lymph Node Metastasis of Nasopharyngeal Carcinoma in Chinese Population Clin. Cancer Res., May 1, 2007; 13(9): 2627 - 2633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Chang and H.-O. Adami The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1765 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Friborg, J. Wohlfahrt, A. Koch, H. Storm, O. R. Olsen, and M. Melbye Cancer Susceptibility in Nasopharyngeal Carcinoma Families--A Population-Based Cohort Study Cancer Res., September 15, 2005; 65(18): 8567 - 8572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.(R. Yang, S. Diehl, R. Pfeiffer, C.-J. Chen, W.-L. Hsu, M. Dosemeci, Y.-J. Cheng, B. Sun, A. M. Goldstein, A. Hildesheim, et al. Evaluation of Risk Factors for Nasopharyngeal Carcinoma in High-Risk Nasopharyngeal Carcinoma Families in Taiwan Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y He, G Zhou, Y Zhai, X Dong, L Lv, F He, and K Yao Association of PLUNC gene polymorphisms with susceptibility to nasopharyngeal carcinoma in a Chinese population J. Med. Genet., February 1, 2005; 42(2): 172 - 176. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
