This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Monzavi-Karbassi, B. Articles by Kieber-Emmons, T. Search for Related Content PubMed PubMed Citation Articles by Monzavi-Karbassi, B. Articles by Kieber-Emmons, T.

A Mimic of Tumor Rejection Antigen-Associated Carbohydrates Mediates an Antitumor Cellular Response

¹ University of Arkansas for Medical Sciences, Little Rock, Arkansas, and ² Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Tumor-associated carbohydrate antigens are typically perceived as inadequate targets for generating tumor-specific cellular responses. Lectin profile reactivity and crystallographic studies demonstrate that MHC class I molecules can present to the immune system posttranslationally modified cytosolic peptides carrying O-ß-linked N-acetylglucosamine (GlcNAc). Here we report that a peptide surrogate of GlcNAc can facilitate an in vivo tumor-specific cellular response to established Meth A tumors that display native O-GlcNAc glycoproteins on the tumor cell surface. Peptide immunization of tumor-bearing mice had a moderate effect on tumor regression. Inclusion of interleukin 12 in the immunization regimen stimulated complete elimination of tumor cells in all of the mice tested, whereas interleukin 12 administration alone afforded no tumor growth inhibition. Adoptive transfer of immune T cells into tumor-bearing nude mice indicates a role for CD8+ T cells in tumor regression. This work postulates that peptide mimetics of glycosylated tumor rejection antigens might be further developed for immune therapy of cancer.

This article has been cited by other articles:

				T. Satomaa, A. Heiskanen, I. Leonardsson, J. Angstrom, A. Olonen, M. Blomqvist, N. Salovuori, C. Haglund, S. Teneberg, J. Natunen, et al. Analysis of the Human Cancer Glycome Identifies a Novel Group of Tumor-Associated N-Acetylglucosamine Glycan Antigens Cancer Res., July 15, 2009; 69(14): 5811 - 5819. [Abstract] [Full Text] [PDF]

				A. Wierzbicki, M. Gil, M. Ciesielski, R. A. Fenstermaker, Y. Kaneko, H. Rokita, J. T. Lau, and D. Kozbor Immunization with a Mimotope of GD2 Ganglioside Induces CD8+ T Cells That Recognize Cell Adhesion Molecules on Tumor Cells J. Immunol., November 1, 2008; 181(9): 6644 - 6653. [Abstract] [Full Text] [PDF]

				B. Monzavi-Karbassi, C. Artaud, F. Jousheghany, L. Hennings, J. Carcel-Trullols, S. Shaaf, S. Korourian, and T. Kieber-Emmons Reduction of Spontaneous Metastases through Induction of Carbohydrate Cross-Reactive Apoptotic Antibodies J. Immunol., June 1, 2005; 174(11): 7057 - 7065. [Abstract] [Full Text] [PDF]