This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hagmar, L. Articles by Norppa, H. Search for Related Content PubMed PubMed Citation Articles by Hagmar, L. Articles by Norppa, H.

Impact of Types of Lymphocyte Chromosomal Aberrations on Human Cancer Risk

Results from Nordic and Italian Cohorts

¹ Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden; ² Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; ³ Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway; ⁴ Department of Environmental Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark; ⁵ Radiation and Nuclear Safety Authority, Helsinki, Finland; and ⁶ Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland

The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood lymphocytes is the first genotoxicity biomarker that has shown an association with cancer risk. CAs are usually divided into chromosome-type (CSAs) and chromatid-type aberrations (CTAs), with different mechanisms of formation. From a mechanistic point of view, it is of interest to clarify whether the cancer predictivity of CAs is different with respect to CSAs and CTAs. We report here cancer risk for cytogenetically tested, healthy subjects with respect to frequency of CAs, CSAs, and CTAs in peripheral blood lymphocytes, using Nordic (1981 subjects with CA data, 1871 subjects with CSA/CTA data) and Italian (1573 subjects with CA data, 877 subjects with CTA/CSA data) cohorts, with a median follow-up of 17 years. High levels of CAs at test were clearly associated with increased total cancer incidence in the Nordic cohorts and increased total cancer mortality in the Italian cohort. In the Nordic cohorts, significantly elevated cancer risks were observed for subjects with both high CSAs and high CTAs at test, and these variables showed equally strong cancer predictivity. The results of the Italian cohort did not indicate any clear-cut difference in cancer predictivity between the CSA and CTA biomarkers. There was no significant effect modification by age at test, gender, country, or time since test. The results suggest that both DNA double-strand breaks and other initial DNA lesions responsible for CSAs and CTAs are associated with cancer risk.

This article has been cited by other articles:

				J. M. Battershill, K. Burnett, and S. Bull Factors affecting the incidence of genotoxicity biomarkers in peripheral blood lymphocytes: impact on design of biomonitoring studies Mutagenesis, November 1, 2008; 23(6): 423 - 437. [Abstract] [Full Text] [PDF]

				S. Bonassi, H. Norppa, M. Ceppi, U. Stromberg, R. Vermeulen, A. Znaor, A. Cebulska-Wasilewska, E. Fabianova, A. Fucic, S. Gundy, et al. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries Carcinogenesis, June 1, 2008; 29(6): 1178 - 1183. [Abstract] [Full Text] [PDF]

				L. Godderis, P Aka, M Kirsch-Volders, and H Veulemans Comparison of genotoxic potency of styrene 7,8-oxide with {gamma} radiation and human cancer risk estimation of styrene using the rad-equivalence approach Mutagenesis, May 1, 2007; 22(3): 209 - 215. [Abstract] [Full Text] [PDF]

				S. Bonassi, A. Znaor, M. Ceppi, C. Lando, W. P. Chang, N. Holland, M. Kirsch-Volders, E. Zeiger, S. Ban, R. Barale, et al. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans Carcinogenesis, March 1, 2007; 28(3): 625 - 631. [Abstract] [Full Text] [PDF]

				P. Boffetta, O. van der Hel, H. Norppa, E. Fabianova, A. Fucic, S. Gundy, J. Lazutka, A. Cebulska-Wasilewska, D. Puskailerova, A. Znaor, et al. Chromosomal Aberrations and Cancer Risk: Results of a Cohort Study from Central Europe Am. J. Epidemiol., January 1, 2007; 165(1): 36 - 43. [Abstract] [Full Text] [PDF]

				C. Costa, J. P. Teixeira, S. Silva, J. Roma-Torres, P. Coelho, J. Gaspar, M. Alves, B. Laffon, J. Rueff, and O. Mayan Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides Mutagenesis, September 1, 2006; 21(5): 343 - 350. [Abstract] [Full Text] [PDF]

				E. Erdei, S.-J. Lee, Q. Wei, L.-E. Wang, Y.-S. Song, D. Bovbjerg, and M. Berwick Reliability of mutagen sensitivity assay: an inter-laboratory comparison Mutagenesis, July 1, 2006; 21(4): 261 - 264. [Abstract] [Full Text] [PDF]

				E. Fragedaki, M. Nebel, N. Schupp, K. Sebekova, W. Volkel, A. Klassen, M. Pischetsrieder, M. Frischmann, T. Niwa, J. Vienken, et al. Genomic damage and circulating AGE levels in patients undergoing daily versus standard haemodialysis Nephrol. Dial. Transplant., September 1, 2005; 20(9): 1936 - 1943. [Abstract] [Full Text] [PDF]

				S. Kyoizumi, Y. Kusunoki, T. Hayashi, M. Hakoda, J. B. Cologne, and K. Nakachi Individual Variation of Somatic Gene Mutability in Relation to Cancer Susceptibility: Prospective Study on Erythrocyte Glycophorin A Gene Mutations of Atomic Bomb Survivors Cancer Res., June 15, 2005; 65(12): 5462 - 5469. [Abstract] [Full Text] [PDF]

				Y.-C. Chen and D. J. Hunter Molecular Epidemiology of Cancer CA Cancer J Clin, January 1, 2005; 55(1): 45 - 54. [Abstract] [Full Text] [PDF]