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[Cancer Research 64, 2307-2316, April 1, 2004]
© 2004 American Association for Cancer Research

Reviews

Classification of Proliferative Pulmonary Lesions of the Mouse

Recommendations of the Mouse Models of Human Cancers Consortium

Alexander Yu. Nikitin1, Ana Alcaraz1, Miriam R. Anver2, Roderick T. Bronson3, Robert D. Cardiff4, Darlene Dixon5, Armando E. Fraire6, Edward W. Gabrielson7, William T. Gunning8, Diana C. Haines2, Matthew H. Kaufman9, R. Ilona Linnoila10, Robert R. Maronpot5, Alan S. Rabson11, Robert L. Reddick12, Sabine Rehm13, Nora Rozengurt14, Hildegard M. Schuller15, Elena N. Shmidt1, William D. Travis16, Jerrold M. Ward17 and Tyler Jacks18

1 Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York; 2 Veterinary Pathology Section, Pathology/Histotechnology Laboratory, Science Applications International Corporation, National Cancer Institute, NIH, Frederick, Maryland; 3 Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts; 4 Center for Comparative Medicine, University of California, Davis, California; 5 Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; 6 Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts; 7 Departments of Pathology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 8 Department of Pathology, Medical College of Ohio, Toledo, Ohio; 9 Department of Anatomy, Edinburgh University, Edinburgh, United Kingdom; 10 Cell and Cancer Biology Department, Center for Cancer Research, National Cancer Institute, NIH, Rockville, Maryland; 11 National Cancer Institute, NIH, Bethesda, Maryland; 12 Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas; 13 GlaxoSmithKline, King of Prussia, Pennsylvania; 14 Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine, University of California, Los Angeles, California; 15 Department of Pathology, Experimental Oncology Laboratory; College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee; 16 Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC; 17 Veterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, NIH, Frederick, Maryland; and 18 Department of Biology, Massachusetts Institute of Technology and Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts

Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed according to incongruent human and mouse classifications. Thus, comparative characterization and validation of novel models can be difficult. To address these issues, a series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer held in Boston on June 20–22, 2001. The panel performed a comparative evaluation of 78 cases of mouse and human lung proliferative lesions, and recommended development of a new practical classification scheme that would (a) allow easier comparison between human and mouse lung neoplasms, (b) accommodate newly emerging mouse neoplasms, and (c) address the interpretation of benign and preinvasive lesions of the mouse lung. Subsequent discussions with additional experts in pulmonary pathology resulted in the current proposal of a new classification. It is anticipated that this classification, as well as the complementary digital atlas of virtual histological slides, will help investigators and pathologists in their characterization of new mouse models, as well as stimulate further research aimed at a better understanding of proliferative lesions of the lung.




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