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[Cancer Research 64, 2984-2987, May 1, 2004]
© 2004 American Association for Cancer Research

Advances in Brief

Depletion of Methionine Aminopeptidase 2 Does Not Alter Cell Response to Fumagillin or Bengamides

Sunkyu Kim, Kenneth LaMontagne, Michael Sabio, Sushil Sharma, Richard W. Versace, Naeem Yusuff and Penny E. Phillips

Novartis Pharmaceuticals, East Hanover, New Jersey

Inhibition of endothelial cell growth by fumagillin has been assumed to be mediated by inhibition of the molecular target methionine aminopeptidase 2 (MetAp2). New data show that depletion of MetAp2 by siRNA does not inhibit endothelial cell growth. Moreover, MetAp2-depleted endothelial cells remain responsive to inhibition by either fumagillin or a newly identified MetAp2 enzyme inhibitor. These data suggest that MetAp2 function is not required for endothelial cell proliferation.




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Copyright © 2004 by the American Association for Cancer Research.