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Human T-Cell Leukemia Virus Type I at Age 25: A Progress Report

¹ Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan and ² Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland

Requests for reprints: Kuan-Teh Jeang, Building 4, Room 306, 9000 Rockville Pike, Bethesda, MD 20892-0460. Phone: 301-496-6680; Fax: 301-480-3686; E-mail: kj7e{at}nih.gov.

It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.

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