| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Priority Reports |
Departments of 1 Gene and Cell Medicine and 2 Biochemistry and Pharmacology, 3 Immunobiology Center, Mount Sinai School of Medicine; 4 Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York; and 5 Department of Immunology, Shanghai Medical College, Fudan University, Shanghai
Requests for reprints: Huabao Xiong, Immunobiology Center, Box 1630, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029-6574. Phone: 212-659-9413; Fax: 212-849-2525; E-mail: Huabao.Xiong{at}mssm.edu.
The signal pathways that trigger tumor cell escape from immune surveillance are incompletely understood. Toll-like receptors (TLRs), which activate innate and adaptive immune responses, are thought to be restricted to immune cells. We show here that TLRs, including TLR4, are expressed on tumor cells from a wide variety of tissues, suggesting that TLR activation may be an important event in tumor cell immune evasion. Activation of TLR4 signaling in tumor cells by lipopolysaccharide induces the synthesis of various soluble factors and proteins including interleukin-6, inducible nitric oxide synthase, interleukin-12, B7-H1, and B7-H2, and results in resistance of tumor cells to CTL attack. In addition, lipopolysaccharide-stimulated tumor cell supernatants inhibit both T cell proliferation and natural killer cell activity. Blockade of the TLR4 pathway by either TLR4 short interfering RNA or a cell-permeable TLR4 inhibitory peptide reverses tumor-mediated suppression of T cell proliferation and natural killer cell activity in vitro, and in vivo, delays tumor growth and thus prolongs the survival of tumor-bearing mice. These findings indicate that TLR signaling results in a cascade leading to tumor evasion from immune surveillance. These novel functions of TLRs in tumor biology suggest a new class of therapeutic targets for cancer therapy.
This article has been cited by other articles:
|
|
 |
|
  B. Huang, Z. Lei, G.-M. Zhang, D. Li, C. Song, B. Li, Y. Liu, Y. Yuan, J. Unkeless, H. Xiong, et al. SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment Blood, August 15, 2008; 112(4): 1269 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lafon, F. Megret, S. G. Meuth, O. Simon, M. L. Velandia Romero, M. Lafage, L. Chen, L. Alexopoulou, R. A. Flavell, C. Prehaud, et al. Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis J. Immunol., June 1, 2008; 180(11): 7506 - 7515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chochi, T. Ichikura, M. Kinoshita, T. Majima, N. Shinomiya, H. Tsujimoto, T. Kawabata, H. Sugasawa, S. Ono, S. Seki, et al. Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells Clin. Cancer Res., May 15, 2008; 14(10): 2909 - 2917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Weck, S. Appel, D. Werth, C. Sinzger, A. Bringmann, F. Grunebach, and P. Brossart hDectin-1 is involved in uptake and cross-presentation of cellular antigens Blood, April 15, 2008; 111(8): 4264 - 4272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Adam, B. Schmausser, M. Gobeler-Kolve, H. K. Muller-Hermelink, and M. Eck Gastric extranodal marginal zone B-cell lymphomas of MALT type exclusively express toll-like receptor 4 in contrast to other lymphomas infiltrating the stomach Ann. Onc., March 1, 2008; 19(3): 566 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Currie, R. G. van der Most, S. A. Broomfield, A. C. Prosser, M. G. Tovey, and B. W. S. Robinson Targeting the Effector Site with IFN-{alpha}{beta}-Inducing TLR Ligands Reactivates Tumor-Resident CD8 T Cell Responses to Eradicate Established Solid Tumors J. Immunol., February 1, 2008; 180(3): 1535 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Y. Cannon, D. Guttridge, J. Dahlman, J. R. George, V. Lai, C. Shores, P. Buzkova, and M. E. Couch The Effect of Altered Toll-like Receptor 4 Signaling on Cancer Cachexia Arch Otolaryngol Head Neck Surg, December 1, 2007; 133(12): 1263 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Andreani, G. Gatti, L. Simonella, V. Rivero, and M. Maccioni Activation of Toll-like Receptor 4 on Tumor Cells In vitro Inhibits Subsequent Tumor Growth In vivo Cancer Res., November 1, 2007; 67(21): 10519 - 10527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Morikawa, A. Sugiyama, H. Kume, S. Ota, T. Kashima, K. Tomita, T. Kitamura, T. Kodama, M. Fukayama, and H. Aburatani Identification of Toll-Like Receptor 3 as a Potential Therapeutic Target in Clear Cell Renal Cell Carcinoma Clin. Cancer Res., October 1, 2007; 13(19): 5703 - 5709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Salaun, S. Lebecque, S. Matikainen, D. Rimoldi, and P. Romero Toll-like Receptor 3 Expressed by Melanoma Cells as a Target for Therapy? Clin. Cancer Res., August 1, 2007; 13(15): 4565 - 4574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, A. Hamrouni, D. Wolowiec, V. Coiteux, K. Kuliczkowski, D. Hetuin, A. Saudemont, and B. Quesnel Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway Blood, July 1, 2007; 110(1): 296 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Huang, J. Zhao, S. Shen, H. Li, K.-L. He, G.-X. Shen, L. Mayer, J. Unkeless, D. Li, Y. Yuan, et al. Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling Cancer Res., May 1, 2007; 67(9): 4346 - 4352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xiao, B. Huang, Y. Yuan, D. Li, L.-F. Han, Y. Liu, W. Gong, F.-H. Wu, G.-M. Zhang, and Z.-H. Feng Soluble PD-1 Facilitates 4-1BBL-Triggered Antitumor Immunity against Murine H22 Hepatocarcinoma In vivo Clin. Cancer Res., March 15, 2007; 13(6): 1823 - 1830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ito, R. A. DeMarco, R. B. Mailliard, J. Han, H. Rabinowich, P. Kalinski, D. B. Stolz, H. J. Zeh III, and M. T. Lotze Cytolytic cells induce HMGB1 release from melanoma cell lines J. Leukoc. Biol., January 1, 2007; 81(1): 75 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-X. Zhou, W.-H. Jia, G.-P. Shen, H.-d. Qin, X.-J. Yu, L.-Z. Chen, Q.-S. Feng, Y. Y. Shugart, and Y.-X. Zeng Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 862 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Emdad, D. Sarkar, Z.-z. Su, A. Randolph, H. Boukerche, K. Valerie, and P. B. Fisher Activation of the Nuclear Factor {kappa}B Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and Metastasis Cancer Res., February 1, 2006; 66(3): 1509 - 1516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Abouzahr, G. Bismuth, C. Gaudin, O. Caroll, P. Van Endert, A. Jalil, J. Dausset, I. Vergnon, C. Richon, A. Kauffmann, et al. Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure PNAS, January 31, 2006; 103(5): 1428 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Toll-Like Receptors on Tumor Cells Cancer Res., October 1, 2005; 65(19): 9108 - 9108. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
