This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lu, H. Articles by Zheng, W. Search for Related Content PubMed PubMed Citation Articles by Lu, H. Articles by Zheng, W.

Association of Genetic Polymorphisms in the VEGF Gene with Breast Cancer Survival

¹ Department of Medicine, Center for Health Services Research, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee and ² Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

Requests for reprints: Xiao-Ou Shu, Vanderbilt University Center for Health Services Research, 6th Floor, Medical Center East, Nashville, TN 37232-8300. Phone: 615-936-0713; Fax: 615-936-1269; E-mail: xiao-ou.shu{at}vanderbilt.edu.

The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and vascular permeability. VEGF overexpression has been associated with advanced stage and poor survival of several cancers. We evaluated the association of functional polymorphisms in the VEGF gene with breast cancer survival in a cohort of 1,193 breast cancer patients who were recruited as part of a population-based case-control study in Shanghai, China from 1996 to 1998 and followed for cancer recurrence and mortality between March 2000 and December 2002. Included in the study were three functional polymorphisms (C–460T, G+405C, and C+936T) in the VEGF gene. Carrying the –460C or +405G allele was associated with decreased overall survival. The age-adjusted hazard ratios (HR) were 1.5 [95% confidence interval (95% CI), 0.9-2.5] for –460CC genotype carriers and 1.6 (95% CI, 1.0-2.5) for +405GG genotype carriers compared with noncarriers. Further analyses showed that the –460T/+450C/+936C haplotype was related to increased survival (HR, 0.57; 95% CI, 0.4-0.9), whereas the –460C/+405G/+936T haplotype was associated with nonsignificantly decreased survival (HR, 2.1; 95% CI, –0.9 to 4.7). The C+936T polymorphism alone was not related to overall or disease-free survival. This study suggests that VEGF polymorphisms may be a significant genetic marker for breast cancer prognosis.

This article has been cited by other articles:

				S. Qu, J. Long, Q. Cai, X.-O. Shu, H. Cai, Y.-T. Gao, and W. Zheng Genetic Polymorphisms of Metastasis Suppressor Gene NME1 and Breast Cancer Survival Clin. Cancer Res., August 1, 2008; 14(15): 4787 - 4793. [Abstract] [Full Text] [PDF]

				M. Patel, S. Ailawadhi, F. Hernandez-Ilizaliturri, and G. E. Wilding Vascular Endothelial Growth Factor Polymorphisms in Early-Stage Non-Small-Cell Lung Cancer J. Clin. Oncol., July 1, 2008; 26(19): 3289 - 3290. [Full Text] [PDF]

				R. S. Heist, R. Zhai, G. Liu, W. Zhou, X. Lin, L. Su, K. Asomaning, T. J. Lynch, J. C. Wain, and D. C. Christiani VEGF Polymorphisms and Survival in Early-Stage Non-Small-Cell Lung Cancer J. Clin. Oncol., February 20, 2008; 26(6): 856 - 862. [Abstract] [Full Text] [PDF]

				J. G. Kim, Y. S. Chae, S. K. Sohn, Y. Y. Cho, J. H. Moon, J. Y. Park, S. W. Jeon, I. T. Lee, G. S. Choi, and S.-H. Jun Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer Clin. Cancer Res., January 1, 2008; 14(1): 62 - 66. [Abstract] [Full Text] [PDF]

				R Zhai, M N Gong, W Zhou, T B Thompson, P Kraft, L Su, and D C Christiani Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS Thorax, August 1, 2007; 62(8): 718 - 722. [Abstract] [Full Text] [PDF]

				M. Udler, A.-T. Maia, A. Cebrian, C. Brown, D. Greenberg, M. Shah, C. Caldas, A. Dunning, D. Easton, B. Ponder, et al. Common Germline Genetic Variation in Antioxidant Defense Genes and Survival After Diagnosis of Breast Cancer J. Clin. Oncol., July 20, 2007; 25(21): 3015 - 3023. [Abstract] [Full Text] [PDF]

				J. Kim, S. Sohn, Y. Chae, Y. Cho, H-I Bae, G Yan, J. Park, M-H Lee, H. Chung, and W Yu Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with gastric cancer Ann. Onc., June 1, 2007; 18(6): 1030 - 1036. [Abstract] [Full Text] [PDF]

				L. A. Hefler, A. Mustea, D. Konsgen, N. Concin, B. Tanner, R. Strick, G. Heinze, C. Grimm, E. Schuster, C. Tempfer, et al. Vascular Endothelial Growth Factor Gene Polymorphisms Are Associated with Prognosis in Ovarian Cancer Clin. Cancer Res., February 1, 2007; 13(3): 898 - 901. [Abstract] [Full Text] [PDF]

				J.-R. Long, N. Kataoka, X.-O. Shu, W. Wen, Y.-T. Gao, Q. Cai, and W. Zheng Genetic Polymorphisms of the CYP19A1 Gene and Breast Cancer Survival. Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2115 - 2122. [Abstract] [Full Text] [PDF]

				X. Zhang, X.-O. Shu, Q. Cai, Z. Ruan, Y.-T. Gao, and W. Zheng Functional plasminogen activator inhibitor-1 gene variants and breast cancer survival. Clin. Cancer Res., October 15, 2006; 12(20): 6037 - 6042. [Abstract] [Full Text] [PDF]

				A. J. Churchill, J. G. Carter, H. C. Lovell, C. Ramsden, S. J. Turner, A. Yeung, J. Escardo, and D. Atan VEGF polymorphisms are associated with neovascular age-related macular degeneration Hum. Mol. Genet., October 1, 2006; 15(19): 2955 - 2961. [Abstract] [Full Text] [PDF]

				N. Kataoka, Q. Cai, W. Wen, X.-O. Shu, F. Jin, Y.-T. Gao, and W. Zheng Population-Based Case-Control Study of VEGF Gene Polymorphisms and Breast Cancer Risk among Chinese Women. Cancer Epidemiol. Biomarkers Prev., June 1, 2006; 15(6): 1148 - 1152. [Abstract] [Full Text] [PDF]