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[Cancer Research 65, 5481-5484, July 1, 2005]
© 2005 American Association for Cancer Research

Review Articles

A Single Nucleotide Polymorphism in the MDM2 Gene: From a Molecular and Cellular Explanation to Clinical Effect

Gareth L. Bond, Wenwei Hu and Arnold Levine

The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey and The Institute for Advanced Studies, Princeton, New Jersey

Requests for reprints: Arnold J. Levine, Institute for Advanced Study, School of Natural Sciences, Einstein Drive, Princeton, NJ 08540. Phone: 212-327-8080; Fax: 1-212-327-8900; E-mail: alevine{at}ias.edu.

In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 stress response pathway was chosen given its well-documented importance in tumor suppression. A SNP was found which associates with the attenuation of the p53 pathway and the acceleration of tumor formation in humans and data was presented which describe a molecular mechanism for these phenotypes.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2005 by the American Association for Cancer Research.