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[Cancer Research 65, 5485-5487, July 1, 2005]
© 2005 American Association for Cancer Research

Review Articles

Mammalian Sterile 20–Like Kinases in Tumor Suppression: An Emerging Pathway

Eric E. O'Neill1, David Matallanas1 and Walter Kolch1,2

1 Beatson Insitute for Cancer Research and 2 Sir Henry Welcome Functional Genomics Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Requests for reprints: Walter Kolch, Beatson Insitute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, Scotland G61 1BD, United Kingdom. Phone: 44-141-330-3983; Fax: 44-141-942-6521; E-mail: wkolch{at}beatson.gla.ac.uk.

Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20–like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf–mitogen-activated protein kinase signaling in cancer cells.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
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Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2005 by the American Association for Cancer Research.