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Mammalian Sterile 20–Like Kinases in Tumor Suppression: An Emerging Pathway

¹ Beatson Insitute for Cancer Research and ² Sir Henry Welcome Functional Genomics Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Requests for reprints: Walter Kolch, Beatson Insitute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, Scotland G61 1BD, United Kingdom. Phone: 44-141-330-3983; Fax: 44-141-942-6521; E-mail: wkolch{at}beatson.gla.ac.uk.

Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20–like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf–mitogen-activated protein kinase signaling in cancer cells.

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