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A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration

¹ Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Karlsruhe, Germany and ² Institute of Molecular Biotechnology, Jena, Germany

Requests for reprints: Helmut Ponta, Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Eggenstein-Leopoldshafen, Germany. Phone: 49-724-782-4483; Fax: 49-724-782-3354; E-mail: helmut.ponta{at}itg.fzk.de.

Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH in human. Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration.

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