This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Geiger, T. R. Articles by Peeper, D. S. Search for Related Content PubMed PubMed Citation Articles by Geiger, T. R. Articles by Peeper, D. S. Related Collections Tumor Biology Tumor Biology: Invasion and Metastasis

The Neurotrophic Receptor TrkB in Anoikis Resistance and Metastasis: A Perspective

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands

Requests for reprints: Daniel S. Peeper, Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Phone: 31-20-512-2002; Fax: 31-20-512-2011; E-mail: d.peeper{at}nki.nl.

Resistance to anoikis ("detachment-induced apoptosis") has been suggested to be a prerequisite for cancer cells to metastasize. In a functional screen for suppressors of anoikis, we identified the neurotrophic receptor TrkB. Upon s.c. inoculation in mice, TrkB-expressing cells formed highly invasive and metastatic tumors. Here, we discuss our findings within the context of the proposed role of TrkB in human malignancies and address the question of its feasibility as a target for cancer therapy.

This article has been cited by other articles:

				T. R. Geiger and D. S. Peeper Critical Role for TrkB Kinase Function in Anoikis Suppression, Tumorigenesis, and Metastasis Cancer Res., July 1, 2007; 67(13): 6221 - 6229. [Abstract] [Full Text] [PDF]

				J. M. Lahti, T. Teitz, and D. G. Stupack Does Integrin-Mediated Cell Death Confer Tissue Tropism in Metastasis? Cancer Res., June 15, 2006; 66(12): 5981 - 5984. [Abstract] [Full Text] [PDF]

				H. Osada, Y. Tatematsu, Y. Yatabe, Y. Horio, and T. Takahashi ASH1 Gene Is a Specific Therapeutic Target for Lung Cancers with Neuroendocrine Features Cancer Res., December 1, 2005; 65(23): 10680 - 10685. [Abstract] [Full Text] [PDF]