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[Cancer Research 65, 7037-7040, August 15, 2005]
© 2005 American Association for Cancer Research

Review Articles

Restarting the Cell Cycle When the Checkpoint Comes to a Halt

Marcel A.T.M. van Vugt, Alexandra Bràs and René H. Medema

Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands

Requests for reprints: René H. Medema, Laboratory of Experimental Oncology, University Medical Center Utrecht, Stratenum 2.118, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. Phone: 31-30-2539689; Fax: 31-30-2538479; E-mail: r.h.medema{at}med.uu.nl.

The DNA damage checkpoint coordinates a block in cell proliferation with the DNA repair process that follows when lesions are inflicted on the genome. However, we do not know exactly how cell division can recommence following a DNA damage–induced arrest. Recent work from our lab has identified Polo-like kinase-1 and Cdc25B as two essential components of the machinery that sets the cell division process back in motion when the checkpoint response is abrogated. Here, we discuss these novel insights and discuss their possible implications for the treatment of cancer.




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Copyright © 2005 by the American Association for Cancer Research.