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1 Comprehensive Cancer Center, Ohio State University, Columbus, Ohio; 2 Dipartimento di Medicina Sperimentale e Diagnostica, e Centro Interdipartimentale per la Ricerca sul Cancro, Università di Ferrara, Ferrara, Italy; 3 Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy; Departments of 4 Pathology, Anatomy and Cell Biology and 5 Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania; and 6 Ce.S.I. Aging Research Center, Chieti, Italy
Requests for reprints: Carlo M. Croce, Comprehensive Cancer Center, Ohio State University, Room 445C, Wiseman Hall, 400 12th Avenue, Columbus, OH 43210. Phone: 614-292-3063; Fax: 614-292-3312; E-mail: Carlo.Croce{at}osumc.edu.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.
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|
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|
|
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|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 X. Tang, J. Gal, X. Zhuang, W. Wang, H. Zhu, and G. Tang A simple array platform for microRNA analysis and its application in mouse tissues RNA, October 1, 2007; 13(10): 1803 - 1822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
B. Berkhout and K.-T. Jeang RISCy Business: MicroRNAs, Pathogenesis, and Viruses J. Biol. Chem., September 14, 2007; 282(37): 26641 - 26645. [Full Text] [PDF]
|
|
|
|
|
|
M. Kruhoffer, L. Dyrskjot, T. Voss, R. L.P. Lindberg, R. Wyrich, T. Thykjaer, and T. F. Orntoft Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube J. Mol. Diagn., September 1, 2007; 9(4): 452 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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W. Zhang, J. E. Dahlberg, and W. Tam MicroRNAs in Tumorigenesis: A Primer Am. J. Pathol., September 1, 2007; 171(3): 728 - 738. [Abstract] [Full Text] [PDF]
|
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C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al. The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells Cancer Res., August 15, 2007; 67(16): 7713 - 7722. [Abstract] [Full Text] [PDF]
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|
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|
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|
 A. Goga and C. Benz Anti-Oncomir Suppression of Tumor Phenotypes Mol. Interv., August 1, 2007; 7(4): 199 - 202. [Abstract] [Full Text] [PDF]
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 T. Thum, P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, L. W. van Laake, P. A. Doevendans, C. L. Mummery, J. Borlak, A. Haverich, et al. MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure Circulation, July 17, 2007; 116(3): 258 - 267. [Abstract] [Full Text] [PDF]
|
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C. Slape, H. Hartung, Y.-W. Lin, J. Bies, L. Wolff, and P. D. Aplan Retroviral Insertional Mutagenesis Identifies Genes that Collaborate with NUP98-HOXD13 during Leukemic Transformation Cancer Res., June 1, 2007; 67(11): 5148 - 5155. [Abstract] [Full Text] [PDF]
|
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|
 |
|
 M. Negrini, M. Ferracin, S. Sabbioni, and C. M. Croce MicroRNAs in human cancer: from research to therapy J. Cell Sci., June 1, 2007; 120(11): 1833 - 1840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhu, M.-L. Si, H. Wu, and Y.-Y. Mo MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1) J. Biol. Chem., May 11, 2007; 282(19): 14328 - 14336. [Abstract] [Full Text] [PDF]
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M. Bloomston, W. L. Frankel, F. Petrocca, S. Volinia, H. Alder, J. P. Hagan, C.-G. Liu, D. Bhatt, C. Taccioli, and C. M. Croce MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis JAMA, May 2, 2007; 297(17): 1901 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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S. A. Waldman and A. Terzic Translating MicroRNA Discovery Into Clinical Biomarkers in Cancer JAMA, May 2, 2007; 297(17): 1923 - 1925. [Full Text] [PDF]
|
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|
 |
|
 R. Duan, C. Pak, and P. Jin Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA Hum. Mol. Genet., May 1, 2007; 16(9): 1124 - 1131. [Abstract] [Full Text] [PDF]
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 |
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 B. D. Adams, H. Furneaux, and B. A. White The Micro-Ribonucleic Acid (miRNA) miR-206 Targets the Human Estrogen Receptor-{alpha} (ER{alpha}) and Represses ER{alpha} Messenger RNA and Protein Expression in Breast Cancer Cell Lines Mol. Endocrinol., May 1, 2007; 21(5): 1132 - 1147. [Abstract] [Full Text] [PDF]
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 A. R.J. Young and M. Narita Oncogenic HMGA2: short or small? Genes & Dev., May 1, 2007; 21(9): 1005 - 1009. [Full Text] [PDF]
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C. Blenkiron and E. A. Miska miRNAs in cancer: approaches, aetiology, diagnostics and therapy Hum. Mol. Genet., April 15, 2007; 16(R1): R106 - R113. [Abstract] [Full Text] [PDF]
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A. Gaur, D. A. Jewell, Y. Liang, D. Ridzon, J. H. Moore, C. Chen, V. R. Ambros, and M. A. Israel Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines Cancer Res., March 15, 2007; 67(6): 2456 - 2468. [Abstract] [Full Text] [PDF]
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