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[Cancer Research 65, 8065-8068, September 15, 2005]
© 2005 American Association for Cancer Research

Review Articles

Marrying Immunotherapy with Chemotherapy: Why Say IDO?

Alexander J. Muller and George C. Prendergast

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania

Requests for reprints: Alexander J. Muller, Lankenau Institute for Medical Research, Wynnewood, PA 19096. Phone: 610-645-8034; Fax: 610-645-2095; E-mail: mullera{at}mlhs.org.

Activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facilitates immune escape. A recent study now shows how small-molecule inhibitors of IDO can be used to leverage the efficacy of traditional chemotherapeutic drugs that are used to treat cancer in the clinic. By promoting antitumor immune responses in combination with cytotoxic chemotherapy, IDO inhibitors may offer a drug-based strategy to more effectively attack systemic cancer.




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Copyright © 2005 by the American Association for Cancer Research.