Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Translational Medicine Conference in Israel
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Colombo, M. P.
Right arrow Articles by Mantovani, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Colombo, M. P.
Right arrow Articles by Mantovani, A.
Related Collections
Right arrow Tumor Biology
Right arrow Tumor Biology: Inflammation and Immune Escape
[Cancer Research 65, 9113-9116, October 15, 2005]
© 2005 American Association for Cancer Research

Review Articles

Targeting Myelomonocytic Cells to Revert Inflammation-Dependent Cancer Promotion

Mario P. Colombo1 and Alberto Mantovani2

1 Immunotherapy and Gene Therapy Unit, Istituto Nazionale Tumori and 2 Istituto Clinico Humanitas, Rozzano and Institute of General Pathology, Medical Faculty, University of Milan, Milan, Italy

Requests for reprints: Mario P. Colombo, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy. Phone: 39-2-2390-2252; Fax: 39-2-2390-2630; E-mail: mario.colombo{at}istitutotumori.mi.it.

Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
C. Badoual, G. Bouchaud, N. E. H. Agueznay, E. Mortier, S. Hans, A. Gey, F. Fernani, S. Peyrard, P. L. -Puig, P. Bruneval, et al.
The Soluble {alpha} Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer
Cancer Res., May 15, 2008; 68(10): 3907 - 3914.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Minami, K. Shimizu, Y. Okamoto, E. Folco, M.-L. Ilasaca, M. W. Feinberg, M. Aikawa, and P. Libby
Prostaglandin E Receptor Type 4-associated Protein Interacts Directly with NF-{kappa}B1 and Attenuates Macrophage Activation
J. Biol. Chem., April 11, 2008; 283(15): 9692 - 9703.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Zhang, Y. Zhang, N. A. Bowerman, A. Schietinger, Y.-X. Fu, D. M. Kranz, D. A. Rowley, and H. Schreiber
Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma
Cancer Res., March 1, 2008; 68(5): 1563 - 1571.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Duluc, Y. Delneste, F. Tan, M.-P. Moles, L. Grimaud, J. Lenoir, L. Preisser, I. Anegon, L. Catala, N. Ifrah, et al.
Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
Blood, December 15, 2007; 110(13): 4319 - 4330.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Melani, S. Sangaletti, F. M. Barazzetta, Z. Werb, and M. P. Colombo
Amino-Biphosphonate Mediated MMP-9 Inhibition Breaks the Tumor-Bone Marrow Axis Responsible for Myeloid-Derived Suppressor Cell Expansion and Macrophage Infiltration in Tumor Stroma
Cancer Res., December 1, 2007; 67(23): 11438 - 11446.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
A. Mantovani
Linking Inflammation and Cancer: The Chemokine Connection in Mestastasis
Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 7 - 10.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2005 by the American Association for Cancer Research.