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1 Immunotherapy and Gene Therapy Unit, Istituto Nazionale Tumori and 2 Istituto Clinico Humanitas, Rozzano and Institute of General Pathology, Medical Faculty, University of Milan, Milan, Italy
Requests for reprints: Mario P. Colombo, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy. Phone: 39-2-2390-2252; Fax: 39-2-2390-2630; E-mail: mario.colombo{at}istitutotumori.mi.it.
Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.
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