| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Priority Reports |
1 Laboratory of Inflammatory-Driven Carcinogenesis, Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy; 2 Department of Biological Sciences; 3 WJB Dorn Veterans Affairs Medical Center and the School of Medicine, University of South Carolina, Columbia, South Carolina; and 4 Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland
Requests for reprints: Lorne J. Hofseth, Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina Columbia, Coker Life Sciences, Room 513C, 770 Sumter Street, Columbia, SC 29208. Phone: 803-777-6627; Fax: 803-777-8356; E-mail: hofseth{at}cop.sc.edu.
Chronic inflammation contributes to tumorigenesis. The retinoblastoma protein (pRb), in its hyperphosphorylated form, releases E2 promoter binding factor-1 (E2F1), which drives cell proliferation. Here, we show that pRb is hyperphosphorylated in both mouse and human colitis. In turn, pRb hyperphosphorylation is associated with release of E2F1 from pRb, resulting in the activation of E2F1 target molecules involved in proliferation and apoptosis. These observations provide insight into the in vivo mechanisms associated with chronic colon inflammation and increased colon cancer risk.
This article has been cited by other articles:
|
|
 |
|
  M. Bluher, N. Bashan, I. Shai, I. Harman-Boehm, T. Tarnovscki, E. Avinaoch, M. Stumvoll, A. Dietrich, N. Kloting, and A. Rudich Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2507 - 2515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability Carcinogenesis, July 1, 2009; 30(7): 1073 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Barrett and E. Sloand Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance Haematologica, April 1, 2009; 94(4): 449 - 451. [Full Text] [PDF]
|
|
|
|
|
|
Y. Jin, V. S. Kotakadi, L. Ying, A. B. Hofseth, X. Cui, P. A. Wood, A. Windust, L. E. Matesic, E. A. Pena, C. Chiuzan, et al. American ginseng suppresses inflammation and DNA damage associated with mouse colitis Carcinogenesis, December 1, 2008; 29(12): 2351 - 2359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Hussain, P. He, J. Subleski, L. J. Hofseth, G. E. Trivers, L. Mechanic, A. B. Hofseth, M. Bernard, J. Schwank, G. Nguyen, et al. Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis Cancer Res., September 1, 2008; 68(17): 7130 - 7136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. S. Kotakadi, Y. Jin, A. B. Hofseth, L. Ying, X. Cui, S. Volate, A. Chumanevich, P. A. Wood, R. L. Price, A. McNeal, et al. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis Carcinogenesis, September 1, 2008; 29(9): 1799 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ying, A. B. Hofseth, D. D. Browning, M. Nagarkatti, P. S. Nagarkatti, and L. J. Hofseth Nitric Oxide Inactivates the Retinoblastoma Pathway in Chronic Inflammation Cancer Res., October 1, 2007; 67(19): 9286 - 9293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Hofseth and M. J. Wargovich Inflammation, Cancer, and Targets of Ginseng J. Nutr., January 1, 2007; 137(1): 183S - 185S. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
