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[Cancer Research 65, 9603-9606, November 1, 2005]
© 2005 American Association for Cancer Research

Reviews

Claudin Proteins in Human Cancer: Promising New Targets for Diagnosis and Therapy

Patrice J. Morin

Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Baltimore, Maryland

Requests for reprints: Patrice J. Morin, Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Box 12, 5600 Nathan Shock Drive, Baltimore, MD 21224. Phone: 410-558-8506; Fax: 410-558-8386; E-mail: Morinp{at}grc.nia.nih.gov.

The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.




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