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[Cancer Research 65, 9628-9632, November 1, 2005]
© 2005 American Association for Cancer Research

Priority Reports

A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

Yoji Hayashita1,4, Hirotaka Osada1, Yoshio Tatematsu1, Hideki Yamada1,2, Kiyoshi Yanagisawa1,2, Shuta Tomida1,2, Yasushi Yatabe3, Katsunobu Kawahara4, Yoshitaka Sekido1 and Takashi Takahashi1,2

1 Division of Molecular Oncology, Aichi Cancer Center Research Institute; 2 Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine; 3 Departments of Anatomic and Molecular Diagnostic Pathology, Aichi Cancer Center Hospital, Nagoya, Japan; and 4 Department of Oncological Science (Surgery II), Oita University Faculty of Medicine, Oita, Japan

Requests for reprints: Takashi Takahashi, Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Phone: 81-52-744-2454; Fax: 81-52-744-2457; E-mail: tak{at}med.nagoya-u.ac.jp.

MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of 19 lung cancer cell lines. As a result, we found for the first time that the miR-17-92 cluster, which comprises seven miRNAs and resides in intron 3 of the C13orf25 gene at 13q31.3, is markedly overexpressed in lung cancers, especially with small-cell lung cancer histology. Southern blot analysis revealed the presence of increased gene copy numbers of the miRNA cluster in a fraction of lung cancer cell lines with overexpression. In addition, we were able to show predominant localization of C13orf25 transcripts within the nucleus and introduction of the expression construct of the miR-17-92 cluster, but not the putative open reading frame of C13orf25, enhancing lung cancer cell growth. These findings clearly suggest that marked overexpression of the miR-17-92 cluster with occasional gene amplification may play a role in the development of lung cancers, especially in their most aggressive form, small-cell lung cancer, and that the C13orf25 gene may well be serving as a vehicle in this regard.




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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
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[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
S M Khoshnaw, A R Green, D G Powe, and I O Ellis
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J. Clin. Pathol., May 1, 2009; 62(5): 422 - 428.
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Mol. Cancer Res., December 1, 2008; 6(12): 1830 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
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Association between High miR-211 microRNA Expression and the Poor Prognosis of Oral Carcinoma
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[Abstract] [Full Text] [PDF]

Home page
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S. Tokumaru, M. Suzuki, H. Yamada, M. Nagino, and T. Takahashi
let-7 regulates Dicer expression and constitutes a negative feedback loop
Carcinogenesis, November 1, 2008; 29(11): 2073 - 2077.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
T. Yokoyama, H. Osada, H. Murakami, Y. Tatematsu, T. Taniguchi, Y. Kondo, Y. Yatabe, Y. Hasegawa, K. Shimokata, Y. Horio, et al.
YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
Carcinogenesis, November 1, 2008; 29(11): 2139 - 2146.
[Abstract] [Full Text] [PDF]

Home page
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A. Markou, E. G. Tsaroucha, L. Kaklamanis, M. Fotinou, V. Georgoulias, and E. S. Lianidou
Prognostic Value of Mature MicroRNA-21 and MicroRNA-205 Overexpression in Non-Small Cell Lung Cancer by Quantitative Real-Time RT-PCR
Clin. Chem., October 1, 2008; 54(10): 1696 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Wu, N. Jolicoeur, Z. Li, L. Zhang, Y. Fortin, D. L'Abbe, Z. Yu, and S.-H. Shen
Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs
Carcinogenesis, September 1, 2008; 29(9): 1710 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Connolly, M. Melegari, P. Landgraf, T. Tchaikovskaya, B. C. Tennant, B. L. Slagle, L. E. Rogler, M. Zavolan, T. Tuschl, and C. E. Rogler
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Am. J. Pathol., September 1, 2008; 173(3): 856 - 864.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
Z. Yu, C. Wang, M. Wang, Z. Li, M. C. Casimiro, M. Liu, K. Wu, J. Whittle, X. Ju, T. Hyslop, et al.
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
J. Cell Biol., August 11, 2008; 182(3): 509 - 517.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Taguchi, K. Yanagisawa, M. Tanaka, K. Cao, Y. Matsuyama, H. Goto, and T. Takahashi
Identification of Hypoxia-Inducible Factor-1{alpha} as a Novel Target for miR-17-92 MicroRNA Cluster
Cancer Res., July 15, 2008; 68(14): 5540 - 5545.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. J. Kort, L. Farber, M. Tretiakova, D. Petillo, K. A. Furge, X. J. Yang, A. Cornelius, and B. T. Teh
The E2F3-Oncomir-1 Axis Is Activated in Wilms' Tumor
Cancer Res., June 1, 2008; 68(11): 4034 - 4038.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Jongen-Lavrencic, S. M. Sun, M. K. Dijkstra, P. J. M. Valk, and B. Lowenberg
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
Blood, May 15, 2008; 111(10): 5078 - 5085.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Wang, A. T. C. Lee, J. Z. I. Ma, J. Wang, J. Ren, Y. Yang, E. Tantoso, K.-B. Li, L. L. P. J Ooi, P. Tan, et al.
Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target
J. Biol. Chem., May 9, 2008; 283(19): 13205 - 13215.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J.-W. Lee, C. H. Choi, J.-J. Choi, Y.-A. Park, S.-J. Kim, S. Y. Hwang, W. Y. Kim, T.-J. Kim, J.-H. Lee, B.-G. Kim, et al.
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Clin. Cancer Res., May 1, 2008; 14(9): 2535 - 2542.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. J. Nam, H. Yoon, S. W. Kim, H. Kim, Y. T. Kim, J. H. Kim, J. W. Kim, and S. Kim
MicroRNA Expression Profiles in Serous Ovarian Carcinoma
Clin. Cancer Res., May 1, 2008; 14(9): 2690 - 2695.
[Abstract] [Full Text] [PDF]

Home page
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Y. Lu, T. Okubo, E. Rawlins, and B. L. M. Hogan
Epithelial Progenitor Cells of the Embryonic Lung and the Role of MicroRNAs in Their Proliferation
Proceedings of the ATS, April 15, 2008; 5(3): 300 - 304.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Y. Yao, Y. Zhao, H. Xu, L. P. Smith, C. H. Lawrie, M. Watson, and V. Nair
MicroRNA Profile of Marek's Disease Virus-Transformed T-Cell Line MSB-1: Predominance of Virus-Encoded MicroRNAs
J. Virol., April 15, 2008; 82(8): 4007 - 4015.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
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MicroRNA-Cancer Connection: The Beginning of a New Tale
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 667 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. Ivanovska, A. S. Ball, R. L. Diaz, J. F. Magnus, M. Kibukawa, J. M. Schelter, S. V. Kobayashi, L. Lim, J. Burchard, A. L. Jackson, et al.
MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression
Mol. Cell. Biol., April 1, 2008; 28(7): 2167 - 2174.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. Zhang
MicroRNomics: a newly emerging approach for disease biology
Physiol Genomics, April 1, 2008; 33(2): 139 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Wang, Y. C. Li, J. Wang, J. Kong, Y. Qi, R. J. Quigg, and X. Li
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130
PNAS, February 26, 2008; 105(8): 2889 - 2894.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. J. Schetter, S. Y. Leung, J. J. Sohn, K. A. Zanetti, E. D. Bowman, N. Yanaihara, S. T. Yuen, T. L. Chan, D. L. W. Kwong, G. K. H. Au, et al.
MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma
JAMA, January 30, 2008; 299(4): 425 - 436.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Scherr, L. Venturini, K. Battmer, M. Schaller-Schoenitz, D. Schaefer, I. Dallmann, A. Ganser, and M. Eder
Lentivirus-mediated antagomir expression for specific inhibition of miRNA function
Nucleic Acids Res., December 3, 2007; 35(22): e149 - e149.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. Gou, H. Zhang, P. S. Baviskar, and L. Liu
Primer extension-based method for the generation of a siRNA/miRNA expression vector
Physiol Genomics, November 14, 2007; 31(3): 554 - 562.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
X. Tang, J. Gal, X. Zhuang, W. Wang, H. Zhu, and G. Tang
A simple array platform for microRNA analysis and its application in mouse tissues
RNA, October 1, 2007; 13(10): 1803 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J.-W. Cui, Y.-J. Li, A. Sarkar, J. Brown, Y.-H. Tan, M. Premyslova, C. Michaud, N. Iscove, G.-J. Wang, and Y. Ben-David
Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation
Blood, October 1, 2007; 110(7): 2631 - 2640.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Zhang, J. E. Dahlberg, and W. Tam
MicroRNAs in Tumorigenesis: A Primer
Am. J. Pathol., September 1, 2007; 171(3): 728 - 738.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Tanaka, K. Yanagisawa, K. Shinjo, A. Taguchi, K. Maeno, S. Tomida, Y. Shimada, H. Osada, T. Kosaka, H. Matsubara, et al.
Lineage-Specific Dependency of Lung Adenocarcinomas on the Lung Development Regulator TTF-1
Cancer Res., July 1, 2007; 67(13): 6007 - 6011.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W.-O. Lui, N. Pourmand, B. K. Patterson, and A. Fire
Patterns of Known and Novel Small RNAs in Human Cervical Cancer
Cancer Res., July 1, 2007; 67(13): 6031 - 6043.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. P. Porkka, M. J. Pfeiffer, K. K. Waltering, R. L. Vessella, T. L.J. Tammela, and T. Visakorpi
MicroRNA Expression Profiling in Prostate Cancer
Cancer Res., July 1, 2007; 67(13): 6130 - 6135.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. M. Shah, K. Morimura, Q. Yang, T. Tanabe, M. Takagi, and F. J. Gonzalez
Peroxisome Proliferator-Activated Receptor {alpha} Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation
Mol. Cell. Biol., June 15, 2007; 27(12): 4238 - 4247.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Negrini, M. Ferracin, S. Sabbioni, and C. M. Croce
MicroRNAs in human cancer: from research to therapy
J. Cell Sci., June 1, 2007; 120(11): 1833 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Venturini, K. Battmer, M. Castoldi, B. Schultheis, A. Hochhaus, M. U. Muckenthaler, A. Ganser, M. Eder, and M. Scherr
Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells
Blood, May 15, 2007; 109(10): 4399 - 4405.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Blenkiron and E. A. Miska
miRNAs in cancer: approaches, aetiology, diagnostics and therapy
Hum. Mol. Genet., April 15, 2007; 16(R1): R106 - R113.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
N. Yanaihara, M. Seike, A. Schetter, C.M. Croce, and C.C. Harris
MicroRNA Molecular Profiles in Cancer Diagnosis and Prognosis
Am. Assoc. Cancer Res. Educ. Book, April 14, 2007; 2007(1): 125 - 126.
[Full Text] [PDF]

Home page
 ScienceHome page
R. Triboulet, B. Mari, Y.-L. Lin, C. Chable-Bessia, Y. Bennasser, K. Lebrigand, B. Cardinaud, T. Maurin, P. Barbry, V. Baillat, et al.
Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication
Science, March 16, 2007; 315(5818): 1579 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Gaur, D. A. Jewell, Y. Liang, D. Ridzon, J. H. Moore, C. Chen, V. R. Ambros, and M. A. Israel
Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines
Cancer Res., March 15, 2007; 67(6): 2456 - 2468.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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Direct Regulation of an Oncogenic Micro-RNA Cluster by E2F Transcription Factors
J. Biol. Chem., January 26, 2007; 282(4): 2130 - 2134.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Sylvestre, V. De Guire, E. Querido, U. K. Mukhopadhyay, V. Bourdeau, F. Major, G. Ferbeyre, and P. Chartrand
An E2F/miR-20a Autoregulatory Feedback Loop
J. Biol. Chem., January 26, 2007; 282(4): 2135 - 2143.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Williamson, J. Selfe, T. Gordon, Y.-J. Lu, K. Pritchard-Jones, K. Murai, P. Jones, P. Workman, and J. Shipley
Role for Amplification and Expression of Glypican-5 in Rhabdomyosarcoma
Cancer Res., January 1, 2007; 67(1): 57 - 65.
[Abstract] [Full Text] [PDF]

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 CarcinogenesisHome page
H. Osada and T. Takahashi
MicroRNAs in biological processes and carcinogenesis
Carcinogenesis, January 1, 2007; 28(1): 2 - 12.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
N. Sugito, H. Ishiguro, Y. Kuwabara, M. Kimura, A. Mitsui, H. Kurehara, T. Ando, R. Mori, N. Takashima, R. Ogawa, et al.
RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients
Clin. Cancer Res., December 15, 2006; 12(24): 7322 - 7328.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. L. Wang, B. B. Wang, G. Bartha, L. Li, N. Channa, M. Klinger, N. Killeen, and M. Wabl
Activation of an oncogenic microRNA cistron by provirus integration
PNAS, December 5, 2006; 103(49): 18680 - 18684.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
A. Hossain, M. T. Kuo, and G. F. Saunders
Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA
Mol. Cell. Biol., November 1, 2006; 26(21): 8191 - 8201.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
B. Ason, D. K. Darnell, B. Wittbrodt, E. Berezikov, W. P. Kloosterman, J. Wittbrodt, P. B. Antin, and R. H. A. Plasterk
From the Cover: Differences in vertebrate microRNA expression
PNAS, September 26, 2006; 103(39): 14385 - 14389.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
G. A. Calin and C. M. Croce
MicroRNA-Cancer Connection: The Beginning of a New Tale.
Cancer Res., August 1, 2006; 66(15): 7390 - 7394.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
L. Zhang, J. Huang, N. Yang, J. Greshock, M. S. Megraw, A. Giannakakis, S. Liang, T. L. Naylor, A. Barchetti, M. R. Ward, et al.
microRNAs exhibit high frequency genomic alterations in human cancer
PNAS, June 13, 2006; 103(24): 9136 - 9141.
[Abstract] [Full Text] [PDF]


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