Cancer Research Cancer Epigenetics Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Collins, A. T.
Right arrow Articles by Maitland, N. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Collins, A. T.
Right arrow Articles by Maitland, N. J.
[Cancer Research 65, 10946-10951, December 1, 2005]
© 2005 American Association for Cancer Research

Cell and Tumor Biology

Prospective Identification of Tumorigenic Prostate Cancer Stem Cells

Anne T. Collins1, Paul A. Berry1, Catherine Hyde1, Michael J. Stower2 and Norman J. Maitland1

1 Yorkshire Cancer Research Unit, Department of Biology, University of York and 2 Department of Urology, York Hospital, National Health Service Trust, York, United Kingdom

Requests for reprints: Anne T. Collins, Yorkshire Cancer Research Unit, Department of Biology, University of York, Heslington, York YO31 5D, United Kingdom. Phone: 44-1904-328708; Fax: 44-1904-328710; E-mail: ac43{at}york.ac.uk.

Existing therapies for prostate cancer eradicates the bulk of cells within a tumor. However, most patients go on to develop androgen-independent disease that remains incurable by current treatment strategies. There is now increasing evidence in some malignancies that the tumor cells are organized as a hierarchy originating from rare stem cells that are responsible for maintaining the tumor. We report here the identification and characterization of a cancer stem cell population from human prostate tumors, which possess a significant capacity for self-renewal. These cells are also able to regenerate the phenotypically mixed populations of nonclonogenic cells, which express differentiated cell products, such as androgen receptor and prostatic acid phosphatase. The cancer stem cells have a CD44+/{alpha}2ß1hi/CD133+ phenotype, and we have exploited these markers to isolate cells from a series of prostate tumors with differing Gleason grade and metastatic states. Approximately 0.1% of cells in any tumor expressed this phenotype, and there was no correlation between the number of CD44+/{alpha}2ß1hi/CD133+ cells and tumor grade. The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
D. J. Mulholland, L. Xin, A. Morim, D. Lawson, O. Witte, and H. Wu
Lin-Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten-Null Prostate Cancer Model
Cancer Res., November 15, 2009; 69(22): 8555 - 8562.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. A. Hubbard, A. M. Friel, B. Kumar, L. Zhang, B. R. Rueda, and C. E. Gargett
Evidence for Cancer Stem Cells in Human Endometrial Carcinoma
Cancer Res., November 1, 2009; 69(21): 8241 - 8248.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Bertolini, L. Roz, P. Perego, M. Tortoreto, E. Fontanella, L. Gatti, G. Pratesi, A. Fabbri, F. Andriani, S. Tinelli, et al.
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
PNAS, September 22, 2009; 106(38): 16281 - 16286.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
V. Tirino, R. Camerlingo, R. Franco, D. Malanga, A. La Rocca, G. Viglietto, G. Rocco, and G. Pirozzi
The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer
Eur. J. Cardiothorac. Surg., September 1, 2009; 36(3): 446 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. J. Hynes, K. M. Huang, and E. H. Huang
REVIEW PAPER: Implications of the "Cancer Stem Cell" Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer
Vet. Pathol., September 1, 2009; 46(5): 819 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Oda, T. Tian, M. Inoue, J.-i. Ikeda, Y. Qiu, M. Okumura, K. Aozasa, and E. Morii
Tumorigenic Role of Orphan Nuclear Receptor NR0B1 in Lung Adenocarcinoma
Am. J. Pathol., September 1, 2009; 175(3): 1235 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. J. Short and D. T. Curiel
Oncolytic adenoviruses targeted to cancer stem cells
Mol. Cancer Ther., August 1, 2009; 8(8): 2096 - 2102.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Schmidt, M. E. Scheulen, C. Dittrich, P. Obrist, N. Marschner, L. Dirix, M. Schmidt, D. Ruttinger, M. Schuler, C. Reinhardt, et al.
An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer
Ann. Onc., July 24, 2009; (2009) mdp314v1.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Rutella, G. Bonanno, A. Procoli, A. Mariotti, M. Corallo, M. G. Prisco, A. Eramo, C. Napoletano, D. Gallo, A. Perillo, et al.
Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors
Clin. Cancer Res., July 1, 2009; 15(13): 4299 - 4311.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
J. Li and J. Kim
Molecular Profiles of Finasteride Effects on Prostate Carcinogenesis
Cancer Prevention Research, June 1, 2009; 2(6): 518 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Acta Biochim Biophys SinHome page
W. Zhuang, Z. Qin, and Z. Liang
The role of autophagy in sensitizing malignant glioma cells to radiation therapy
Acta Biochim Biophys Sin, May 1, 2009; 41(5): 341 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Yanagisawa, I. Kadouchi, K. Yokomori, M. Hirose, M. Hakozaki, H. Hojo, K. Maeda, E. Kobayashi, and T. Murakami
Identification and Metastatic Potential of Tumor-Initiating Cells in Malignant Rhabdoid Tumor of the Kidney
Clin. Cancer Res., May 1, 2009; 15(9): 3014 - 3022.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
E. Vlashi, K. Kim, C. Lagadec, L. D. Donna, J. T. McDonald, M. Eghbali, J. W. Sayre, E. Stefani, W. McBride, and F. Pajonk
In Vivo Imaging, Tracking, and Targeting of Cancer Stem Cells
J Natl Cancer Inst, March 4, 2009; 101(5): 350 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
Hongling Du and H. S. Taylor
Reviews: Stem Cells and Female Reproduction
Reproductive Sciences, February 1, 2009; 16(2): 126 - 139.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
S. Ando, R. Abe, M. Sasaki, J. Murata, D. Inokuma, and H. Shimizu
Bone Marrow-Derived Cells Are Not the Origin of the Cancer Stem Cells in Ultraviolet-Induced Skin Cancer
Am. J. Pathol., February 1, 2009; 174(2): 595 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Genomics ProteomicsHome page
I. L. BOTCHKINA, R. A. ROWEHL, D. E. RIVADENEIRA, M. S. KARPEH JR., H. CRAWFORD, A. DUFOUR, J. JU, Y. WANG, Y. LEYFMAN, and G. I. BOTCHKINA
Phenotypic Subpopulations of Metastatic Colon Cancer Stem Cells: Genomic Analysis
Cancer Genomics Proteomics, January 1, 2009; 6(1): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
L. Miele, N. Takebe, and S. P. Ivy
The Cancer Stem Cell Hypothesis, Embryonic Signaling Pathways, and Therapeutics: Targeting an Elusive Concept
ASCO Educational Book, January 1, 2009; 2009(1): 145 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. S. Goldstein, D. A. Lawson, D. Cheng, W. Sun, I. P. Garraway, and O. N. Witte
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics
PNAS, December 30, 2008; 105(52): 20882 - 20887.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Wang, Y. Lu, J. Wang, A. E. Koch, J. Zhang, and R. S. Taichman
CXCR6 Induces Prostate Cancer Progression by the AKT/Mammalian Target of Rapamycin Signaling Pathway
Cancer Res., December 15, 2008; 68(24): 10367 - 10377.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. J. Vander Griend, W. L. Karthaus, S. Dalrymple, A. Meeker, A. M. DeMarzo, and J. T. Isaacs
The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells
Cancer Res., December 1, 2008; 68(23): 9703 - 9711.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
R.U. Lukacs, D.A. Lawson, L. Xin, Y. Zong, I. Garraway, A.S. Goldstein, S. Memarzadeh, and O.N. Witte
Epithelial Stem Cells of the Prostate and Their Role in Cancer Progression
Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.73.012v1.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Zucchi, S. Astigiano, G. Bertalot, S. Sanzone, C. Cocola, P. Pelucchi, G. Bertoli, M. Stehling, O. Barbieri, A. Albertini, et al.
Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells
PNAS, November 4, 2008; 105(44): 16940 - 16945.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Du, H. Wang, L. He, J. Zhang, B. Ni, X. Wang, H. Jin, N. Cahuzac, M. Mehrpour, Y. Lu, et al.
CD44 is of Functional Importance for Colorectal Cancer Stem Cells
Clin. Cancer Res., November 1, 2008; 14(21): 6751 - 6760.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. C. Kirkland and H. Ying
{alpha}2{beta}1 Integrin Regulates Lineage Commitment in Multipotent Human Colorectal Cancer Cells
J. Biol. Chem., October 10, 2008; 283(41): 27612 - 27619.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. M. Yi, H.-C. Tsai, S. C. Glockner, S. Lin, J. E. Ohm, H. Easwaran, C. D. James, J. F. Costello, G. Riggins, C. G. Eberhart, et al.
Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors
Cancer Res., October 1, 2008; 68(19): 8094 - 8103.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
B. Bussolati, S. Bruno, C. Grange, U. Ferrando, and G. Camussi
Identification of a tumor-initiating stem cell population in human renal carcinomas
FASEB J, October 1, 2008; 22(10): 3696 - 3705.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. M. Simeone
Pancreatic Cancer Stem Cells: Implications for the Treatment of Pancreatic Cancer
Clin. Cancer Res., September 15, 2008; 14(18): 5646 - 5648.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
H. L. Goel, J. Li, S. Kogan, and L. R Languino
Integrins in prostate cancer progression
Endocr. Relat. Cancer, September 1, 2008; 15(3): 657 - 664.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. P. Risbridger and R. A. Taylor
Regulation of Prostatic Stem Cells by Stromal Niche in Health and Disease
Endocrinology, September 1, 2008; 149(9): 4303 - 4306.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W.-W. Chang, C. H. Lee, P. Lee, J. Lin, C.-W. Hsu, J.-T. Hung, J.-J. Lin, J.-C. Yu, L.-e. Shao, J. Yu, et al.
Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis
PNAS, August 19, 2008; 105(33): 11667 - 11672.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J.-i. Ikeda, E. Morii, Y. Liu, Y. Qiu, N. Nakamichi, R. Jokoji, Y. Miyoshi, S. Noguchi, and K. Aozasa
Prognostic Significance of CD55 Expression in Breast Cancer
Clin. Cancer Res., August 1, 2008; 14(15): 4780 - 4786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Xiao, Y. Ye, K. Yearsley, S. Jones, and S. H. Barsky
The Lymphovascular Embolus of Inflammatory Breast Cancer Expresses a Stem Cell-Like Phenotype
Am. J. Pathol., August 1, 2008; 173(2): 561 - 574.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
N. J. Maitland and A. T. Collins
Prostate Cancer Stem Cells: A New Target for Therapy
J. Clin. Oncol., June 10, 2008; 26(17): 2862 - 2870.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. E.P. Prince and L. E. Ailles
Cancer Stem Cells in Head and Neck Squamous Cell Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2871 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Takaishi, T. Okumura, and T. C. Wang
Gastric Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2876 - 2882.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. D. Peacock and D. N. Watkins
Cancer Stem Cells and the Ontogeny of Lung Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2883 - 2889.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. S. Hart and W. S. El-Deiry
Invincible, but Not Invisible: Imaging Approaches Toward In Vivo Detection of Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2901 - 2910.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Zhang, C. Balch, M. W. Chan, H.-C. Lai, D. Matei, J. M. Schilder, P. S. Yan, T. H-M. Huang, and K. P. Nephew
Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
Cancer Res., June 1, 2008; 68(11): 4311 - 4320.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
L Ricci-Vitiani, A Pagliuca, E Palio, A Zeuner, and R De Maria
Colon cancer stem cells
Gut, April 1, 2008; 57(4): 538 - 548.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Engelmann, H. Shen, and O. J. Finn
MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1
Cancer Res., April 1, 2008; 68(7): 2419 - 2426.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. Mimeault, P. P. Mehta, R. Hauke, and S. K. Batra
Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies
Endocr. Rev., April 1, 2008; 29(2): 234 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. M. Bera, D. N. R. Veeramachaneni, and K. Pandher
Characterization of a Biphasic Neoplasm in a Madagascar Tree Boa (Sanzinia madagascariensis)
Vet. Pathol., March 1, 2008; 45(2): 259 - 263.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Wang, Y. Shiozawa, J. Wang, Y. Wang, Y. Jung, K. J. Pienta, R. Mehra, R. Loberg, and R. S. Taichman
The Role of CXCR7/RDC1 as a Chemokine Receptor for CXCL12/SDF-1 in Prostate Cancer
J. Biol. Chem., February 15, 2008; 283(7): 4283 - 4294.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Liu, C. Ginestier, E. Charafe-Jauffret, H. Foco, C. G. Kleer, S. D. Merajver, G. Dontu, and M. S. Wicha
BRCA1 regulates human mammary stem/progenitor cell fate
PNAS, February 5, 2008; 105(5): 1680 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
P. B Dirks
Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells
Phil Trans R Soc B, January 12, 2008; 363(1489): 139 - 152.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Zeppernick, R. Ahmadi, B. Campos, C. Dictus, B. M. Helmke, N. Becker, P. Lichter, A. Unterberg, B. Radlwimmer, and C. C. Herold-Mende
Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients
Clin. Cancer Res., January 1, 2008; 14(1): 123 - 129.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. Tang, B. T. Ang, and S. Pervaiz
Cancer stem cell: target for anti-cancer therapy
FASEB J, December 1, 2007; 21(14): 3777 - 3785.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
T. Reiner, A. de las Pozas, R. Parrondo, and C. Perez-Stable
Progression of Prostate Cancer from a Subset of p63-Positive Basal Epithelial Cells in FG/Tag Transgenic Mice
Mol. Cancer Res., November 1, 2007; 5(11): 1171 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. E. Kern and D. Shibata
The Fuzzy Math of Solid Tumor Stem Cells: A Perspective
Cancer Res., October 1, 2007; 67(19): 8985 - 8988.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Mimeault and S. K. Batra
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies
Ann. Onc., October 1, 2007; 18(10): 1605 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
H. Jiang, C. Gomez-Manzano, H. Aoki, M. M. Alonso, S. Kondo, F. McCormick, J. Xu, Y. Kondo, B. N. Bekele, H. Colman, et al.
Examination of the Therapeutic Potential of Delta-24-RGD in Brain Tumor Stem Cells: Role of Autophagic Cell Death
J Natl Cancer Inst, September 19, 2007; 99(18): 1410 - 1414.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. T. Buijs, C. A. Rentsch, G. van der Horst, P. G.M. van Overveld, A. Wetterwald, R. Schwaninger, N. V. Henriquez, P. ten Dijke, F. Borovecki, R. Markwalder, et al.
BMP7, a Putative Regulator of Epithelial Homeostasis in the Human Prostate, Is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo
Am. J. Pathol., September 1, 2007; 171(3): 1047 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Patrawala, T. Calhoun-Davis, R. Schneider-Broussard, and D. G. Tang
Hierarchical Organization of Prostate Cancer Cells in Xenograft Tumors: The CD44+{alpha}2{beta}1+ Cell Population Is Enriched in Tumor-Initiating Cells
Cancer Res., July 15, 2007; 67(14): 6796 - 6805.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Yu, X. Sun, Y. Qiu, J. Zhou, Y. Wu, L. Zhuang, J. Chen, and Y. Ding
Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma
Clin. Cancer Res., July 1, 2007; 13(13): 3814 - 3824.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. V. Pfenninger, T. Roschupkina, F. Hertwig, D. Kottwitz, E. Englund, J. Bengzon, S. E. Jacobsen, and U. A. Nuber
CD133 Is Not Present on Neurogenic Astrocytes in the Adult Subventricular Zone, but on Embryonic Neural Stem Cells, Ependymal Cells, and Glioblastoma Cells
Cancer Res., June 15, 2007; 67(12): 5727 - 5736.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Gu, J. Yuan, M. Wills, and S. Kasper
Prostate Cancer Cells with Stem Cell Characteristics Reconstitute the Original Human Tumor In vivo
Cancer Res., May 15, 2007; 67(10): 4807 - 4815.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
G. Farnie, R. B. Clarke, K. Spence, N. Pinnock, K. Brennan, N. G. Anderson, and N. J. Bundred
Novel Cell Culture Technique for Primary Ductal Carcinoma In Situ: Role of Notch and Epidermal Growth Factor Receptor Signaling Pathways
J Natl Cancer Inst, April 18, 2007; 99(8): 616 - 627.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Wang, L.-P. Guo, L.-Z. Chen, Y.-X. Zeng, and S. H. Lu
Identification of Cancer Stem Cell-Like Side Population Cells in Human Nasopharyngeal Carcinoma Cell Line
Cancer Res., April 15, 2007; 67(8): 3716 - 3724.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Miki, B. Furusato, H. Li, Y. Gu, H. Takahashi, S. Egawa, I. A. Sesterhenn, D. G. McLeod, S. Srivastava, and J. S. Rhim
Identification of Putative Stem Cell Markers, CD133 and CXCR4, in hTERT-Immortalized Primary Nonmalignant and Malignant Tumor-Derived Human Prostate Epithelial Cell Lines and in Prostate Cancer Specimens
Cancer Res., April 1, 2007; 67(7): 3153 - 3161.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. M. Flynn and D. S. Kaufman
Donor cell leukemia: insight into cancer stem cells and the stem cell niche
Blood, April 1, 2007; 109(7): 2688 - 2692.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Mimeault, S. L. Johansson, G. Vankatraman, E. Moore, J.-P. Henichart, P. Depreux, M.-F. Lin, and S. K. Batra
Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells
Mol. Cancer Ther., March 1, 2007; 6(3): 967 - 978.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
T. M. Phillips, W. H. McBride, and F. Pajonk
The Response of CD24-/low/CD44+ Breast Cancer-Initiating Cells to Radiation
J Natl Cancer Inst, December 20, 2006; 98(24): 1777 - 1785.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Bruno, B. Bussolati, C. Grange, F. Collino, M. E. Graziano, U. Ferrando, and G. Camussi
CD133+ Renal Progenitor Cells Contribute to Tumor Angiogenesis
Am. J. Pathol., December 1, 2006; 169(6): 2223 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Perk, I. Gil-Bazo, Y. Chin, P. de Candia, J. J.S. Chen, Y. Zhao, S. Chao, W. Cheong, Y. Ke, H. Al-Ahmadie, et al.
Reassessment of Id1 Protein Expression in Human Mammary, Prostate, and Bladder Cancers Using a Monospecific Rabbit Monoclonal Anti-Id1 Antibody.
Cancer Res., November 15, 2006; 66(22): 10870 - 10877.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. O. Sakariassen, L. Prestegarden, J. Wang, K.-O. Skaftnesmo, R. Mahesparan, C. Molthoff, P. Sminia, E. Sundlisaeter, A. Misra, B. B. Tysnes, et al.
Angiogenesis-independent tumor growth mediated by stem-like cancer cells
PNAS, October 31, 2006; 103(44): 16466 - 16471.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. V. Litvinov, D. J. Vander Griend, Y. Xu, L. Antony, S. L. Dalrymple, and J. T. Isaacs
Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells.
Cancer Res., September 1, 2006; 66(17): 8598 - 8607.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. L. Hall, J. Dai, K. L. van Golen, E. T. Keller, and M. W. Long
Type I Collagen Receptor ({alpha}2{beta}1) Signaling Promotes the Growth of Human Prostate Cancer Cells within the Bone.
Cancer Res., September 1, 2006; 66(17): 8648 - 8654.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Mehra, M. Penning, J. Maas, L. V. Beerepoot, N. van Daal, C. H. van Gils, R. H. Giles, and E. E. Voest
Progenitor Marker CD133 mRNA Is Elevated in Peripheral Blood of Cancer Patients with Bone Metastases.
Clin. Cancer Res., August 15, 2006; 12(16): 4859 - 4866.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. F. Hezel, A. C. Kimmelman, B. Z. Stanger, N. Bardeesy, and R. A. DePinho
Genetics and biology of pancreatic ductal adenocarcinoma.
Genes & Dev., May 15, 2006; 20(10): 1218 - 1249.
[Abstract] [Full Text] [PDF]

Home page
 IBMS BoneKEyHome page
G. J. Strewler
The Stem Cell Niche and Bone Metastasis
IBMS BoneKEy, May 1, 2006; 3(5): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. J. Pienta and D. Bradley
Mechanisms underlying the development of androgen-independent prostate cancer.
Clin. Cancer Res., March 15, 2006; 12(6): 1665 - 1671.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2005 by the American Association for Cancer Research.