Cancer Research SABCS  Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cha, T.-L.
Right arrow Articles by Hung, M.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cha, T.-L.
Right arrow Articles by Hung, M.-C.
[Cancer Research 65, 2287-2295, March 15, 2005]
© 2005 American Association for Cancer Research


Cell and Tumor Biology

Emodin Down-Regulates Androgen Receptor and Inhibits Prostate Cancer Cell Growth

Tai-Lung Cha1,2,3, Lin Qiu1, Chun-Te Chen1, Yong Wen1 and Mien-Chie Hung1,2

1 Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center and 2 Graduate School of Biomedical Science, The University of Texas Health Science Center at Houston, Houston, Texas and 3 Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Requests for reprints: Mien-Chie Hung, Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston TX 77030. Phone: 713-792-3668; Fax: 713-794-0209; E-mail: mhung{at}mdanderson.org.

Hormone-refractory relapse is an inevitable and lethal event for advanced prostate cancer patients after hormone deprivation. A growing body of evidence indicates that hormone deprivation may promote this aggressive prostate cancer phenotype. Notably, androgen receptor (AR) not only mediates the effect of androgen on the tumor initiation but also plays the major role in the relapse transition. This provides a strong rationale for searching new effective agents targeting the down-regulation of AR to treat or prevent advanced prostate cancer progression. Here, we show that emodin, a natural compound, can directly target AR to suppress prostate cancer cell growth in vitro and prolong the survival of C3(1)/SV40 transgenic mice in vivo. Emodin treatment resulted in repressing androgen-dependent transactivation of AR by inhibiting AR nuclear translocation. Emodin decreased the association of AR and heat shock protein 90 and increased the association of AR and MDM2, which in turn induces AR degradation through proteasome-mediated pathway in a ligand-independent manner. Our work indicates a new mechanism for the emodin-mediated anticancer effect and justifies further investigation of emodin as a therapeutic and preventive agent for prostate cancer.

Key Words: emodin • androgen receptor • proteasome degradation • prostate cancer




This article has been cited by other articles:


Home page
J. Pharmacol. Exp. Ther.Home page
T.-C. Kuo, J.-S. Yang, M.-W. Lin, S.-C. Hsu, J.-J. Lin, H.-J. Lin, T.-C. Hsia, C.-L. Liao, M.-D. Yang, M.-J. Fan, et al.
Emodin Has Cytotoxic and Protective Effects in Rat C6 Glioma Cells: Roles of Mdr1a and Nuclear Factor {kappa}B in Cell Survival
J. Pharmacol. Exp. Ther., September 1, 2009; 330(3): 736 - 744.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
C.-H. Tsai, F.-M. Lin, Y.-C. Yang, M.-T. Lee, T.-L. Cha, G.-J. Wu, S.-C. Hsieh, and P.-W. Hsiao
Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice
Clin. Cancer Res., September 1, 2009; 15(17): 5435 - 5444.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
Y. Morishima, A. M. Wang, Z. Yu, W. B. Pratt, Y. Osawa, and A. P. Lieberman
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins
Hum. Mol. Genet., December 15, 2008; 17(24): 3942 - 3952.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
G. Wu, X.-L. Qiu, L. Zhou, J. Zhu, R. Chamberlin, J. Lau, P.-L. Chen, and W.-H. Lee
Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in Animal
Cancer Res., October 15, 2008; 68(20): 8393 - 8399.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
T. Vasaitis, A. Belosay, A. Schayowitz, A. Khandelwal, P. Chopra, L. K. Gediya, Z. Guo, H.-B. Fang, V. C.O. Njar, and A. M.H. Brodie
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3{beta}-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
Mol. Cancer Ther., August 1, 2008; 7(8): 2348 - 2357.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
A. Kitano, S. Saika, O. Yamanaka, K. Ikeda, Y. Okada, K. Shirai, and P. S. Reinach
Emodin Suppression of Ocular Surface Inflammatory Reaction
Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 5013 - 5022.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Zoubeidi, A. Zardan, E. Beraldi, L. Fazli, R. Sowery, P. Rennie, C. Nelson, and M. Gleave
Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity
Cancer Res., November 1, 2007; 67(21): 10455 - 10465.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
C.-T. Wu, W.-C. Chen, S.-K. Liao, C.-L. Hsu, K.-D. Lee, and M.-F. Chen
The radiation response of hormone-resistant prostate cancer induced by long-term hormone therapy
Endocr. Relat. Cancer, September 1, 2007; 14(3): 633 - 643.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2005 by the American Association for Cancer Research.